Deep scattering layer in the Pacific and Antarctic Oceans

During Operation HIGHJUMP (U. S. Navy Antarctic Development Project, 1947), the writer frequently noted the presence of a layer of deep scatterers on the fathogram of the USS HENDERSON. This layer partially scatters the outgoing sound signal of the recording echo sounder during daylight hours so that a reflection is recorded which has the appearance of a false bottom at various depths between 150 and 450 fathoms

Sudbury Breccia and suevite as glacial indicators transported 800 km to Kentland Astrobleme, Indiana

A glacial erratic whose place of origin is known by direct comparison with bedrock is known as an indicator. In 1971, while visiting the known astrobleme at Kentland, Indiana, Peredery recognized and sampled in the overlying glacial drift deposits a distinctive boulder of Sudbury suevite (black member, Onaping Formation) that normally occurs within the Sudbury Basin as an impact fall-back or wash-in deposit. The rock was sampled (but later mislaid) from a farmer's cairn next to a cleared field. Informal reports of this discovery prompted the other authors to recently reconnoiter the Kentland locality in an attempt to relocate the original boulder. Several breccia blocks were sampled but laboratory examination proved most of these probably to be diamictites from the Precambrian Gowganda Formation, which outcrops extensively in the southern Ontario. However, one sample was confirmed as typical Sudbury Breccia, which outcrops in the country rock surrounding the Sudbury Basin. Thus two glacial indicators were transported by Pleistocene continental glaciers about 820 km over a tightly proscribed path and, curiously, from one astrobleme to another. Brecciated boulders in the Illinois/Indiana till plain are usually ascribed to the Gowganda or Mississagi formations in Ontario. But impact-generated rocks need not be confused. The carbonaceous matrix of the suevite, for example, was sufficiently distinctive to assign it to the upper portion of the black Onaping. The unique and restricted source area of these indicators provide an accurate and reliable control for estimating Pleistocene ice movement

Two-stage athermal solidification of semiflexible polymers and fibers

We study how solidification of model freely rotating polymers under athermal quasistatic compression varies with their bond angle $\theta_0$. All systems undergo two discrete, first-order-like transitions: entanglement at $\phi = \phi_E(\theta_0)$ followed by jamming at $\phi = \phi_J(\theta_0) \simeq (4/3 \pm 1/10)\phi_E(\theta_0)$. For $\phi < \phi_E(\theta_0)$, systems are in a "gas" phase wherein all chains remain free to translate and reorient. For $\phi_E(\theta_0) \leq \phi \leq \phi_J(\theta_0)$, systems are in a liquid-like phase wherein chains are entangled. In this phase, chains' rigid-body-like motion is blocked, yet they can still locally relax via dihedral rotations, and hence energy and pressure remain extremely small. The ability of dihedral relaxation mechanisms to accommodate further compression becomes exhausted, and systems rigidify, at $\phi_J(\theta_0)$. At and slightly above $\phi_J$, the bulk moduli increase linearly with the pressure $P$ rather than jumping discontinuously, indicating these systems solidify via rigidity percolation. The character of the energy and pressure increases above $\phi_J(\theta_0)$ can be characterized via chains' effective aspect ratio $\alpha_{\rm eff}$. Large-$\alpha_{\rm eff}$ (small-$\theta_0$) systems' jamming is bending-dominated and is similar to that observed in systems composed of straight fibers. Small-$\alpha_{\rm eff}$ (large-$\theta_0$) systems' jamming is dominated by the degree to which individual chains' dihedrals can collapse into compact, tetrahedron-like structures. For intermediate $\theta_0$, chains remain in highly disordered globule-like configurations throughout the compression process; jamming occurs when entangled globules can no longer even locally relax away from one another

Natural slicks on the ocean

Slicks are smooth glassy streaks or patches on the ocean. Prominent slicks are confined largely to near-shore areas where organic production is high. Experiments and observations are described which show that slicks are contaminate films of organic oil, probably derived primarily from diatoms which contain droplets of oil in their cells to assist in flotation and/or as an emergency food supply. Slicks are discernible because of their damping effect on small wavelets. The parallel slicks that develop in light to moderate winds result because the contaminate films pile up at the top of convergences in the homogeneous, wind-stirred layer above the thermocline

The prognostic value of the hypoxia markers CA IX and GLUT 1 and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy ± chemotherapy

BACKGROUND: Several parameters of the tumor microenvironment, such as hypoxia, inflammation and angiogenesis, play a critical role in tumor aggressiveness and treatment response. A major question remains if these markers can be used to stratify patients to certain treatment protocols. The purpose of this study was to investigate the inter-relationship and the prognostic significance of several biological and clinicopathological parameters in patients with head and neck squamous cell carcinoma (HNSCC) treated by radiotherapy ± chemotherapy. METHODS: We used two subgroups of a retrospective series for which CT-determined tumoral perfusion correlated with local control. In the first subgroup (n = 67), immunohistochemistry for carbonic anhydrase IX (CA IX) and glucose transporter-1 (GLUT-1) was performed on the pretreatment tumor biopsy. In the second subgroup (n = 34), enzyme linked immunosorbent assay (ELISA) was used to determine pretreatment levels of the cytokines vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in serum. Correlation was investigated between tumoral perfusion and each of these biological markers, as well as between the markers mutually. The prognostic value of these microenvironmental parameters was also evaluated. RESULTS: For CA IX and GLUT-1, the combined assessment of patients with both markers expressed above the median showed an independent correlation with local control (p = 0.02) and disease-free survival (p = 0.04) with a trend for regional control (p = 0.06). In the second subgroup, IL-6 pretreatment serum level above the median was the only independent predictor of local control (p = 0.009), disease-free survival (p = 0.02) and overall survival (p = 0.005). CONCLUSION: To our knowledge, we are the first to report a link in HNSCC between IL-6 pretreatment serum levels and radioresistance in vivo. This link is supported by the strong prognostic association of pretreatment IL-6 with local control, known to be the most important parameter to judge radiotherapy responses. Furthermore, the combined assessment of CA IX and GLUT-1 correlated independently with prognosis. This is a valuable indication that a combined approach is important in the investigation of prognostic markers

Immunogenicity and protective efficacy of nanoparticle formulations of L-SseB against Salmonella infection

Salmonella enterica, a Gram-negative pathogen, has over 2500 serovars that infect a wide range of hosts. In humans, S. enterica causes typhoid or gastroenteritis and is a major public health concern. In this study, SseB (the tip protein of the Salmonella pathogenicity island 2 type III secretion system) was fused with the LTA1 subunit of labile-toxin from enterotoxigenic E. coli to make the self-adjuvanting antigen L-SseB. Two unique nanoparticle formulations were developed to allow multimeric presentation of L-SseB. Mice were vaccinated with these formulations and protective efficacy determined via challenging the mice with S. enterica serovars. The polysaccharide (chitosan) formulation was found to elicit better protection when compared to the squalene nanoemulsion. When the polysaccharide formulation was used to vaccinate rabbits, protection from S. enterica challenge was elicited. In summary, L-SseB in a particulate polysaccharide formulation appears to be an attractive candidate vaccine capable of broad protection against S. enterica

Do Organohalogen Contaminants Contribute to Histopathology in Liver from East Greenland Polar Bears (Ursus maritimus)?

In East Greenland polar bears (Ursus maritimus), anthropogenic organohalogen compounds (OHCs) (e.g., polychlorinated biphenyls, dichlorodiphenyltrichloroethane, and polybrominated diphenyl ethers) contributed to renal lesions and are believed to reduce bone mineral density. Because OHCs are also hepatotoxic, we investigated liver histology of 32 subadult, 24 adult female, and 23 adult male East Greenland polar bears sampled during 1999–2002. Light microscopic changes consisted of nuclear displacement from the normal central cytoplasmic location in parenchymal cells, mononuclear cell infiltrations (mainly portally and as lipid granulomas), mild bile duct proliferation accompanied by fibrosis, and fat accumulation in hepatocytes and pluripotent Ito cells. Lipid accumulation in Ito cells and bile duct hyperplasia accompanied by portal fibrosis were correlated to age, whereas no changes were associated with either sex or season (summer vs. winter). For adult females, hepatocytic intracellular fat increased significantly with concentrations of the sum of hexachlorocyclohexanes, as was the case for lipid granulomas and hexachlorobenzene in adult males. Based on these relationships and the nature of the chronic inflammation, we suggest that these findings were caused by aging and long-term exposure to OHCs. Therefore, these changes may be used as biomarkers for OHC exposure in wildlife and humans. To our knowledge, this is the first time liver histology has been evaluated in relation to OHC concentrations in a mammalian wildlife species, and the information is important to future polar bear conservation strategies and health assessments of humans relying on OHC-contaminated food resources