Library Cooperation and the Development of the North Carolina Information Network (NCIN): From the Great Depression Years to 1992

This article recounts the history of the development of library networks, computerization of library processes, and the uses of technology in libraries in North Carolina from the Great Depression to 1992

Genetic Diversity and Antimicrobial Susceptibility of Campylobacter jejuni Isolates Associated with Sheep Abortion in the United States and Great Britain

Campylobacter infection is a leading cause of ovine abortion worldwide. Historically, genetically diverse Campylobacter fetus and Campylobacter jejunistrains have been implicated in such infections, but since 2003 a highly pathogenic, tetracycline-resistant C. jejuni clone (named SA) has become the predominant cause of sheep abortions in the United States. Whether clone SA was present in earlier U.S. abortion isolates (before 2000) and is associated with sheep abortions outside the United States are unknown. Here, we analyzed 54 C. jejuniisolates collected from U.S. sheep abortions at different time periods and compared them with 42 C. jejuni isolates associated with sheep abortion during 2002 to 2008 in Great Britain, using multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and array-based comparative genomic hybridization (CGH). Although clone SA (ST-8) was present in the early U.S. isolates, it was not as tetracycline resistant (19% versus 100%) or predominant (66% versus 91%) as it was in the late U.S isolates. In contrast, C. jejuni isolates from Great Britain were genetically diverse, comprising 19 STs and lacking ST-8. PFGE and CGH analyses of representative strains further confirmed the population structure of the abortion isolates. Notably, the Great Britain isolates were essentially susceptible to most tested antibiotics, including tetracycline, while the late U.S. isolates were universally resistant to this antibiotic, which could be explained by the common use of tetracyclines for control of sheep abortions in the United States but not in Great Britain. These results suggest that the dominance of clone SA in sheep abortions is unique to the United States, and the use of tetracyclines may have facilitated selection of this highly pathogenic clone

Gaining Insights About Water: The Value of Surveys in First Nations Communities to Inform Water Governance

Knowledge of how water is perceived, used and managed in a community is critical to the endeavour of water governance. Surveys of individuals residing in a community offer a valuable avenue to gain information about several of these aspects of water. This paper draws upon experiences in three First Nation communities to explore the values of surveys to illuminate water issues and inform water decision-making. Findings from experiences with surveys in Six Nations of the Grand River, Mississaugas of the New Credit, and Oneida First Nation of the Thames reveal rich information about how surveys can provide insights about: the connection of individuals to the land, water and their community; reasons for valuing water; perceptions of water quality and issues surrounding water-related advisories; and, degree of satisfaction with water management and governance at different scales. Community partners reflected upon the findings of the survey for their community. Dialogue was then broadened across the cases as the partners offer benefits and challenges associated with the survey. Community surveys offer an important tool in the resource managers’ toolbox to understand social perceptions of water and provide valuable insights that may assist in improving its governance

Contemporary Water Governance: Navigating Crisis Response and Institutional Constraints through Pragmatism

Water has often been the source of crises and their frequency will intensify due to climate change impacts. The Niagara River Watershed provides an ideal case to study water crises as it is an international transboundary system (Canada-United States) and has both historical and current challenges associated with water quantity and quality, which resonates broadly in water basins throughout the world. The aim of this study was to understand how stakeholders perceive ecosystems and the relationship with preferences for governance approaches in the context of water governance. An online survey instrument was employed to assess perceptions of the system in terms of resilience (engineering, ecological, social-ecological, or epistemic), preferences for governance approaches (state, citizen, market, and hybrid forms), and the most pressing issues in the watershed. Responses showed that, despite demographic differences and adherence to different resilience perspectives, support was strongest for governance approaches that focused on state or state-citizen hybrid forms. The validity of the resilience typology as a grouping variable is discussed. The roles of institutional constraints, pragmatism in governance approach preferences, and the influence of multiple crises are explored in relation to the context of the study site, as well as to water governance scholarship more broadly.Funding for this work, as part of the Climate Change Adaptation and Water Governance (CADWAGO) project, from Riksbankens Jubileumsfond, the Volkswagen Stiftung and Compagnia di San Paolo through the Europe and Global Challenges programme.https://www.mdpi.com/2073-4441/8/6/22

Ecosystem Perceptions in Flood Prone Areas: A Typology and Its Relationship to Preferences for Governance

A shift appears to be occurring in thinking about flooding, from a resistance-based approach to one of resilience. Accordingly, how stakeholders in flood-prone regions perceive the system and its governance are salient questions. This study queried stakeholders’ internal representations of ecosystems (resistance- or resilience-based), preferences for governance actors and mechanisms for flooding, and the relationship between them in five different regions of the world. The influence of personal experience on these variables was also assessed. Most respondents aligned themselves with a resilience-based approach in relation to system connectedness and response to disturbance; however, respondents were almost evenly split between resistance- and resilience-based approaches when considering system management. Responses generally were considered to hold for other disturbances as well. There was no clear relationship between internal representations and preferences for governance actors or mechanisms. Respondents generally favoured actor combinations that included governments and mechanism combinations that included regulations and policies. Those who had personal experience with flooding tended to align themselves with a resilience-based internal representation of system management, but personal experience showed no clear relationship with governance preferences. The findings support an evolutionary perspective of flood management where emerging paradigms enhance preceding ones, and prompt a critical discussion about the universality of resilience as a framing construct.Financial support for the CADWAGO project from Riksbankens Jubileumsfond, the Volkswagen Stiftung and Compagnia di San Paolo through the Europe and Global Challenges programme, as well as the Swedish Civil Contingencies Agency (MSB).https://www.mdpi.com/2073-4441/8/5/19

Probing the relationship between ecosystem perceptions and approaches to environmental governance: an exploratory content analysis of seven water dilemmas

Addressing wicked ‘water dilemmas’ requires an understanding of the context within which they are embedded. This study explored perceptions of the ecosystem in terms of resilience and the governance approaches employed through a content analysis of documents from seven case studies across the globe. Analytical constructs developed for resilience and governance approaches guided the exploration. Multiple resilience types were present in documents for each case, but few patterns emerged across cases. Governance approaches were strongly focused on state approaches in most cases. A relationship between resilience type and governance approach was not clear; however, a pattern emerged between the presence of the social–ecological resilience type and non-state-centred governance forms. The type of author (government, non-government) or the type of document (research and advisory, descriptive) were not found to mediate the findings as resilience framings varied considerably and state governance approaches were emphasised throughout. As the findings stand in contrast to contemporary scholarship on understanding ecosystems and environmental governance they raise important issues to which individuals must be cognizant when accessing documents for guidance. They also open avenues for future investigation of water dilemmas at the nexus of theory, policy and practice."Funding for this work, as part of the CADWAGO project, was provided by Riksbankens Jubileumsfond, the Volkswagen Stiftung and Compagnia di San Paolo through the Europe and Global Challenges programme."https://www.tandfonline.com/doi/full/10.1080/21693293.2016.120290

The Chandra Source Catalog

The Chandra Source Catalog (CSC) is a general purpose virtual X-ray astrophysics facility that provides access to a carefully selected set of generally useful quantities for individual X-ray sources, and is designed to satisfy the needs of a broad-based group of scientists, including those who may be less familiar with astronomical data analysis in the X-ray regime. The first release of the CSC includes information about 94,676 distinct X-ray sources detected in a subset of public ACIS imaging observations from roughly the first eight years of the Chandra mission. This release of the catalog includes point and compact sources with observed spatial extents <~ 30''. The catalog (1) provides access to the best estimates of the X-ray source properties for detected sources, with good scientific fidelity, and directly supports scientific analysis using the individual source data; (2) facilitates analysis of a wide range of statistical properties for classes of X-ray sources; and (3) provides efficient access to calibrated observational data and ancillary data products for individual X-ray sources, so that users can perform detailed further analysis using existing tools. The catalog includes real X-ray sources detected with flux estimates that are at least 3 times their estimated 1 sigma uncertainties in at least one energy band, while maintaining the number of spurious sources at a level of <~ 1 false source per field for a 100 ks observation. For each detected source, the CSC provides commonly tabulated quantities, including source position, extent, multi-band fluxes, hardness ratios, and variability statistics, derived from the observations in which the source is detected. In addition to these traditional catalog elements, for each X-ray source the CSC includes an extensive set of file-based data products that can be manipulated interactively.Comment: To appear in The Astrophysical Journal Supplement Series, 53 pages, 27 figure

Deweyan tools for inquiry and the epistemological context of critical pedagogy

This article develops the notion of resistance as articulated in the literature of critical pedagogy as being both culturally sponsored and cognitively manifested. To do so, the authors draw upon John Dewey\u27s conception of tools for inquiry. Dewey provides a way to conceptualize student resistance not as a form of willful disputation, but instead as a function of socialization into cultural models of thought that actively truncate inquiry. In other words, resistance can be construed as the cognitive and emotive dimensions of the ongoing failure of institutions to provide ideas that help individuals both recognize social problems and imagine possible solutions. Focusing on Dewey\u27s epistemological framework, specifically tools for inquiry, provides a way to grasp this problem. It also affords some innovative solutions; for instance, it helps conceive of possible links between the regular curriculum and the study of specific social justice issues, a relationship that is often under-examined. The aims of critical pedagogy depend upon students developing dexterity with the conceptual tools they use to make meaning of the evidence they confront; these are background skills that the regular curriculum can be made to serve even outside social justice-focused curricula. Furthermore, the article concludes that because such inquiry involves the exploration and potential revision of students\u27 world-ordering beliefs, developing flexibility in how one thinks may be better achieved within academic subjects and topics that are not so intimately connected to students\u27 current social lives, especially where students may be directly implicated

Statistical Characterization of the Chandra Source Catalog

The first release of the Chandra Source Catalog (CSC) contains ~95,000 X-ray sources in a total area of ~0.75% of the entire sky, using data from ~3,900 separate ACIS observations of a multitude of different types of X-ray sources. In order to maximize the scientific benefit of such a large, heterogeneous data-set, careful characterization of the statistical properties of the catalog, i.e., completeness, sensitivity, false source rate, and accuracy of source properties, is required. Characterization efforts of other, large Chandra catalogs, such as the ChaMP Point Source Catalog (Kim et al. 2007) or the 2 Mega-second Deep Field Surveys (Alexander et al. 2003), while informative, cannot serve this purpose, since the CSC analysis procedures are significantly different and the range of allowable data is much less restrictive. We describe here the characterization process for the CSC. This process includes both a comparison of real CSC results with those of other, deeper Chandra catalogs of the same targets and extensive simulations of blank-sky and point source populations.Comment: To be published in the Astrophysical Journal Supplement Series (Fig. 52 replaced with a version which astro-ph can convert to PDF without issues.

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart

Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood. When functioning normally, mature heart valves prevent intracardiac retrograde blood flow; before valves develop, there is considerable regurgitation, resulting in reversing (or oscillatory) flows between the atrium and ventricle. As reversing flows are particularly strong stimuli to endothelial cells in culture, an attractive hypothesis is that heart valves form as a developmental response to retrograde blood flows through the maturing heart. Here, we exploit the relationship between oscillatory flow and heart rate to manipulate the amount of retrograde flow in the atrioventricular (AV) canal before and during valvulogenesis, and find that this leads to arrested valve growth. Using this manipulation, we determined that klf2a is normally expressed in the valve precursors in response to reversing flows, and is dramatically reduced by treatments that decrease such flows. Experimentally knocking down the expression of this shear-responsive gene with morpholine antisense oligonucleotides (MOs) results in dysfunctional valves. Thus, klf2a expression appears to be necessary for normal valve formation. This, together with its dependence on intracardiac hemodynamic forces, makes klf2a expression an early and reliable indicator of proper valve development. Together, these results demonstrate a critical role for reversing flows during valvulogenesis and show how relatively subtle perturbations of normal hemodynamic patterns can lead to both major alterations in gene expression and severe valve dysgenesis