Force, stress and stiffness of in-vivo indentation test (mean ± SD).

Controls were measured in the contralateral tibia of the same animal.</p

Fig 3 -

Load displacement curves of indentation test (A) and three-point bending test. Different lines represent individual samples. Figures only represent a limited number of samples.</p

Stress and stiffness (mean ± SD) in ex-vivo three-point bending test.

Stress and stiffness (mean ± SD) in ex-vivo three-point bending test.</p

Mechanical testing.

A. Three-point bending test. B. Indentation test. C. Proximal tibia after indentation test.</p

Stress and stiffness (mean ± SD) in ex-vivo indentation test.

Stress and stiffness (mean ± SD) in ex-vivo indentation test.</p

S1 Dataset -

BackgroundBone metastases are on the rise due to longer survival of cancer patients. Local tumor control is required for pain relief. Microwave ablation (MWA) is a technique for minimally invasive local tumor treatment. Tumor tissue is destroyed by application of local hyperthermia to induce necrosis. Given the most common setting of palliative care, it is generally considered beneficial for patients to start mobilizing directly following treatment. No data on mechanical strength in long bones after MWA have been published so far.Materials and methodsIn- and ex-vivo experiments on sheep tibias were performed with MWA in various combinations of settings for time and power. During the in-vivo part sheep were sacrificed one or six weeks after ablation. Mechanical strength was examined with a three-point bending test for ablations in the diaphysis and with an indentation test for ablations in the metaphysis.ResultsMWA does not decrease mechanical strength in the diaphysis. In the metaphysis strength decreased up to 50% six weeks after ablation, which was not seen directly after ablation.ConclusionMWA appears to decrease mechanical strength in long bone metaphysis up to 50% after six weeks, however strength remains sufficient for direct mobilization. The time before normal strength is regained after the remodeling phase is not known.</div

In-vivo procedure.

A. Ablation probe (black) and temperature probe inserted in the bone through a positioning device. B. Intubated sheep before procedure. C. the MWA generator.</p

The prostheses.

<p>A. The novel cervical artificial disc prosthesis based on the physiological curvature of the endplate. B. Prestige LP prosthesis. C. Pressure measuring sensors on the inferior surface of the two prostheses.</p

The prostheses.

<p>A. The novel cervical artificial disc prosthesis based on the physiological curvature of the endplate. B. Prestige LP prosthesis. C. Pressure measuring sensors on the inferior surface of the two prostheses.</p

Radiographs of two different specimens.

<p>The correct position of the novel prosthesis (A) and the Prestige LP prosthesis (B).</p