Baseline characteristics of participants.

<p>* Means (± SE) are adjusted for age,</p><p>† Means (± SE) are adjusted for age, sex, BMI ‡ p<0.05 comparing South Asians to Europeans overall,</p><p>§ p<0.05 comparing South Asian women to European women,</p><p>|| p<0.05 comparing South Asian men to European men; Physical activity score derived from the SHARE activity index (14).</p

Additional file 1: Table S1. of A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - the Diet and Genetic Intervention (DIGEST) Pilot study

Representative menu plans for the Western and prudent diets. (DOCX 62 kb

Adipose and lean tissue characteristics of participants.

<p>* Means (± SE) are adjusted for age and BMI,</p><p>† Means (± SE) are adjusted for age, sex and BMI,</p><p>|| Total fat area refers to: superficial + deep+visceral fat by MRI,</p><p>‡ p<0.05 comparing South Asians to Europeans overall,</p><p>§ p<0.05 comparing South Asian women to European women,</p><p>¶ p<0.05 comparing South Asian men to European men,</p><p>Note: There was no change in the IMCL change after adjustment for peak exercise capacity i.e. Vo2 max at 15 mins.</p

Additional file 3: Table S2. of A randomized controlled trial of the effects of a prudent diet on cardiovascular risk factors, gene expression, and DNA methylation - the Diet and Genetic Intervention (DIGEST) Pilot study

Sample size calculations for a cross-over trial [25, 26]. (DOCX 113 kb

HDL: High Density Lipoprotein, CRP: C-reactive protein.

<p>HDL: High Density Lipoprotein, CRP: C-reactive protein.</p

BMI: Body Mass Index, error bars represent the standard error.

<p>BMI: Body Mass Index, error bars represent the standard error.</p

Additional file 1: of Opioid substitution and antagonist therapy trials exclude the common addiction patient: a systematic review and analysis of eligibility criteria

Table outlining description of studies included in the systematic review. (PDF 262 kb

Socio-ecological framework adapted for SCORE! program development activities Study activities.

Socio-ecological framework adapted for SCORE! program development activities Study activities.</p

Map of Riverdale neighbourhood of Hamilton, ON, Canada.

OpenStreetMap Foundation. OpenStreetMap; 2023 [cited 2023 Jul 24]. Database: OpenStreetMap [Internet]. Available from: https://www.openstreetmap.org/copyright.</p

Key partners by sector.

BackgroundThe burden of childhood obesity and cardiometabolic risk factors affecting newcomer Canadians living in lower socioeconomic circumstances is a concerning public health issue. This paper describes Strengthening Community Roots: Anchoring Newcomers in Wellness and Sustainability (SCORE!), an academic-community research partnership to co-design interventions that nurture and optimize healthy activity living (HAL) among a community of children and families new to Canada in Hamilton, Ontario, Canada.Methods/DesignOur overarching program is informed by a socio-ecological model, and will co-create HAL interventions for children and families new to Canada rooted in outdoor, nature-based physical activity. We will proceed in three phases: Phase 1) synthesis of existing evidence regarding nature based HAL interventions among children and families; Phase 2) program development through four data collection activities including: i) community engagement activities to build trustful relationships and understand barriers and facilitators, including establishing a community advisory and action board, qualitative studies including a photovoice study, and co-design workshops to develop programs; ii) characterizing the demographics of the community through a household survey; iii) characterizing the built environment and HAL programs/services available in the community by developing an accessible real-time systems map; and iv) reviewing municipal policies relevant to HAL and sustainability; leading to Phase 3) implementation and evaluation of the feasibility of co-designed HAL programs.ConclusionThe etiology of childhood obesity and related chronic diseases is complex and multifactorial, as are intervention strategies. The SCORE! program of research brings together partners including community members, service providers, academic researchers, and organizational leaders to build a multi-component intervention that promotes the health and wellness of newcomer children and families.</div