Techniques for Consecutive TEM and Atom Probe Tomography Analysis of Nanowires

Nanowires show great promise for development in many technological applications including electronics, photonics, and displays . Due to the fine scale of nanowires, transmission electron microscopy (TEM) and atom probe tomography (APT) are among a limited number of techniques that can measure the crystallographic and chemical nature of these structures which ultimately define their performance

Techniques for Consecutive TEM and Atom Probe Tomography Analysis of Nanowires

Nanowires show great promise for development in many technological applications including electronics, photonics, and displays . Due to the fine scale of nanowires, transmission electron microscopy (TEM) and atom probe tomography (APT) are among a limited number of techniques that can measure the crystallographic and chemical nature of these structures which ultimately define their performance

The Cosmic Gamma-Ray Bursts

Cosmic gamma-ray bursts are one of the great frontiers of astrophysics today. They are a playground of relativists and observers alike. They may teach us about the death of stars and the birth of black holes, the physics in extreme conditions, and help us probe star formation in the distant and obscured universe. In this review we summarise some of the remarkable progress in this field over the past few years. While the nature of the GRB progenitors is still unsettled, it now appears likely that at least some bursts originate in explosions of very massive stars, or at least occur in or near the regions of massive star formation. The physics of the burst afterglows is reasonably well understood, and has been tested and confirmed very well by the observations. Bursts are found to be beamed, but with a broad range of jet opening angles; the mean gamma-ray energies after the beaming corrections are ~ 10^51 erg. Bursts are associated with faint ~ 25 mag) galaxies at cosmological redshifts, with ~ 1. The host galaxies span a range of luminosities and morphologies, but appear to be broadly typical for the normal, actively star-forming galaxy populations at comparable redshifts and magnitudes. Some of the challenges for the future include: the nature of the short bursts and possibly other types of bursts and transients; use of GRBs to probe the obscured star formation in the universe, and possibly as probes of the very early universe; and their detection as sources of high-energy particles and gravitational waves.Comment: An invited review, to appear in: Proc. IX Marcel Grossmann Meeting, eds. V. Gurzadyan, R. Jantzen, and R. Ruffini, Singapore: World Scientific, in press (2001); Latex file, 33 pages, 22 eps figures, style files include

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long-duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth. This overview is a combined write-up of talks given at this conference and in NASA's Goddard Space Flight Center

The afterglows of gamma-ray bursts

Gamma-ray burst astronomy has undergone a revolution in the last three years, spurred by the discovery of fading long-wavelength counterparts. We now know that at least the long duration GRBs lie at cosmological distances with estimated electromagnetic energy release of 10^51–10^53 erg, making these the brightest explosions in the Universe. In this article we review the current observational state, beginning with the statistics of X-ray, optical, and radio afterglow detections. We then discuss the insights these observations have given to the progenitor population, the energetics of the GRB events, and the physics of the afterglow emission. We focus particular attention on the evidence linking GRBs to the explosion of massive stars. Throughout, we identify remaining puzzles and uncertainties, and emphasize promising observational tools for addressing them. The imminent launch of HETE-2 and the increasingly sophisticated and coordinated ground-based and space-based observations have primed this field for fantastic growth

GRB 000418: A Hidden Jet Revealed?

We report on optical, near-infrared and centimeter radio observations of GRB000418 which allow us to follow the evolution of the afterglow from 2 to 200 days after the gamma-ray burst. In modeling these broad-band data, we find that an isotropic explosion in a constant density medium is unable to simultaneously fit both the radio and optical data. However, a jet-like outflow with an opening angle of 10-20 degress provides a good description of the data. The evidence in favor of a jet interpretation is based on the behavior of the radio light curves, since the expected jet break is masked at optical wavelengths by the light of the host galaxy. We also find evidence for extinction, presumably arising from within the host galaxy, with A(V)=0.4 mag, and host flux densities of F_R=1.1 uJy and F_K=1.7 uJy. These values supercede previous work on this burst due to the availability of a broad-band data set allowing a global fitting approach. A model in which the GRB explodes into a wind-stratified circumburst medium cannot be ruled out by these data. However, in examining a sample of other bursts (e.g. GRB990510, GRB000301C) we favor the jet interpretation for GRB000418.Comment: ApJ, submitte

Autoantibody detection for diagnosis in direct immunofluorescence negative mucous membrane pemphigoid: ocular and other sites compared

Objective: To assess whether a panel of serum pemphigoid autoantibody tests could be used to confirm an immunopathological diagnosis of mucous membrane pemphigoid (MMP) in direct immunofluorescent negative (DIF-) MMP patients. / Design: Prospective cross-sectional study. / Subjects and controls: 76 patients with MMP involving ocular and non-ocular sites with 45 matched controls. / Tests: Enzyme linked immunosorbent assays (ELISA) for BP180 and BP230 (MBL International®), IgA and IgG indirect immunofluorescence on human salt-split skin (IIF SSS) and the keratinocyte footprint assay for anti-laminin 332 antibodies. / Main outcome measures: Sensitivity and specificity of autoantibody detection; significant differences for individual tests and test combinations for MMP involving different sites. / Results: All DIF- Cases (24/76, 31.8%) had either ocular only disease or ocular involvement in multi-site disease. Serum pemphigoid autoantibodies were detected in 29/76 (38.2%) of all MMP patients compared to 3/45 (6.7%) of controls. Autoantibody reactivity detected by any one or more of the tests was present in 6/24 (25%) DIF- cases compared to 22/49 (44.9%) in DIF positive (DIF+). Compared to controls ocular only MMP serum reactivity was not significantly different for any test or test combination whereas DIF- multisite ocular MMP differed for one ELISA and 3/7 test combinations. By contrast, for DIF+ non ocular MMP all the individual tests, apart from IgA IIF, and all test combinations were significantly different compared to controls. For the whole MMP cohort the sensitivity of all tests was low having a maximum of 21.05% for BP180 reactivity, increasing to 38.16% for an optimal test combination. Disease activity was strongly associated with positive serology findings. / Conclusions: Pemphigoid serum autoantibody tests did not provide alternative immunopathological evidence of MMP in ocular only MMP patients but had limited value in DIF- multisite ocular MMP. The requirement for immunopathological confirmation of MMP by autoantibody detection is inappropriate for DIF- ocular only MMP resulting in missed diagnoses, delayed therapy and poor outcomes. Alternative diagnostic criteria for MMP with ocular involvement are required, to exclude the other causes of scarring conjunctivitis, until more sensitive and specific immunopathology tests become available

Overview of steam generator tube degradation and integrity issues

The degradation of steam generator tubes in pressurized water nuclear reactors continues to be a serious problem. Primary water stress corrosion cracking is commonly observed at the roll transition zone at U-bends, at tube denting locations, and occasionally in plugs and sleeves. Outer-diameter stress corrosion cracking and intergranular attack commonly occur near the tube support plate crevice, near the tube sheet in crevices or under sludge piles, and occasionally in the free span. A particularly troubling recent trend has been the increasing occurrence of circumferential cracking at the RTZ on both the primary and secondary sides. Segmented axial cracking at the tubes support plate crevices is also becoming more common. Despite recent advances in in-service inspection technology, a clear need still exists for quantifying and improving the reliability of in- service inspection methods with respect to the probability of detection of the various types of flaws and their accurate sizing. Improved inspection technology and the increasing occurrence of such degradation modes as circumferential cracking, intergranular attack, and discontinuous axial cracking have led to the formulation of a new performance-based steam generator rule. This new rule would require the development and implementation of a steam generator management program that monitors tube condition against accepted performance criteria to ensure that the tubes perform the required safety function over the next operating cycle. The new steam generator rule will also be applied to severe accident conditions to determine the continued serviceability of a steam generator with degraded tubes in the event of a severe accident. Preliminary analyses are being performed for a hypothetical severe accident scenario to determine whether failure will occur first in the steam generator tubes, which would lead to containment bypass, or instead in the hot leg nozzle or surge line, which would not