Synthesis and interaction of thiazolo [2, 3-a] isoquinoline analog with DNA

569-573A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using N,N-Dicyclohexylcarbodiimide at 0−5 °C has given 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA has been studied using UV-visible spectroscopy, fluorescence and circular dichroism techniques. Static quenching mechanism is observed from fluorescence measurements of interaction between FUIQTGA and DNA. Circular dichroism reveals the minor groove binding mode between FUIQTGA and DNA

Synthesis of substituted benzo[e][1,3]oxazino analogs

325-327A synthesis of substituted benzo[e][1,3]oxazin-4-one analogs has been carried out by two methods. One of the common procedures involves refluxing in situ generated imine with salicylic acid while other method involves one-pot three component condensation reaction between aldehyde, amine and salicylic acid using DCC. The synthesized compounds have been characterized by IR, 1H and 13C NMR spectroscopy. Melting points reported are uncorrected

Synthesis and interaction of thiazolo [2, 3-a] isoquinoline analog with DNA

A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using DCC at 00-50C will give 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA was studied using UV Visible spectroscopy, fluorescence and Circular Dichroism (CD) techniques. Static quenching mechanism was observed from fluorescence measurements of interaction between FUIQTGA and DNA.  Circular Dichroism reveals the minor groove binding mode between FUIQTGA and DNA

Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server

Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range

Synthesis and Spectroscopic Investigation of Binding of Novel Thiazolo [2, 3-a] isoquinoline analog with Bovine Serum Albumin

A condensation reaction between 1-cyclobutyl-3,4-dihydroisoquinoline and thioglycolic acid was carried out using DCC yields 10b-cyclobutyl-5,6-dihydro-2H-thiazolo [2, 3-a] isoquinolin-3(10bH)-one [CBIQTGA]. The interaction of CBIQTGA with Bovine Serum Albumin (BSA) was studied using UV spectroscopy, spectrofluorimetry and circular dichroism (CD) techniques

Synthesis and spectroscopic investigation of binding of novel Thiazolo [2, 3-a] isoquinoline analog with bovine serum albumin

1081-1085A condensation reaction between 1-cyclobutyl-3,4-dihydroisoquinoline and thioglycolic acid has been carried out using DCC yields 10b-cyclobutyl-5,6-dihydro-2H-thiazolo [2, 3-a] isoquinolin-3(10bH)-one [CBIQTGA]. The synthesized compound is characterised by using spectroscopic techniques. The interaction of CBIQTGA with bovine serum albumin has been studied using UV spectroscopy, spectrofluorimetry and circular dichroism techniques

Synthesis of substituted benzo[e][1,3]oxazino analogs

A synthesis of substituted benzo[e][1,3]oxazin-4-one analogs has been carried out by two methods. One of the common procedures involves refluxing in situ generated imine with salicylic acid while other method involves one-pot three component condensation reaction between aldehyde, amine and salicylic acid using DCC. The synthesized compounds have been characterized by IR, 1H and 13C NMR spectroscopy. Melting points reported are uncorrected