Kindergarten children’s genetic vulnerabilities interact with friends’ aggression to promote children’s own aggression

OBJECTIVE: To examine whether kindergarten children's genetic liability to physically aggress moderates the contribution of friends' aggression to their aggressive behaviors. METHOD: Teacher and peer reports of aggression were available for 359 6-year-old twin pairs (145 MZ, 212 DZ) as well as teacher and peer reports of aggression of the two best friends of each twin. Children's genetic risk for aggression was based on their cotwin's aggression status and the pair's zygosity. RESULTS: Children's aggression was highly heritable. Unique environment accounted for most of the variance in friends' aggression, although there was also a small genetic contribution (15%). Both genetic liability to aggression and having aggressive friends predicted twins' aggression. However, the contribution of aggressive friends to children's aggression was strongest among genetically vulnerable children. This result was similar for boys and girls, despite sex differences in both aggression and the level of aggression of friends. CONCLUSIONS: Affiliation with aggressive friends at school entry is a significant environmental risk factor for aggression, especially for children genetically at risk for aggressive behaviors. Developmental models of aggression need to take into account both genetic liability and environmental factors in multiple settings, such as the peer context, to more precisely describe and understand the various developmental pathways to aggression. The implications for early prevention programs are discussed. Copyright 2007 © American Academy of Child and Adolescent Psychiatry

Understanding development and prevention of chronic physical aggression: towards experimental epigenetic studies

The aim of this paper was to highlight how developmental psychopathology, epigenetics and prevention experiments are starting to blend together to explain the developmental causes of chronic physical aggression (CPA) and, more importantly, to help prevent CPA and its associated physical, mental and social problems. After defining the keywords (prevention, chronic and physical aggression), a selected review of published studies is used to answer the following four questions: when should we attempt to prevent onset of CPA? What are the risk factors for CPA? Have early childhood interventions been shown to prevent CPA? Can early preventive interventions benefit from epigenetic studies? The last section of this paper gives two examples of experimental prevention designs that integrate present knowledge of CPA development, risk factors, early childhood preventive interventions and epigenetic programming of brain development during pregnancy and early childhood. I conclude that randomized control trials of preventive interventions during pregnancy and early childhood with a specific focus on epigenetic effects are the research design most likely to advance our understanding of the biopsychosocial mechanisms that lead to CPA, and the only research design that can identify effective interventions for preventing the development of CPA

Improving the Quality of Palliative Care through National and Regional Collaboration Efforts

BackgroundThe measurement and reporting of the quality of care in the field of palliation has become a required task for many health care leaders and specialists in palliative care. Such efforts are aided when organizations collaborate together to share lessons learned.MethodsThe authors reviewed examples of quality-improvement collaborations in palliative care to understand the similarities, differences, and future directions of quality measurement and improvement strategies in the discipline.ResultsThree examples were identified that showed areas of robust and growing quality-improvement collaboration in the field of palliative care: the Global Palliative Care Quality Alliance, Palliative Care Quality Network, and Project Educate, Nurture, Advise, Before Life Ends. These efforts exemplify how shared-improvement activities can inform improved practice for organizations participating in collaboration.ConclusionsNational and regional collaboratives can be used to enhance the quality of palliative care and are important efforts to standardize and improve the delivery of palliative care for persons with serious illness, along with their friends, family, and caregivers

PREDICTORS OF ELECTORAL TURNOUT: AN INTERNATIONAL COMPARISON *

Voter turnout in the United States is much lower than in almost all other democratic countries. This has been interpreted as a symptom of popular alienation from the political system, suspicion of politicians, and pessimism about the consequences of political activity. When these perspectives are measured directly, however, it is clear that Americans score very low on almost every item. Indeed, there is no relationship between political con- tentment and turnout. Turnout does not reflect international variations in acceptance of politicians or the political system. Rather, it responds to variations in the bureaucratic steps required to cast a ballot. The United States is one of a handful of countries that require a separate step-registra- tion-before the citizen can vote; and with the partial exception of France it is the only country in which the individual rather than the state bears the responsibility for registration. Copyright 1990 by The Policy Studies Organization.