Locations of -homocysteic acid injection sites in ventrolateral (VL) and dorsolateral/lateral (DL/L) periaqueductal grey (PAG)

<p><b>Copyright information:</b></p><p>Taken from "Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat"</p><p></p><p>The European Journal of Neuroscience 2007;26(4):943-952.</p><p>Published online Jan 2007</p><p>PMCID:PMC2121136.</p><p>© The Authors (2007). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</p> (A) Representative transverse sections to illustrate all injection sites in the VL- and DL/L-PAG. Locations of injections in control (group C) and experimental (group B) animals are shown in black and shades of grey, respectively. (B) Photomicrographs of individual examples of injection sites in VL- and DL/L-PAG. Insets are examples of evoked changes in blood pressure (mmHg). Aq, Aqueduct

Familial Chordoma, a Tumor of Notochordal Remnants, Is Linked to Chromosome 7q33

Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during midlife. We performed a genomewide analysis for linkage in a family with 10 individuals affected by chordoma. The maximum two-point LOD score based on only the affected individuals was 2.21, at recombination fraction 0, at marker D7S2195 on chromosome 7q. Combined analysis of additional members of this family (11 affected individuals) and of two unrelated families (one with 2 affected individuals and the other with 3 affected individuals), with 20 markers on 7q, showed a maximum two-point LOD score of 4.05 at marker D7S500. Multipoint analysis based on only the affected individuals gave a maximum LOD score of 4.78, with an approximate 2-LOD support interval from marker D7S512 to marker D7S684. Haplotype analysis of the three families showed a minimal disease-gene region from D7S512 to D7S684, a distance of 11.1 cM and ∼7.1 Mb. No loss of heterozygosity was found at markers D7S1804, D7S1824, and D7S2195 in four tumor samples from affected family members. These results map a locus for familial chordoma to 7q33. Further analysis of this region, to identify this gene, is ongoing

Effects of activation in the periaqueductal grey (PAG) on Fos-like immunoreactivity in the dorsal horn

<p><b>Copyright information:</b></p><p>Taken from "Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat"</p><p></p><p>The European Journal of Neuroscience 2007;26(4):943-952.</p><p>Published online Jan 2007</p><p>PMCID:PMC2121136.</p><p>© The Authors (2007). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</p> Histograms of median numbers per 10 40 µm sections of Fos-positive neurones in laminae (Lam) I and II and Lam III–VI in response to fast (A and C) and slow (B and D) rates of skin heating with and without the influence of descending control exerted by different sectors of the PAG [A and B, ventrolateral (VL) PAG; C and D, dorsolateral/lateral (DL/L) PAG]. Numbers of Fos-positive neurones in the absence and presence of descending control from the PAG are shown by open and filled bars, respectively. * < 0.05, ** < 0.01, *** < 0.001