Quickly diagnosed and treated prepubertal Type 1 narcolepsy case

Excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic hallucination are the classic tetrad of narcolepsy. It has been shown that narcolepsy, a chronic and disabling disease, starts in childhood and adolescence rather than adulthood. The International Classification of Sleep Disorder (ICSD-3) classifies narcolepsy into Type 1 (narcolepsy with cataplexy) and Type 2 (narcolepsy without cataplexy). There is low awareness and knowledge of narcolepsy among the general public, primary care physicians, and sleep specialists. It has been shown that the lack of recognition of disease symptoms delayed the diagnosis of narcolepsy from 8.7 to 22.1 years. In this case report, we will discuss the case of Type 1 narcolepsy, which started in the prepubertal period and was diagnosed and treated in a short period of time

Quality of Life and Associated Risk Factors in Caregivers of Patients with Obsessive Compulsive Disorder

INTRODUCTION: Obsessive compulsive disorder (OCD) is a chronic disease that affects social relationships, and occupational and academic performance of patients and their relatives due to cognitive, emotional, and behavioural aspects of the disease. Quality of life (QoL) in relatives of patients with OCD has previously been reported and compared with caregivers of patients with other psychiatric conditions. However, there are few studies available in the literature regarding the causality of QoL in caregivers of patients with OCD. OBJECTIVE: The aim of this study was to evaluate QoL of caregivers of patients with OCD and predictors of QoL of the family caregivers. METHODS: The study population comprised of 68 patients with OCD and their caregivers. The dependent variable of this study is “QoL of caregivers” as assessed by the short version of the World Health Organization Quality of Life questionnaire (WHOQOL-BREF-TR). The Structured Clinical Interview for DSM-IV/Clinical Version (SCID-I/CV), Yale-Brown obsessive-compulsive scale (Y-BOCS), Y-BOCS symptom checklist, Hamilton Depression Rating Scale (HAM-D), and WHOQOL-BREF-TR were completed by the patients, whereas the SCID-I/CV, WHOQOL-BREF-TR, and Burden Assessment Scale (BAS) were completed by the caregivers. Student’s t-test, MWU, ANOVA, Kruskal–Wallis ANOVA, and Spearman’s correlations were used in univariate analyses, and multiple linear regression tests were run in multivariate analyses. Critical VIF values were taken as 5.0 for detecting collinearity among independent variables in the regression analyses. Type 1 error was taken as 0.05 in the analyses. RESULTS: Linear regression analysis showed that caregivers’ sex, education level, occupational status, disease burden, and patients’ sex, physical QoL, and disease severity were predictors of caregivers’ QoL. Moreover, disease burden was the only common predictor that affected all four dimensions (physical, psychological, social relations, environmental) of the caregiver’s QoL, and as the perceived disease burden increased, the caregiver’s QoL deteriorated

Reliability and validity of Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry

Amaç: Bu çalışmanın amacı Biyolojik Ritim Değerlendirme Görüşmesinin (BRDG) Türkçe sürümünün güvenilirlik ve geçerliliğini ortaya koymaktır. Yöntem: Araştırma üç üniversite hastanesi psikiyatri anabilim dalı ve bir eğitim hasta- nesi duygudurum bozuklukları birimlerine başvuran ve iki uçlu tip I bozukluk tanısı konan 79, iki uçlu tip II bozukluk tanısı konan 26, majör depresif bozukluk tanısı konan 42 hasta ile, üniversite öğrencilerinden oluşan 116 sağlıklı gönüllüden oluşan gruplarla yürütülmüştür. Hastalık süresi iki uçlu bozukluk grupları için 15.1 yıl ve majör depresif bozukluk grubu için 9.3 yıldır. Birlikte geçerliliği değerlendirmek amacıyla Pittsburgh Uyku Kalitesi Ölçeği uygulan- mıştır. İstatistiksel değerlendirmede iç tutarlılık katsayısı, madde-toplam puan bağıntı katsayıları, açıklayıcı ve doğru- layıcı faktör çözümlemesi, diğer ölçekle bağıntı ve ROC eğrisi hesaplanmıştır. Bulgular: BRDG önce Türkçeye, sonra İngilizceye çevrilmiş ve çeviriler sonunda dil birliğiyle ölçek metni elde edilmiştir. İç tutarlılık çözümlemesinde Cron- bach alfa katsayısı 0.899 ve madde-toplam puan bağıntı katsayıları 0.239-0.747 arasında elde edilmiştir. Açıklayıcı faktör çözümlemesinde varyansın %56.5’ini açıklayan toplam üç faktör elde edilmiştir: Günlük etkinlikler, uyku ve yeme alışkanlıkları, kişilerarası ilişkiler. Doğrulayıcı faktör çözümlemesinde karşılaştırmalı uyum endeksi 0.932 ve tahminin ortalama kare kök hatası 0.065 olarak bulunmuştur. BRDG’nin Pittsburgh Uyku Kalitesi Ölçeği ile bağıntısı r=0.238 olarak hesaplanmıştır. Özgüllük ve duyarlılık çözümlemesinde ROC eğrisinin altında kalan alan 0.876 olarak bulunmuştur. Ölçeğin duygudurum bozukluğu gruplarını kontrol grubundan ayırt ettiği görülmüştür. Sonuç: Hastaların günlük döngüsel ritmini ve bu ritime uygun olarak işlevselliğini değerlendirmeye elverişli BRDG’nin Türkçe formunun güvenilir ve geçerli olduğu gösterilmiştir.Objective: In this study, it is aimed to perform the validity and reliability of the Turkish version of Biological Rhythms Interview of Assessment in Neuropsychiatry. Methods: The study was performed with 79 bipolar type-I disorder, 26 bipolar type-II disorder and 42 major depressive disorder patients attending to mood disorder clinics of three university hospitals and one state training hospital as well as 116 university students consisting healthy control subjects. The mean duration of the illness was 15.1 years for the bipolar groups and 9,3 years for the depressive group. For concurrent validity, Pittsburgh Sleep Quality Index was used. In the statistical analyzes, internal consistency coefficient, item-total score correlations, exploratory and confirmatory factor analyzes, correlation with the other scale and ROC curve were calculated. Results: The forward and back translation of the Biological Rhythms Interview of Assessment in Neuropsychiatry was performed, and linguistic equivalence was obtained with the scale prepared. In internal consistency, the Cronbach's alpha coefficient was found to be 0.899 and item-total correlation coefficients <<<<<<<<<<<<<<<<<<<<&lt