5 research outputs found
Bruce Dowbiggin\u27s The Defense Never Rests (book review)
- Publication venue
- eRepository @ Seton Hall
- Publication date
- 01/12/1994
- Field of study
Get PDFBruce Dowbiggin\u27s The Defense Never Rests (book review)
- Publication venue
- eRepository @ Seton Hall
- Publication date
- 01/12/1994
- Field of study
No full textReferences
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- 'Informa UK Limited'
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No full textIntroducing the CTA concept
- Publication venue
- Publication date
- 01/01/2013
- Field of study
No full textThe Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. © 2013 Elsevier B.V. All rights reserved
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
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- Adamo P. (Pio) d'
- Adan R. (R.)
- Alavere H. (Helene)
- Albrecht E. (Eva)
- Alexander G. (Graeme)
- Alfredsson L. (Lars)
- Amin N. (Najaf)
- Amin N. (Najaf)
- Anderson C.A. (Carl A)
- Ando T. (Tetsuya)
- Ang W.Q. (Wei)
- Antel J. (J.)
- Aspelund T. (T.)
- Aspelund T. (Thor)
- Atalay M. (Mustafa)
- Baker J.H. (Jessica H)
- Barrett J.C. (Jeffrey)
- Barroso I.E. (Inês)
- Beijsterveldt C.E.M. (Toos) van
- Bencko V. (Vladimir)
- Benke K. (K.)
- Berenson G. (Gerald)
- Bergen A.W. (Andrew)
- Bergen N. (N.)
- Bergmann S.M. (Sven)
- Berrettini W. (Wade)
- Berry D. (Diane)
- Bierut L.J. (L. J.)
- Bierut L.J. (Laura)
- Blackburn H. (Hannah)
- Boerwinkle E. (E.)
- Boerwinkle E.A. (Eric)
- Boni C. (Claudette)
- Boomsma D.I. (Dorret)
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- Boyd H.A. (H. A.)
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- Ophoff R.A. (Roel)
- Ouwehand W.H. (Willem)
- O’Toole J.K. (Julie K)
- Padyukov L. (L.)
- Padyukov L. (Leonid)
- Palmer C. (Cameron)
- Palotie A. (A.)
- Palotie A. (Aarno)
- Panoutsopoulou K. (K.)
- Pantel J. (Jacques)
- Papezova H. (Hana)
- Pararajasingham J. (Jennifer)
- Pare G. (Guillame)
- Parker A.N. (Alex)
- Peacock M. (M.)
- Peacock M. (Munro)
- Pearson E.R. (E. R.)
- Pedersen N.L. (Nancy)
- Peltonen L. (Leena Johanna)
- Pennell C.E. (Craig)
- Perry J.R. (J. R.)
- Pinto D. (Dalila)
- Pinto D. (Duane)
- Plump A.S. (A. S.)
- Polasek O. (Ozren)
- Porcu E. (Eleonora)
- Potter S.C. (Simon)
- Power C. (Christopher)
- Price T.S. (Thomas)
- Prokopenko I. (Inga)
- Rabionet R. (Raquel)
- Raevuori-Helkamaa A. (Anu)
- Rafnar T. (Thorunn)
- Raitakari O.T. (O. T.)
- Rajewski A. (Andrzej)
- Ramoz N. (Nicolas)
- Rayner N.W. (Nigel William)
- Reinvang I. (Ivar)
- Rice J.P. (John)
- Rich S.S. (Stephen)
- Ridker P.M. (Paul)
- Ring S.M. (Susan)
- Ripatti S. (Samuli)
- Ritchie G.R.S. (Graham R.S.)
- Rivadeneira Ramirez F. (Fernando)
- Rivadeneira F. (F.)
- Roberts M. (Marion)
- Rodriguez A. (A.)
- Rotondo A. (Alessandro)
- Rujescu D. (Dan)
- Rybakowski F. (Filip)
- Sala C. (Cinzia)
- Salem R.M. (Rany)
- Salomaa V. (Veikko)
- Sambrook J. (Jennifer)
- Sandford R. (Richard)
- Sanna S. (Serena)
- Santonastaso P. (Paolo)
- Saw S.M. (S. M.)
- Scherag A. (A.)
- Scherag A. (Andre)
- Scherer S.W. (Stephen W)
- Scherer S.W. (Stephen)
- Schlessinger D. (D.)
- Schmidt U. (Ulrike)
- Schosser A. (Alexandra)
- Schreiber S. (Stefan)
- Scuteri A. (A.)
- Scuteri A. (Angelo)
- Sebert S. (S.)
- Segrè A.V. (Ayellet)
- Sheerin N. (Neil)
- Siitonen N. (Niina)
- Simpkin D. (Douglas)
- Slachtova L. (Lenka)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Slof-Op’t Landt M.C.T. (Margarita C. T.)
- Slopien A. (Agnieszka)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Southam L. (Lorraine)
- Sovio U. (Ulla)
- Spector T.D. (Timothy)
- Srinivasan S.R. (Sathanur)
- Steen V.M. (Vidar)
- Stephens J. (Jonathan)
- Stolk L. (Lisette)
- Strachan D.P. (David)
- Streeten E.A. (Elizabeth)
- Strengman E. (Eric)
- Strober M. (Michael)
- Sulem P. (Patrick)
- Sullivan P.F. (Patrick)
- Sunyer J. (J.)
- Sunyer J. (Jordi)
- Szatkiewicz J.P. (Jin P)
- Szeszenia-Dabrowska N. (Neonila)
- Sørensen T.I.A. (Thorkild)
- Taal H.R. (Rob)
- Tachmazidou I. (Ioanna)
- Taico C. (Chrysecolla)
- Tammesoo M.L. (M. L.)
- Tenconi E. (Elena)
- Teo Y.Y. (Y. Y.)
- Teo Y.Y. (Yik Ying)
- Thiering E. (Elisabeth)
- Thornton L.M. (Laura)
- Thorsteinsdottir U. (Unnur)
- Tiesler C. (C.)
- Tikkanen E. (Emmi)
- Timpson N.J. (Nicholas)
- Toniolo D. (Daniela)
- Tortorella A. (Alfonso)
- Tozzi F. (Federica)
- Trace S.E. (Sara E)
- Treasure J. (Janet)
- Tryggvadottir L. (Laufey)
- Tschop M. (Matthias)
- Tschöp M.H. (M. H.)
- Tsitsika A. (Artemis)
- Tsitsika A. (Artemis)
- Tyrer J. (J.)
- Tziouvas K. (Konstantinos)
- Uda M. (M.)
- Uitterlinden A.G. (André)
- Ulivi S. (Shelia)
- Valcárcel B. (Beatriz)
- van Dam R.M. (R. M.)
- Vannberg F.O. (Frederik O)
- Versini A. (Audrey)
- Visser J.A. (Jenny)
- Volckmar A.-L. (A. L.)
- Vollenweider P. (Peter)
- Waeber G. (Gérard)
- Wagner G. (Gudrun)
- Wareham N.J. (Nick)
- Warrington M. (M.)
- Warrington N.M. (Nicole)
- Waterworth D. (Dawn)
- Weedon M.N. (Michael)
- White S.J. (Stefan)
- Whittaker P. (Pamela)
- Wichmann H.E. (Heinz Erich)
- Widen E.
- Widen E. (E.)
- Willemsen G.A.H.M. (Gonneke)
- Wilson J.F. (J. F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Woodside D.B. (D Blake)
- Wright A.F. (Alan)
- Yaghootkar H. (H.)
- Yilmaz Z. (Zeynep)
- Young L. (L.)
- Zeggini E. (Eleftheria)
- Zerwas S. (Stephanie)
- Zgaga L. (L.)
- Zhai G. (G.)
- Zhao J.H. (J. H.)
- Zhuang W.V. (W. V.)
- Zipfel S. (S.)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2017
- Field of study
No full textThe maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 × 10-5, Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 × 10-06/Pfemales: 3.45 × 10-07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation
