4 research outputs found
William Logan Fisher (1781-1862)
William Logan Fisher, industrialist, author, and Philadelphia patriarch bought the Belfield estate from the Peale family in 1826. He lived at Wakefield and established the Wakefield Mills Manufacturing Company. In its prime, the Wakefield Mills, powered by steam and water, produced an estimated nine-tenths of all hosiery and fancy knit goods in the United States.https://digitalcommons.lasalle.edu/people_places/1000/thumbnail.jp
Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms
Various organisms (i.e., bacteria, fungi, plants and animals) within an ecosystem can synthesize and release into the environment certain longevity-extending small molecules. Here we hypothesize that these interspecies chemical signals can create xenohormetic, hormetic and cytostatic selective forces driving the ecosystemic evolution of longevity regulation mechanisms. In our hypothesis, following their release into the environment by one species of the organisms composing an ecosystem, such small molecules can activate anti-aging processes and/or inhibit pro-aging processes in other species within the ecosystem. The organisms that possess the most effective (as compared to their counterparts of the same species) mechanisms for sensing the chemical signals produced and released by other species and for responding to such signals by undergoing certain hormetic and/or cytostatic life-extending changes to their metabolism and physiology are expected to live longer then their counterparts within the ecosystem. Thus, the ability of a species of the organisms composing an ecosystem to undergo life-extending metabolic or physiological changes in response to hormetic or cytostatic chemical compounds released to the ecosystem by other species: 1) increases its chances of survival; 2) creates selective forces aimed at maintaining such ability; and 3) enables the evolution of longevity regulation mechanisms
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The microenvironment dictates glycocalyx construction and immune surveillance
Summary:
Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built within vitromodels that do not match the microenvironmental characteristics of human tissues. Usingin vitromodels which mimic the physical properties of healthy or cancerous tissues and a physiologically relevant culture medium, we demonstrate that the chemical and physical properties of the microenvironment regulate the composition and topology of the glycocalyx. Remarkably, we find that cancer and age-related changes in the physical properties of the microenvironment are sufficient to adjust immune surveillance via the topology of the glycocalyx, a previously unknown phenomenon observable only with a physiologically relevant culture medium.
Key Points:
Culture medium dictates cellular mechanoresponse signatures in vitro
Epithelial glycocalyx construction is mediated by Heat Shock Factor 1 (HSF1)
Sialic acid topology dictates Natural Killer cell cytotoxicity
Physiological microenvironments reveal distinct glycobiolog