Acetabular Peri-Prosthetic Fractures-A Narrative Review.

Acetabular peri-prosthetic fractures are rare but their incidence is rising due to the increased prevalence of total hip arthroplasty, the increasing life expectancy and the growing functional demand of an ageing population, the incidence of primary total hip arthroplasty is increasing. They are either intra-operative or post-operative and have various aetiologies. Several factors such as implant stability, bone loss, remaining bone stock, fracture pattern, timing, age and co-morbidities of the patients must be considered for adequate treatment. To date, the literature on this subject has been sparse and no universally recognized treatment algorithm exists. Their rarity makes them a little-known entity and their surgical management represents a challenge for most orthopaedic surgeons. This review aims to present an update on epidemiology, the diagnostic work up, existing classification systems, surgical approaches and therapeutic options for acetabular peri-prosthetic fractures

Document, create and translate knowledge: the mission of ReFORM, the Francophone IOC Research Centre for Prevention of Injury and Protection of Athlete Health

The International Olympic Committee (IOC) has supported athletes’ health protection by funding Research Centres dedicated to prevention and treatment of sports-related injuries and illnesses. After establishing four centres in 2009, the IOC Research Centres network expanded to 9 Institutions in 2014 and the 2019 round recognised 11 centres. Here we introduce ReFORM — an international French-speaking network of five institutions.Peer reviewe

Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

Subchondral bone modifications occur early in the development of osteoarthritis (OA). The level of bone resorption might impact cartilage remodeling. We therefore assessed the in vivo and in vitro effects of targeting bone resorption in OA and cartilage metabolism.OA was induced by meniscectomy (MNX) in ovariectomized osteopenic mice (OP) treated with estradiol (E2), pamidronate (PAM), or phosphate buffered saline (PBS) for 6 weeks. We assessed the subchondral bone and cartilage structure and the expression of cartilage matrix proteases. To assess the involvement of bone soluble factors in cartilage metabolism, supernatant of human bone explants pre-treated with E2 or PAM were transferred to cartilage explants to assess proteoglycan release and aggrecan cleavage. OPG/RANKL mRNA expression was assessed in bone explants by real-time quantitative PCR. The role of osteoprotegerin (OPG) in the bone-cartilage crosstalk was tested using an OPG neutralizing antibody.Bone mineral density of OP mice and osteoclast number were restored by E2 and PAM (p<0.05). In OP mice, E2 and PAM decreased ADAMTS-4 and -5 expression, while only PAM markedly reduced OA compared to PBS (2.0±0.63 vs 5.2±0.95; p<0.05). OPG/RANKL mRNA was increased in human bone explants treated with both drugs (2.2-3.7-fold). Moreover, supernatants from bone explants cultured with E2 or PAM reduced aggrecan cleavage and cartilage proteoglycan release (73±8.0% and 80±22% of control, respectively, p<0.05). This effect was reversed with osteoprotegerin blockade.The inhibition of bone resorption by pamidronate in osteopenic mice alleviates the histological OA score with a reduction in the expression of aggrecanases. Bone soluble factors, such as osteoprotegerin, impact the cartilage response to catabolic factors. This study further highlights the importance of subchondral bone in the regulation of joint cartilage damage in OA

Peut-on faire du sport avec une prothèse de hanche ou de genou ?

Le remplacement prothétique de la hanche ou du genou donne satisfaction à un grand nombre de patients, permettant aujourd'hui d'étendre les indications à des patients plus jeunes. Les recommandations concernant la reprise du sport reposent sur des avis d'experts et des enquêtes menées auprès de chirurgiens, et classent les activités en activités recommandées, recommandées avec un certain niveau d'expérience et déconseillées. Elles tiennent compte des risques liés à la pratique sportive, mais ne sont pas toujours en phase avec les attentes croissantes des patients. Cet article pose la question des risques associés à la reprise du sport après chirurgie, des sports recommandés ainsi que du taux et du délai de reprise. Le principal facteur prédictif de reprise du sport demeure la motivation du patient et le niveau sportif préopératoire

Contribution à la fabrication de structures cartilagineuses implantables à partir de cellules souches adultes ou foetales et d'un support en acide polyglycolique

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

REPRISE DES PROTHESES TOTALES DE HANCHE ALUMINE-ALUMINE (MODALITES ET RESULTATS AU RECUL MOYEN DE 6 ANS)

PARIS6-Bibl. St Antoine CHU (751122104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF