Anthropogenic sinkholes in the Marsala area (western Sicily) linked to underground quarries

Marsala territory (western Sicily) is characterized by the presence of a Lower Pleistocene (Calabrian) calcarenite succession (Marsala Calcarenite Fm). It can be divided into three lithofacies that show the regressive evolution of the depositional system: a) coarse to fine yellow bio- and lithoclastic calcarenites, b) sands, and c) gray sandy clays. At least 80 m-thick, this succession gently dips (5-10) towards the south and the south-west. At some locations the Marsala Calcarenite is covered by Middle and Upper Pleistocene marine terraced deposits. Since the Roman period, due to the great abundance of calcarenite rocks, and to the facility of extraction, the Marsala area has been characterized by a high number of quarries for the extraction of this building materials. Many of them were excavated underground, at depth varying from a few meters to about 25 m, and are arranged in one or two levels, following the galleries and pillars excavation technique. With time, the underground quarries have been progressively abandoned for the decay of the physical and mechanical properties of the calcarenite rock mass, the interaction with the groundwater, the high costs of extraction, and the dangers and difficulties encountered in working underground. Since the 1960’s the quarries have been affected by instability processes, visible through collapses and deformations of vaults and pillars. These phenomena often propagate upward reaching the topographic surface and forming sinkholes which affect and severely damage the built-up area. In particular, two case studies of sinkholes related to different underground quarries will be analyzed in this paper. The aim is to provide a description of the most significant processes and factors responsible of the instability processes based on field surveys, as well as to understand the generation mechanisms of these anthropogenic sinkholes by means of numerical modeling, based on rock laboratory testing data, that represents in these cases a remarkable tool for the investigation of the cause-effect relationships, as already performed in other areas of Italy

The predictive role of pelvic magnetic resonance in the follow up of spontaneous or induced puberty in turner syndrome

Puberty is a critical age for patients with Turner syndrome (TS): infertility is reported to be linked to karyotype and spontaneous puberty and menarche occur in approximately 30% of patients, especially in mosaicism. However, it is not always predictable considering hormonal pattern and pelvic transabdominal ultrasound scan (US). The aim of the study is to compare the accuracy of Magnetic Resonance Imaging (MRI) and US to evaluate uterine and gonads volume, to visualize the presence of follicles and to predict spontaneous puberty and menarche in girls with TS. In a retrospective study, we evaluated 19 TS patients (age: 9-16 years), who underwent transabdominal pelvic US and pelvic MRI as required by parents. We correlated pelvic imaging with karyotype, hormonal data and pubertal outcome, and we compared US resolution to MRI. MRI revealed a higher accuracy in the study of uterus and ovaries, and permitted to measure ovaries not visualized by US. Ovarian volume, the presence of follicles and the occurrence of spontaneous puberty were not related to the karyotype; spontaneous puberty started in one patient with a karyotype 45,X and in two patients with mosaicism (45,X/46,XX; 47,XXX/45, X). Ovarian follicles were relieved by MRI in patients with a spontaneous menarche and the persistence of menstrual cycles correlated with an ovarian volume corresponding to Tanner stage 3-4. We stress the role of MRI in the follow-up of TS adolescents, guide in the choice of the timing of treatment

Extremely fast Holocene coastal landscape evolution in the Kachchh Upland (NW India): Clues from a multidisciplinary review

The coastal landscape of the Kachchh Upland (KU) region (NW-India) changed over the last few thousand years from a shallow marine gulf to a salty desert (1-4 meters asl). In this area, bordered to the south by the Northern Hill Range (NHR), the tectonic-climatic interaction triggered the sea level fall from +2/4 m circa (6000-2000 BP) to zero. An ancient river pattern deposited a tidally regulated delta area during the sea level fall that stopped 2000-3000 years ago due to tectonic activity and a dry climate. Deltaic-alluvial fans (DAF) in front of the NHR suggest that the KU's tectonic activity led to fast landscape evolution. We explored such drastic changes by integrating scientific information from a multidisciplinary literature review, identifying terraces and DAFs, and inferring faults through landform recognition, quantitative morphometry, and field surveys. Our interpretation, summarized in a map, provides new information on active processes along the NHR

PO-0752: Outcome of prostate cancer patients treated with 3DCRT: impact of rectal/bladder preparation

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Cutaneous metastasis from colorectal cancer: Making light on an unusual and misdiagnosed event

Cutaneous metastasis from solid tumors is a rare event and usually represents a late occurrence in the natural history of an advanced visceral malignancy. Rarely, cutaneous metastasis has been described in colorectal cancer patients. The most frequent cutaneous site of colorectal metastasis is the surgical scar in the abdomen following the removal of the primary malignancy, followed by the extremities, perineum, head, neck, and penis. Metastases to the thigh and back of the trunk are anecdotical. Dermatological diagnosis of cutaneous metastasis can be quite complex, especially in unusual sites, such as in the facial skin or thorax and in cases of single cutaneous lesions since metastasis from colorectal cancer is not usually the first clinical hypothesis, leading to misdiagnosis. To date, due to the rarity of cutaneous metastasis from colorectal cancer, little evidence, most of which is based on case reports and very small case series, is currently available. Therefore, a better understanding of the clinic-pathological characteristics of this unusual metastatic site represents an unmet clinical need. We present a large series of 29 cutaneous metastases from colorectal cancer with particular concerns regarding anatomic localization and the time of onset with respect to primitive colorectal cancer and visceral metastases

Aerosol-Assisted CVD-Grown PdO Nanoparticle-Decorated Tungsten Oxide Nanoneedles Extremely Sensitive and Selective to Hydrogen

We report for the first time the successful synthesis of palladium (Pd) nanoparticle (NP)-decorated tungsten trioxide (WO3) nanoneedles (NNs) via a two-step aerosol-assisted chemical vapor deposition approach. Morphological, structural, and elemental composition analysis revealed that a Pd(acac)2 precursor was very suitable to decorate WO3 NNs with uniform and well-dispersed PdO NPs. Gas-sensing results revealed that decoration with PdO NPs led to an ultrasensitive and selective hydrogen (H2) gas sensor (sensor response peaks at 1670 at 500 ppm of H2) with low operating temperature (150 °C). The response of decorated NNs is 755 times higher than that of bare WO3 NNs. Additionally, at a temperature near that of the ambient temperature (50 °C), the response of this sensor toward the same concentration of H2 was 23, which is higher than that of some promising sensors reported in the literature. Finally, humidity measurements showed that PdO/WO3 sensors displayed low-cross-sensitivity toward water vapor, compared to bare WO3 sensors. The addition of PdO NPs helps to minimize the effect of ambient humidity on the sensor response

Stopping power of helium gas for ^9Be ions from 2 to 31 MeV

Abstract The stopping power of helium gas for 9Be ions from 2 to 31 MeV is experimentally determined using an indirect method. The residual energy of the 9Be beam as a function of the gas thickness is measured and the stopping power determined by differentiating the thickness–energy curve. The results are compared with predictions of the semi-empirical codes SRIM-2003 and MSTAR. Our data are in better agreement with the MSTAR calculations. The elastic scattering excitation function for the system 9Be + α, extracted using the thick target technique and our stopping power data, is in excellent agreement with the ones measured directly confirming the quality of our data

Impact of Glycemic and Blood Pressure Variability on Surrogate Measures of Cardiovascular Outcomes in Type 2 Diabetic Patients

OBJECTIVE—The effect of glycemic variability (GV) on cardiovascular risk has not been fully clarified in type 2 diabetes. We evaluated the effect of GV, blood pressure (BP), and oxidative stress on intima-media thickness (IMT), left ventricular mass index (LVMI), flow-mediated dilation (FMD), and sympathovagal balance (low frequency [LF]/high frequency [HF] ratio) in 26 type 2 diabetic patients (diabetes duration 4.41 6 4.81 years; HbA1c 6.70 6 1.25%) receiving diet and/or metformin treatment, with no hypotensive treatment or complications. RESEARCH DESIGN AND METHODS—Continuous glucose monitoring (CGM) data were used to calculate mean amplitude of glycemic excursion (MAGE), continuous overall net glycemic action (CONGA)-2, mean blood glucose (MBG), mean postprandial glucose excursion (MPPGE), and incremental area under the curve (IAUC). Blood pressure (BP), circadian rhythm, and urinary 15-F2t-isoprostane (8-iso-prostaglandin F2a [PGF2a]) were also evaluated. Subjects were divided into dipper (D) and nondipper (ND) groups according to DBP. RESULTS—IMT and LVMIwere increased inNDversusD(0.7760.08 vs. 0.6860.13 [P=0.04] and 67 6 14 vs. 55 6 11 [P = 0.03], respectively). MBG, MAGE, and IAUC were significantly associated with LF/HF ratio at night (r = 0.50, P = 0.01; r = 0.40, P = 0.04; r = 0.41, P = 0.04, respectively), MPPGE was negatively associated with FMD (r =20.45, P = 0.02), andCONGA-2was positively associatedwith LVMI (r=0.55, P=0.006).TheDsystolic BP was negatively associated with IMT (r =20.43, P = 0.03) andwith LVMI (r =20.52, P = 0.01). Urinary 8-iso-PGF2a was positively associated with LVMI (r = 0.68 P , 0.001). CONCLUSIONS—An impaired GV and BP variability is associated with endothelial and cardiovascular damage in short-term diabetic patients with optimal metabolic control. Oxidative stress is the only independent predictor of increased LV mass and correlates with glucose and BP variability