15 research outputs found
e E ect of Lactobacillus reuteri Supplementation in Adults with Chronic Functional Constipation: a Randomized, Double-Blind, Placebo-Controlled Trial*
Su2124 Diabetes and Gastrointestinal Disorders: The Effect of Intestinal Methane Production on Glycemic Control
Su1941 High Level of Methanogenic Flora in Patients Affected by Poorly Controlled Type I Diabetes
Sa1344 Study of Gastric Emptying and Digestive Function With 13C Octanoic Acid Breath Test in Non Dyspeptic Healthy Volunteers
Tu1060 Role of CagA-Positive Strains of H. pylori in Acute Myocardial Infarction With ST-Segment Elevation
Real-time diagnosis of H. pylori infection during endoscopy: Accuracy of an innovative tool (EndoFaster)
Background: EndoFaster is novel device able to perform real-time ammonium measurement in gastric juice allowing H. pylori diagnosis during endoscopy. This large study aimed to validate the accuracy of EndoFaster for real-time H. pylori detection. Methods: Consecutive patients who underwent upper endoscopy in two centres were prospectively enrolled. During endoscopy, 4 ml of gastric juice were aspirated to perform automatic analysis by EndoFaster within 90 seconds, and H. pylori was considered present (>62 ppm/ml) or absent ( 6462 ppm/ml). Accuracy was measured by using histology as gold standard, and 13C-urea breath test (UBT) in discordant cases. Accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) were calculated. Results: Overall, 189 patients were enrolled, but in seven (3.4%) the aspirated gastric juice amount was insufficient to perform the test. The accuracy, sensitivity, specificity, PPV, and NPV were 87.4%, 90.3%, 85.5%, 80.2%, 93.1%, respectively, and 92.6%, 97.1%, 89.7%, 85.9%, 98.0%, respectively, when H. pylori status was reclassified according to the UBT result in discordant cases. Conclusions: This study found a high accuracy/feasibility of EndoFaster for real-time H. pylori diagnosis. Use of EndoFaster may allow selecting those patients in whom routine gastric biopsies could be avoided