Patients characteristics.

<p>Patients characteristics.</p

Spearman's rank correlation coefficient, |p|, between PET and CT perfusion parameters and theirs associated p-values for stage III/IV patients.

<p>Spearman's rank correlation coefficient, |p|, between PET and CT perfusion parameters and theirs associated p-values for stage III/IV patients.</p

Heterogeneity analysis process.

<p>Illustration of heterogeneity analysis process: in upper an example of tumor (PET/CT with transverse, coronal and sagittal view), at the bottom: illustration of the FLAB delineation after a manual ROI selection that allows heterogeneity analysis.</p

Texture type, scale and associated features.

<p>Texture type, scale and associated features.</p

Correlation between PET heterogeneity and BF.

<p>Scatter diagrams with regression line (solid line) and associated 95% CI (curves above and below regression line represented upper and lower bounds of 95% CI) showing the correlation of BF with A) IV (|ρ| = 0.75, 95%CI: 0.35 to 0.92, p = 0.02), B) local homogeneity (|ρ| = 0.78, 95%CI: 0.40 to 0.93, p = 0.01), C) MATV (|ρ| = 0.71, 95%CI: 0.26 to 0.90, p = 0.05) in stage III/IV tumors.</p

Positively Charged Lanthanide Complexes with Cyclen-Based Ligands: Synthesis, Solid-State and Solution Structure, and Fluoride Interaction

The syntheses of a new cyclen-based ligand <b>L²</b> containing four <i>N</i>-[2-(2-hydroxyethoxy)­ethyl]­acetamide pendant arms and of its lanthanide­(III) complexes [Ln<b>L²</b>(H₂O)]­Cl₃ (Ln = La, Eu, Tb, Yb, or Lu) are reported, together with a comparison with some Ln^III complexes of a previously reported analogue <b>L¹</b> in which two opposite amide arms have been replaced by coordinating pyridyl units. The structure and dynamics of the La^III, Lu^III, and Yb^III complexes in solution were studied by using multinuclear NMR investigations and density functional theory calculations. Luminescence lifetime measurements in H₂O and D₂O solutions of the [Ln­(<b>L²</b>)­(H₂O)]³⁺ complexes (Ln = Eu or Tb) were used to investigate the number of H₂O molecules coordinated to the metal ion, pointing to the presence of an inner-sphere H₂O molecule in a buffered aqueous solution. Fluoride binding to the latter complexes was investigated using a combination of absorption spectroscopy and steady-state and time-resolved luminescence spectroscopy, pointing to a surprisingly weak interaction in the case of <b>L²</b> (log <i>K</i> = 1.4 ± 0.1). In contrast to the results in solution, the X-ray crystal structure of the lanthanide complex showed the ninth coordination position occupied by a chloride anion. In the case of <b>L¹</b>, the X-ray structure of the [(Eu<b>L¹</b>)₂F] complex features a bridging fluoride donor with an uncommon linear Eu–F–Eu entity connecting two almost identical [Eu­(<b>L¹</b>)]³⁺ units. Encapsulation of the F^– anion within the two complexes is assisted by π–π stacking between the pyridyl rings of two complexes and C–H···F hydrogen-bonding interactions involving the anion and the pyridyl units

Positively Charged Lanthanide Complexes with Cyclen-Based Ligands: Synthesis, Solid-State and Solution Structure, and Fluoride Interaction

The syntheses of a new cyclen-based ligand <b>L²</b> containing four <i>N</i>-[2-(2-hydroxyethoxy)­ethyl]­acetamide pendant arms and of its lanthanide­(III) complexes [Ln<b>L²</b>(H₂O)]­Cl₃ (Ln = La, Eu, Tb, Yb, or Lu) are reported, together with a comparison with some Ln^III complexes of a previously reported analogue <b>L¹</b> in which two opposite amide arms have been replaced by coordinating pyridyl units. The structure and dynamics of the La^III, Lu^III, and Yb^III complexes in solution were studied by using multinuclear NMR investigations and density functional theory calculations. Luminescence lifetime measurements in H₂O and D₂O solutions of the [Ln­(<b>L²</b>)­(H₂O)]³⁺ complexes (Ln = Eu or Tb) were used to investigate the number of H₂O molecules coordinated to the metal ion, pointing to the presence of an inner-sphere H₂O molecule in a buffered aqueous solution. Fluoride binding to the latter complexes was investigated using a combination of absorption spectroscopy and steady-state and time-resolved luminescence spectroscopy, pointing to a surprisingly weak interaction in the case of <b>L²</b> (log <i>K</i> = 1.4 ± 0.1). In contrast to the results in solution, the X-ray crystal structure of the lanthanide complex showed the ninth coordination position occupied by a chloride anion. In the case of <b>L¹</b>, the X-ray structure of the [(Eu<b>L¹</b>)₂F] complex features a bridging fluoride donor with an uncommon linear Eu–F–Eu entity connecting two almost identical [Eu­(<b>L¹</b>)]³⁺ units. Encapsulation of the F^– anion within the two complexes is assisted by π–π stacking between the pyridyl rings of two complexes and C–H···F hydrogen-bonding interactions involving the anion and the pyridyl units

Positively Charged Lanthanide Complexes with Cyclen-Based Ligands: Synthesis, Solid-State and Solution Structure, and Fluoride Interaction

The syntheses of a new cyclen-based ligand <b>L²</b> containing four <i>N</i>-[2-(2-hydroxyethoxy)­ethyl]­acetamide pendant arms and of its lanthanide­(III) complexes [Ln<b>L²</b>(H₂O)]­Cl₃ (Ln = La, Eu, Tb, Yb, or Lu) are reported, together with a comparison with some Ln^III complexes of a previously reported analogue <b>L¹</b> in which two opposite amide arms have been replaced by coordinating pyridyl units. The structure and dynamics of the La^III, Lu^III, and Yb^III complexes in solution were studied by using multinuclear NMR investigations and density functional theory calculations. Luminescence lifetime measurements in H₂O and D₂O solutions of the [Ln­(<b>L²</b>)­(H₂O)]³⁺ complexes (Ln = Eu or Tb) were used to investigate the number of H₂O molecules coordinated to the metal ion, pointing to the presence of an inner-sphere H₂O molecule in a buffered aqueous solution. Fluoride binding to the latter complexes was investigated using a combination of absorption spectroscopy and steady-state and time-resolved luminescence spectroscopy, pointing to a surprisingly weak interaction in the case of <b>L²</b> (log <i>K</i> = 1.4 ± 0.1). In contrast to the results in solution, the X-ray crystal structure of the lanthanide complex showed the ninth coordination position occupied by a chloride anion. In the case of <b>L¹</b>, the X-ray structure of the [(Eu<b>L¹</b>)₂F] complex features a bridging fluoride donor with an uncommon linear Eu–F–Eu entity connecting two almost identical [Eu­(<b>L¹</b>)]³⁺ units. Encapsulation of the F^– anion within the two complexes is assisted by π–π stacking between the pyridyl rings of two complexes and C–H···F hydrogen-bonding interactions involving the anion and the pyridyl units