Barotropic Vortex Pairs on a Rotating Sphere

Using a barotropic model in spherical geometry, we construct new solutions for steadily travelling vortex pairs and study their stability properties. We consider pairs composed of both point and finite-area vortices, and we represent the rotating background with a set of zonal strips of uniform vorticity. After constructing the solution for a single point-vortex pair, we embed it in a rotating background, and determine the equilibrium configurations that travel at constant speed without changing shape. For equilibrium solutions, we find that the stability depends on the relative strength (which may be positive or negative) of the vortex pair to the rotating background: eastward-travelling pairs are always stable, while westward-travelling pairs are unstable when their speeds approach that of the linear Rossby–Haurwitz waves. This finding also applies (with minor differences) to the case when the vortices are of finite area; in that case we find that, in addition to the point-vortex-like instabilities, the rotating background excites some finite-area instabilities for vortex pairs that would otherwise be stable. As for practical applications to blocking events, for which the slow westward pairs are relevant, our results indicate that free barotropic solutions are highly unstable, and thus suggest that forcing mechanisms must play an important role in maintaining atmospheric blocking events

A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis

The tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG(4), is a novel amyloid-binding small molecule that can penetrate the blood–brain barrier and protect cells from Aβ-induced toxicity. However, the effects of Aβ-targeting molecules on other cellular processes, including those that modulate synaptic plasticity, remain unknown. We report here that BTA-EG(4) decreases Aβ levels, alters cell surface expression of amyloid precursor protein (APP), and improves memory in wild-type mice. Interestingly, the BTA-EG(4)-mediated behavioral improvement is not correlated with LTP, but with increased spinogenesis. The higher dendritic spine density reflects an increase in the number of functional synapses as determined by increased miniature EPSC (mEPSC) frequency without changes in presynaptic parameters or postsynaptic mEPSC amplitude. Additionally, BTA-EG(4) requires APP to regulate dendritic spine density through a Ras signaling-dependent mechanism. Thus, BTA-EG(4) may provide broad therapeutic benefits for improving neuronal and cognitive function, and may have implications in neurodegenerative disease therapy

Population genomic response to geographic gradients by widespread and endemic fishes of the Arabian Peninsula

Genetic structure within marine species may be driven by local adaptation to their environment, or alternatively by historical processes, such as geographic isolation. The gulfs and seas bordering the Arabian Peninsula offer an ideal setting to examine connectivity patterns in coral reef fishes with respect to environmental gradients and vicariance. The Red Sea is characterized by a unique marine fauna, historical periods of desiccation and isolation, as well as environmental gradients in salinity, temperature, and primary productivity that vary both by latitude and by season. The adjacent Arabian Sea is characterized by a sharper environmental gradient, ranging from extensive coral cover and warm temperatures in the southwest, to sparse coral cover, cooler temperatures, and seasonal upwelling in the northeast. Reef fish, however, are not confined to these seas, with some Red Sea fishes extending varying distances into the northern Arabian Sea, while their pelagic larvae are presumably capable of much greater dispersal. These species must therefore cope with a diversity of conditions that invoke the possibility of steep clines in natural selection. Here, we test for genetic structure in two widespread reef fish species (a butterflyfish and surgeonfish) and eight range-restricted butterflyfishes across the Red Sea and Arabian Sea using genome-wide single nucleotide polymorphisms. We performed multiple matrix regression with randomization analyses on genetic distances for all species, as well as reconstructed scenarios for population subdivision in the species with signatures of isolation. We found that (a) widespread species displayed more genetic subdivision than regional endemics and (b) this genetic structure was not correlated with contemporary environmental parameters but instead may reflect historical events. We propose that the endemic species may be adapted to a diversity of local conditions, but the widespread species are instead subject to ecological filtering where different combinations of genotypes persist under divergent ecological regimes