817 research outputs found
Analysis of Imperfections in Practical Continuous-Variable Quantum Key Distribution
As quantum key distribution becomes a mature technology, it appears clearly
that some assumptions made in the security proofs cannot be justified in
practical implementations. This might open the door to possible side-channel
attacks. We examine several discrepancies between theoretical models and
experimental setups in the case of continuous-variable quantum key
distribution. We study in particular the impact of an imperfect modulation on
the security of Gaussian protocols and show that approximating the theoretical
Gaussian modulation with a discrete one is sufficient in practice. We also
address the issue of properly calibrating the detection setup, and in
particular the value of the shot noise. Finally, we consider the influence of
phase noise in the preparation stage of the protocol and argue that taking this
noise into account can improve the secret key rate because this source of noise
is not controlled by the eavesdropper.Comment: 4 figure
Exposure to antibiotics and neurodevelopmental disorders: could probiotics modulate the gut–brain axis?
In order to develop properly, the brain requires the intricate interconnection of genetic factors and pre-and postnatal environmental events. The gut–brain axis has recently raised considerable interest for its involvement in regulating the development and functioning of the brain. Consequently, alterations in the gut microbiota composition, due to antibiotic administration, could favor the onset of neurodevelopmental disorders. Literature data suggest that the modulation of gut microbiota is often altered in individuals affected by neurodevelopmental disorders. It has been shown in animal studies that metabolites released by an imbalanced gut–brain axis, leads to alterations in brain function and deficits in social behavior. Here, we report the potential effects of antibiotic administration, before and after birth, in relation to the risk of developing neurodevelopmental disorders. We also review the potential role of probiotics in treating gastrointestinal disorders associated with gut dysbiosis after antibiotic administration, and their possible effect in ameliorating neurodevelopmental disorder symptoms
Etiology and management of pediatric intestinal failure: Focus on the non-digestive causes
Background: Intestinal failure (IF) is defined as reduction in functioning gut mass below the minimal amount necessary for adequate digestion and absorption. In most cases, IF results from intrinsic diseases of the gastrointestinal tract (digestive IF) (DIF); few cases arise from digestive vascular components, gut annexed (liver and pancreas) and extra-digestive organs or from systemic diseases (non-digestive IF) (NDIF). The present review revised etiology and treatments of DIF and NDIF, with special focus on the pathophysiological mechanisms, whereby NDIF develops. Methods: We performed a comprehensive search of published literature from January 2010 to the present by selecting the following search strings: “intestinal failure” OR “home parenteral nutrition” OR “short bowel syndrome” OR “chronic pseudo-obstruction” OR “chronic intestinal pseudo-obstruction” OR “autoimmune enteropathy” OR “long-term parenteral nutrition”. Results: We collected overall 1656 patients with well-documented etiology of IF: 1419 with DIF (86%) and 237 with NDIF (14%), 55% males and 45% females. Among DIF cases, 66% had SBS and among NDIF cases 90% had malabsorption/maldigestion. Conclusions: The improved availability of diagnostic and therapeutic tools has increased prevalence and life expectancy of rare and severe diseases responsible for IF. The present review greatly expands the spectrum of knowledge on the pathophysiological mechanisms through which the diseases not strictly affecting the intestine can cause IF. In view of the rarity of the majority of pediatric IF diseases, the development of IF Registries is strongly required; in fact, through information flow within the network, the Registries could improve IF knowledge and management
Improvement of continuous-variable quantum key distribution systems by using optical preamplifiers
Continuous-variable quantum key distribution protocols, based on Gaussian
modulation of the quadratures of coherent states, have been implemented in
recent experiments. A present limitation of such systems is the finite
efficiency of the detectors, which can in principle be compensated for by the
use of classical optical preamplifiers. Here we study this possibility in
detail, by deriving the modified secret key generation rates when an optical
parametric amplifier is placed at the output of the quantum channel. After
presenting a general set of security proofs, we show that the use of
preamplifiers does compensate for all the imperfections of the detectors when
the amplifier is optimal in terms of gain and noise. Imperfect amplifiers can
also enhance the system performance, under conditions which are generally
satisfied in practice.Comment: 11 pages, 7 figures, submitted to J. Phys. B (special issue on Few
Atoms Optics
Experimental verification of multipartite entanglement in quantum networks
Multipartite entangled states are a fundamental resource for a wide range of
quantum information processing tasks. In particular, in quantum networks it is
essential for the parties involved to be able to verify if entanglement is
present before they carry out a given distributed task. Here we design and
experimentally demonstrate a protocol that allows any party in a network to
check if a source is distributing a genuinely multipartite entangled state,
even in the presence of untrusted parties. The protocol remains secure against
dishonest behaviour of the source and other parties, including the use of
system imperfections to their advantage. We demonstrate the verification
protocol in a three- and four-party setting using polarization-entangled
photons, highlighting its potential for realistic photonic quantum
communication and networking applications.Comment: 8 pages, 4 figure
Plasma and red blood cell pufas in home parenteral nutrition paediatric patients—effects of lipid emulsions
Background: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). Aim of the study: to assess glycerophosfolipid polyunsaturated fatty acids (PUFA) levels on plasma and red blood cell (RBC) membrane of children on long term PN with composite LE containing fish oil (SMOF), and to compare it with a group receiving olive oil LE (Clinoleic®) and to the reference range for age, previously determined on a group of healthy children. Results: A total of 38 patients were enrolled, median age 5.56 (0.9–21.86) years, 15 receiving Clinoleic®, 23 receiving SMOF. Patients on SMOF showed significantly higher levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower levels of arachidonic acid (ARA) and Mead acid (MEAD)/ARA ratio in plasma and RBC compared with patients on Clinoleic® and with healthy children. Triene:tetraene (T:T) ratio of both groups of patients did not differ from that of healthy children-median plasma (MEAD/ARA: 0.01, interquartile rage (IQR) 0.01, p = 0.61 and 0.02, IQR 0.02, p = 0.6 in SMOF and Clinoleic® patients, respectively), and was considerably lower than Holman index (>0.21). SMOF patients showed no statistically significant differences in growth parameters compared with Clinoleic® patients. Patients of both groups showed stiffness class F0-F1 of liver stiffness measure (LSM) 5.6 (IQR 0.85) in SMOF patients and 5.3 (IQR 0.90) in Clinoleic® patients, p = 0.58), indicating absence of liver fibrosis. Conclusions: Fatty acids, measured as concentrations (mg/L), revealed specific PUFA profile of PN patients and could be an accurate method to evaluate nutritional status and eventually to detect essential fatty acid deficiency (EFAD). SMOF patients showed significantly higher EPA, DHA and lower ARA concentrations compared to Clinoleic® patients. Both LEs showed similar hepatic evolution and growth
Field test of a continuous-variable quantum key distribution prototype
We have designed and realized a prototype that implements a
continuous-variable quantum key distribution protocol based on coherent states
and reverse reconciliation. The system uses time and polarization multiplexing
for optimal transmission and detection of the signal and phase reference, and
employs sophisticated error-correction codes for reconciliation. The security
of the system is guaranteed against general coherent eavesdropping attacks. The
performance of the prototype was tested over preinstalled optical fibres as
part of a quantum cryptography network combining different quantum key
distribution technologies. The stable and automatic operation of the prototype
over 57 hours yielded an average secret key distribution rate of 8 kbit/s over
a 3 dB loss optical fibre, including the key extraction process and all quantum
and classical communication. This system is therefore ideal for securing
communications in metropolitan size networks with high speed requirements.Comment: 15 pages, 6 figures, submitted to New Journal of Physics (Special
issue on Quantum Cryptography
Post-processing with linear optics for improving the quality of single-photon sources
Published versio
- …