1,287 research outputs found
Synergistic Gravity and the Role of Resonances in GRS-Inspired Braneworlds
We consider 5D braneworld models of quasi-localized gravity in which 4D
gravity is reproduced at intermediate scales while the extra dimension opens up
at both the very short and the very long distances, where the geometry is flat.
Our main interest is the interplay between the zero mode of these models,
whenever a normalizable zero mode exists, and the effects of zero energy
graviton resonant modes coming from the contributions of massive KK modes. We
first consider a compactified version of the GRS model and find that
quasi-localized gravity is characterized by a scale for which both the
resonance and the zero mode have significant contribution to 4D gravity. Above
this scale, gravity is primarily mediated by the zero mode, while the resonance
gives only minor corrections. Next, we consider an asymmetric version of the
standard non-compact GRS model, characterized by different cosmological
constants on each AdS side. We show that a resonance is present but the
asymmetry, through the form of the localizing potential, can weaken it,
resulting in a shorter lifetime and, thus, in a shorter distance scale for 4D
gravity. As a third model exhibiting quasi-localization, we consider a version
of the GRS model in which the central positive tension brane has been replaced
by a configuration of a scalar field propagating in the bulk.Comment: 18 pages, 3 figures, added 1 figure, revised version as published in
Class. Quant. Gra
Orexin-A exerts equivocal role in atherosclerosis process depending on the duration of exposure : in vitro study
Orexin-A is a peptide hormone that plays a crucial role in feeding regulation and energy homeostasis. Diurnal intermittent fasting (DIF) has been found to increase orexin-A plasma levels during fasting hours, while Ramadan fasting which resembles DIF, has led to beneficial effects on endothelial function. Herein, we aimed to investigate the effects of orexin-A on the expression of molecules involved in the atherogenesis process: Monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase-1 and 2 (TIMP-1 and TIMP-2), in human aortic endothelial cells (HAECs). HAECs were incubated with orexin-A at concentrations of 40 ng/mL, 200 ng/mL and 400 ng/mL for 6, 12 and 24 h. The mRNA levels of MCP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 and orexin-1 receptor were measured by real-time qPCR. We also evaluated the MMP-2, p38, phospho-p38, NF-κΒ/p65 as well as TIMP-1 protein levels by Western blot and ELISA, respectively. MMP-2 activity was measured by gelatin zymography. Short-term 6-h incubation of HAECs with orexin-A at a high concentration (400 ng/mL) decreased MCP-1, MMP-2 expression, MMP-2/TIMP-1 ratio (p < 0.05), and MMP-2 activity, while incubation for 24 h increased MCP-1, MMP-2 expression (p < 0.05), MMP-2/TIMP-1 and MMP-2/TIMP-2 ratio (p < 0.01 and p < 0.05, respectively) as well as MMP-2 activity. The dual effects of orexin-A are mediated, at least in part, via regulation of p38 and NF-κΒ pathway. Orexin-A may have an equivocal role in atherosclerosis process with its effects depending on the duration of exposure
Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour
We report the case of a 79-year-old male with previous history of non-Hodgkin's lymphoma in remission, who presented acutely to the Accident and Emergency department with recurrent episodes of hypoglycaemia. At the time of presentation, a random glucose was low at 1.4 mmol/l, which upon correction resolved his symptoms. In hindsight, the patient recalled having had similar episodes periodically over the past 2 months to which he did not give much notice. While hospitalized, he continued having episodes of symptomatic hypoglycaemia, requiring treatment with intravenous dextrose and per os steroids. Once stable, he was discharged on oral prednisolone and dietary advice. A computed tomography scan performed during inpatient stay showed multiple deposits in the abdomen. An ultrasound guided biopsy of one of the liver deposits was performed. Immunohistochemistry supported the diagnosis of a gastrointestinal stromal tumour (GIST) positive for CD34 and CD117. The diagnosis of non-islet cell tumour hypoglycaemia (NICTH) secondary to an IGF2 secreting GIST was confirmed with further biochemical investigations (IGF2=105.9 nmol/l; IGF2:IGF1 ratio 23, Upper Level of Normal (ULN) <10). Targeted cytoreductive treatment with Imatinib mesylate following assessment of the tumour's mutational status was successful in preventing hypoglycaemia over a 21-month follow-up observation period
Enhanced Design of Narrowband Filters Based on The Extraordinary Transmission Through Single Fishnet Structures
A systematic method for the efficient design of narrowband filters founded on the extraordinary transmission via single fishnet structures (SFSs) is presented in this paper. Essentially, due to its strong resonant behavior, this phenomenon is proven suitable for the implementation of high-Q devices. The new design formulas are derived through the combination of full-wave numerical simulations and curve fitting algorithms. Also, adequate mathematical criteria are defined for the evaluation of the filters\u27 linear performance, indicating that the transmitted electromagnetic waves remain practically undistorted in the frequency band of interest. Then, by exploiting the previously developed relations, proper correction factors are introduced in the existing SFS equivalent circuit expressions, which hardly increase the overall computational complexity. This quantitative modification leads to an enhanced characterization of SFSs, as key components for diverse applications. Finally, several limitations as well as possible ways of extending the featured algorithm to more complicated structures and higher frequency bands are briefly discussed
Laparoscopic adjustable gastric banding – should a second chance be given?
Background:
Obesity is a chronic relapsing-remitting disease and a global pandemic, being associated with multiple comorbidities. Laparoscopic adjustable gastric banding (LAGB) is one of the safest surgical procedures used for the treatment of obesity, and even though its popularity has been decreasing over time, it still remains an option for a certain group of patients, producing considerable weight loss and improvement in obesity-associated comorbidities.
Methods:
The aim of this study was to evaluate the impact of weight loss following LAGB on obesity-associated comorbidities, and to identify factors that could predict better response to surgery, and patient sub-groups exhibiting greatest benefit. A total of 99 severely obese patients (81.2% women, mean age 44.19 ± 10.94 years, mean body mass index (BMI) 51.84 ± 8.77 kg/m2) underwent LAGB in a single institution. Results obtained 1, 2, and 5 years postoperatively were compared with the pre-operative values using SPPS software version 20.
Results:
A significant drop in BMI was recorded throughout the follow-up period, as well as in A1c and triglycerides, with greatest improvement seen 2 years after surgery (51.8 ± 8.7 kg/m2 vs 42.3 ± 9.2 kg/m2, p < 0.05, 55.5 ± 19.1 mmol/mol vs 45.8 ± 13.7 mmol/mol, p < 0.05, and 2.2 ± 1.7 mmol/l vs 1.5 ± 0.6 mmol/l). Better outcomes were seen in younger patients, with lower duration of diabetes before surgery, and lower pre-operative systolic blood pressure.
Conclusions:
Younger age, lower degree of obesity, and lower severity of comorbidities at the time of surgery can be important predictors of successful weight loss, making this group of patients the ideal candidates for LAGB
DGP Cosmology with a Non-Minimally Coupled Scalar Field on the Brane
We construct a DGP inspired braneworld scenario where a scalar field
non-minimally coupled to the induced Ricci curvature is present on the brane.
First we investigate the status of gravitational potential with non-minimal
coupling and observational constraints on this non-minimal model. Then we
further deepen the idea of embedding of FRW cosmology in this non-minimal
setup. Cosmological implications of this scenario are examined with details and
the quintessence and late-time expansion of the universe within this framework
are examined. Some observational constraints imposed on this non-minimal
scenario are studied and relation of this model with dark radiation formalism
is determined with details.Comment: 26 pages, 3 eps figure
Severe paraneoplastic hypoglycemia secondary to a gastrointestinal stromal tumour masquerading as a stroke
We report the case of a 70-year-old previously healthy female who presented acutely to the Accident and Emergency department with left-sided vasomotor symptoms including reduced muscle tone, weakness upon walking and slurred speech. Physical examination confirmed hemiparesis with VIIth nerve palsy and profound hepatomegaly. A random glucose was low at 1.7 mmol/l, which upon correction resolved her symptoms. In hindsight, the patient recalled having had similar episodes periodically over the past 3 months to which she did not give much attention. While hospitalized, she continued having episodes of symptomatic hypoglycaemia during most nights, requiring treatment with i.v. dextrose and/or glucagon. Blood tests including insulin and C-peptide were invariably suppressed, in correlation with low glucose. A Synacthen stimulation test was normal (Cort (0′) 390 nmol/l, Cort (30′) 773 nmol/l). A computed tomography scan showed multiple lobulated masses in the abdomen, liver and pelvis. An ultrasound guided biopsy of one of the pelvic masses was performed. Immunohistochemistry supported the diagnosis of a gastrointestinal stromal tumour (GIST) positive for CD34 and CD117. A diagnosis of a non islet cell tumour hypoglycaemia (NICTH) secondary to an IGF2 secreting GIST was confirmed with further biochemical investigations (IGF2=96.5 nmol/l; IGF2:IGF1 ratio 18.9, ULN <10). Treatment with growth hormone resolved the patient's hypoglycaemic symptoms and subsequent targeted therapy with Imatinib was successful in controlling disease progression over an 8-year observation period
Using late-time optical and near-infrared spectra to constrain Type Ia supernova explosion properties
The late-time spectra of Type Ia supernovae (SNe Ia) are powerful probes of
the underlying physics of their explosions. We investigate the late-time
optical and near-infrared spectra of seven SNe Ia obtained at the VLT with
XShooter at 200 d after explosion. At these epochs, the inner Fe-rich ejecta
can be studied. We use a line-fitting analysis to determine the relative line
fluxes, velocity shifts, and line widths of prominent features contributing to
the spectra ([Fe II], [Ni II], and [Co III]). By focussing on [Fe II] and [Ni
II] emission lines in the ~7000-7500 \AA\ region of the spectrum, we find that
the ratio of stable [Ni II] to mainly radioactively-produced [Fe II] for most
SNe Ia in the sample is consistent with Chandrasekhar-mass delayed-detonation
explosion models, as well as sub-Chandrasekhar mass explosions that have
metallicity values above solar. The mean measured Ni/Fe abundance of our sample
is consistent with the solar value. The more highly ionised [Co III] emission
lines are found to be more centrally located in the ejecta and have broader
lines than the [Fe II] and [Ni II] features. Our analysis also strengthens
previous results that SNe Ia with higher Si II velocities at maximum light
preferentially display blueshifted [Fe II] 7155 \AA\ lines at late times. Our
combined results lead us to speculate that the majority of normal SN Ia
explosions produce ejecta distributions that deviate significantly from
spherical symmetry.Comment: 17 pages, 12 figure, accepted for publication in MNRA
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