Effect of PPD stimulation on mitochondrial and cell membrane damage in mononuclear phagocytes from household contacts of smear-positive patients in Colombia.

<p>The level of mitochondrial damage was calculated as the difference between the percentage of PPD stimulated cells minus the percentage of non-stimulated cells for mitochondrial damage and cell membrane damage.</p

ROC curves showing the predictive capacity of the level of mitochondrial damage to predict active TB development in household contacts of smear-positive patients with or without BCG vaccination.

<p>The gray area shows the confidence interval of AUC (Area Under Curve),Se (Sensitivity), Sp (Specificity).</p

Distribution of the percentage of monocytes with mitochondrial damage and membrane damage in peripheral blood mononuclear cells (PBMC) cultures from household contacts stimulated and non-stimulated with PPD.

<p>The inset shows the Median (Me) of the percentage of monocytes with mitochondrial (Panels A and C) and cell membrane damage (Panels B and D).Stimulated and non-stimulated cultures were compared using the Wilcoxon test.</p

Risk factors associated with the induction of monocytes’ mitochondrial and membrane damage in response to PPD, in mononuclear phagocytes obtained from household contacts of smear-positive TB patients in Colombia.

<p>Risk factors associated with the induction of monocytes’ mitochondrial and membrane damage in response to PPD, in mononuclear phagocytes obtained from household contacts of smear-positive TB patients in Colombia.</p

Risk factors associated with TB incidence according to the presence of BCG scar in household contacts of smear-positive TB patients in Colombia.

<p>Risk factors associated with TB incidence according to the presence of BCG scar in household contacts of smear-positive TB patients in Colombia.</p

Effect of the induction of mitochondrial monocyte damage and BCG vaccination on the probability of developing tuberculosis in household contacts (HHC) of smear-positive TB patients.

<p>The dotted line shows the probability of the HHC that did not have mitochondrial damage (MD -); the black line shows the probability of HHC that did have mitochondrial damage (MD+). Household contacts of smear-positive patients were followed up for two years to detect development of active TB disease. Probabilities were calculated by Kaplan-Meier and compared by Log-Rank test. HR: Hazard Ratio.</p

Incidence of tuberculosis according to the level of mitochondrial damage in household contacts of smear-positive patients with or without BCG vaccination.

<p>The level of mitochondrial damage was categorized by quartiles. The trend in decreasing incidence of active TB was assessed with chi square test for trend (chi square test for trend = 8.66, p = 0.003).</p

TB incidence and non-adjusted Hazard Ratio (HR) that influences development of TB according to various factors related to households of smear-positive patients in Colombia.

<p>TB incidence and non-adjusted Hazard Ratio (HR) that influences development of TB according to various factors related to households of smear-positive patients in Colombia.</p

Flowchart of inmates included in the study.

<p>Flowchart of inmates included in the study.</p

Time to sputum smear and culture conversion after anti-TB treatment initiation.

<p>Time to sputum smear and culture conversion after anti-TB treatment initiation.</p