Sensorineural hearing loss after suffering bacterial meningitis in children

This study is dedicated to identifying the complicationsof sensorineural hearing loss (SHL) afterbacterial meningitis (BM) in children to optimizediagnosis and timely treatment. Complications of sensorineuralhearing loss (SHL) after bacterial meningitis (BM)in children were studied using screening observation ofpatients who had BM from 2015 to 2018. A cohort studywas conducted to detect CHT in patients with meningitisafter discharge with the mandatory audiological examination.Out of all 167 treated children, 103 children underwentan audiological examination, with a diagnosis of“Bacterial meningitis” – 60.7% (n = 65) and “Enterovirusmeningitis” - 73.3% (n = 52). Patients were monitoredfor 1 year, the corresponding clinical history data, a diagnosticprocedure, preoperative imaging data, the timeinterval between the diagnosis of bilateral deafness andcochlear implantation, computed tomography data withfibrosis or ossification were taken. Evaluation of hearingwas evaluated based on the latest available results of puretone and speech audiometry for children

Comprehensive Treatment of Combined Toxoplasmotic-chlamydial Infection in Women

The article analyses various modes of comprehensive treatment of patients with combined toxoplasmotic-chlamydial infection. Combined toxoplasmotic-chlamydial infection in 78 examined patients characterized by polymorphism of clinical aspects. The paper presents results of treatment of patients with mixed infection toxoplasmosis + chlamidiosis, which have sequentially received drugs: combined antiprotozoal drug, antibiotics and immunomodulator. The efficiency of combined treatment of toxoplasmotic-chlamydial infection depends on the composite use of etiotropic and pathogenetic therapy

Medical Sciences Медицинские науки UDC 616.96-085 Comprehensive Treatment of Combined Toxoplasmotic-chlamydial Infection in Women 1

Abstract. The article analyses various modes of comprehensive treatment of patients with combined toxoplasmotic-chlamydial infection. Combined toxoplasmotic-chlamydial infection in 78 examined patients characterized by polymorphism of clinical aspects. The paper presents results of treatment of patients with mixed infection toxoplasmosis + chlamidiosis, which have sequentially received drugs: combined antiprotozoal drug, antibiotics and immunomodulator. The efficiency of combined treatment of toxoplasmotic-chlamydial infection depends on the composite use of etiotropic and pathogenetic therapy

Whole genome sequence analysis of Neisseria meningitidis strains circulating in Kazakhstan, 2017–2018

Neisseria meningitidis (meningococcus) is a cosmopolitan bacterium that is often found in the upper respiratory tract of asymptomatic humans. However, N. meningitidis also causes meningeal inflammation and/or sepsis in humans with a periodic resurgence in incidence and high mortality rates. The pathogen is highly diverse genetically and antigenically, so that genotyping is considered important for vaccine matching to circulating strains. Annual incidence of meningococcal disease in Kazakhstan ranges between 0.2 and 2.5 cases per 100 thousand population. In total, 78 strains of N. meningitidis were isolated from clinical patients and contact persons during the years 2017–2018 in Kazakhstan. Of these, 41 strains including four from the patients and 37 from contacts, were sequenced using Illumina MiSeq. In silico typing was completed using the Neisseria pipeline 1.2 on the Galaxy Workflow Management System and PubMLST. Whole genome SNP (single nucleotide polymorphisms) trees were built using BioNumerics 8. Seven-gene multilocus sequence typing (MLST) identified ten sequence types (ST), two of which have not been previously described (ST-16025; ST-16027). ST-16025 was detected in two patients with invasive meningococcal disease in 2017 and 2018 in Akmola region and 16 contacts in 2017 in Turkistan region. This prevalent type ST-16025 demonstrates considerable intertypic diversity as it consists of three subcomplexes with a distance of more than 2000 SNPs. Invasive and carrier strains belong to different serogroups (MenB and MenC), PorA and FetA_VR. Two invasive strains were MenB, one MenC and one MenW (Hajj lineage). The strains from the contact persons were: MenC (n = 18), cnl (n = 9), MenY (n = 7), MenW (n = 1), MenB (n = 1) and one unidentifiable. Different numbers of alleles were present: 12, 11, 7, and 7 alleles for PorA, FetA, fHbp, and NHBA, respectively. This study is the first report of the genetic diversity of N. meningitidis strains in Kazakhstan. Despite limitations with the studied sample size, important conclusions can be drawn based on data produced. This study provides evidence for regulatory authorities with regard to changing routine diagnostic protocols to increase the collecting of samples for WGS