Spearman rank order correlations between βTG and PAI-1_ag in the respective plasma preparations of the follow-up study.

<p>Spearman rank order correlations between βTG and PAI-1_ag in the respective plasma preparations of the follow-up study.</p

Comparison of βTG, PAI-1 assays and CLT according to centrifugation speed in SABPA study.

<p>Comparison of βTG, PAI-1 assays and CLT according to centrifugation speed in SABPA study.</p

PAI-1_act, PAI-1_ag, tPA/PAI-1 complex and CLT according to βTG quartiles in SABPA study group.

<p>PAI-1_act, PAI-1_ag, tPA/PAI-1 complex and CLT according to βTG quartiles in SABPA study group.</p

Spearman rank order correlations between βTG, PAI-1 assays and CLT in SABPA study group.

<p>Spearman rank order correlations between βTG, PAI-1 assays and CLT in SABPA study group.</p

Spearman rank order correlations of βTG and PAI-1_ag with whole blood, CTAD and citrate plasma platelet count of the follow-up study.

<p>Spearman rank order correlations of βTG and PAI-1_ag with whole blood, CTAD and citrate plasma platelet count of the follow-up study.</p

Design of follow-up study.

<p>Design of follow-up study.</p

Descriptive statistics of the follow-up study group.

<p>Descriptive statistics of the follow-up study group.</p

Characteristics of the South African PURE study population.

<p>Parametric data reported as mean ± SD and non-parametric data as median (25^th-75^th percentile); SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index, HDL, high density lipoprotein; LDL, low-density lipoprotein, PAI-1, plasminogen activator inhibitor type-1; HbA1c, glycosylated haemoglobin; CLT, clot-lysis time; R rural; U, urban; *Means differed significantly between sexes; rural vs. urban p-value adjusted for age and sex, and only for age where values are reported for men and women separately.</p

Non-biochemical cardiovascular disease risk factors and their association with CLT.

*<p>Moderate drinking: >0<15 g/day for women; >0<30 g/day for men; **Heavy drinking: ≥15 g/day for women; ≥30 g/day for men; ^†‡§‖Means with the same symbol differed significantly; ^¶Mean differed significantly from other means in subgroup. WC: waist circumference; BMI: Body mass index; PAI-1: Plasminogen activator inhibitor type-1. For groups with more than two subgroups the difference between the highest and lowest value are reported. N varies among variables due to lack of sample availability that occurred randomly during sample collection. ^•Model 1: adjusted for age; ^ΔModel 2: adjusted for age as well as variables indicated in table.</p

An overview of non-covalently fibrin clot-bound plasma proteins.

<p>Plasma clots were made by adding CaCl₂, thrombin and aprotinin to platelet-poor citrated normal plasma, unbound proteins were washed away and bound proteins were extracted. These proteins were separated with 2D gel electrophoresis and visualized by Sypro Ruby. A) The numbers and arrows indicate the protein spots that were excised from gel and analyzed with mass spectrometry. B) The trains of spots that resemble the same protein are indicated by white ellipses. They include: fibronectin (I), α₂-macroglobulin (II, III and VIII), plasminogen (IV), FXIII A chain (V), albumin (VI), α₁-antitrypsin (VII), apolipoprotein J (IX), apolipoprotein E, HFREP-1 (X) and apolipoprotein A-I (XI). C) A zoomed image of the 2D gel with a lower fluorescent signal. The isoforms of α₁-antitrypsin (A), apolipoprotein J (B) and apolipoprotein A-I (C) are indicated by white ellipses.</p