Passato interattivo. Esempi di design contro-egemonico nei videogiochi storici

Lo scopo della presente ricerca è duplice. Il primo è che intende dimostrare la varietà di generi e meccaniche utilizzati nei videogiochi storici contro-egemonici per portare avanti le loro argomentazioni, in opposizione alla standardizzazione di generi e meccaniche esistente nei videogiochi storici egemonici. Il secondo è che intende mostrare come una stessa meccanica, implementata in due giochi diversi, possa essere usata per simulare concetti anche molto differenti, in alcuni casi opposti. In poche parole, una sorta di versatilità discorsiva delle meccaniche, che quindi devono essere studiate olisticamente per poterne determinare il ruolo e la funzione retorica

Capillary leak leading to shock in Kawasaki disease without myocardial dysfunction

Kawasaki disease is an acute vasculitis of childhood. Its clinical presentation is well known, and coronary artery aneurysms are classical complications. Shock and pleural or pericardiac effusion are rare presentations of the disease. In intensive care units, the disease may be mistaken for septic shock or toxic shock syndrome. Owing to the fact that immunoglobulin therapy improves the course of the disease, especially if given early, and thus the diagnosis should not be delaye

Derailment detection and data collection in freight trains, based on a wireless sensor network

We report the development of a network of wireless ultralow-power sensors to be deployed on freight railway cars, with the main purpose of detecting derailment events and alerting the engineer in the cab of the leading locomotive. Because no power bus is available on freight cars, we plan to rely on energy scavenging from vibrations; therefore, minimization of the power consumption has been one of our main priorities. We have, therefore, focused on ultralow-power hardware and strived to reduce the time intervals during which it is in active mode, achieving an average power consumption of ~0.5 mW with an active cycle of ~20 ms every 2 s. We discuss the overall concept that we propose, including the self-initialization protocol and the communication strategy that we have developed, and present the results of measurements on a prototype network that we have implemented

In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks

We describe an innovative experimental and computational approach to control the expression of a protein in a population of yeast cells. We designed a simple control algorithm to automatically regulate the administration of inducer molecules to the cells by comparing the actual protein expression level in the cell population with the desired expression level. We then built an automated platform based on a microfluidic device, a time-lapse microscopy apparatus, and a set of motorized syringes, all controlled by a computer. We tested the platform to force yeast cells to express a desired fixed, or time-varying, amount of a reporter protein over thousands of minutes. The computer automatically switched the type of sugar administered to the cells, its concentration and its duration, according to the control algorithm. Our approach can be used to control expression of any protein, fused to a fluorescent reporter, provided that an external molecule known to (indirectly) affect its promoter activity is available

Validation of two echocardiographic indexes to improve the diagnosis of complex coarctations

Objectives: Coarctation of the aorta is one of the most common congenital heart defects. Its diagnosis may be difficult in the presence of a patent ductus arteriosus, of other complex defects or of a poor echocardiographic window. We sought to demonstrate that the carotid-subclavian artery index (CSA index) and the isthmus-descending aorta ratio (I/D ratio), two recently described echocardiographic indexes, are effective in detection of isolated and complex aortic coarctations in children younger and older than 3 months of age. The CSA index is the ratio of the distal aortic arch diameter to the distance between the left carotid artery and the left subclavian artery. It is highly suggestive of a coarctation when it is ≪1.5. The I/D ratio defined as the diameter of the isthmus to the diameter of the descending aorta, suggests an aortic coarctation when it is less than 0.64. Methods: This is a retrospective cohort study in a tertiary care children's hospital. Review of all echocardiograms in children aged 0-18 years with a diagnosis of coarctation seen at the author's institution between 1996 and 2006. An age- and sex-matched control group without coarctation was constituted. Offline echocardiographic measurements of the aortic arch were performed in order to calculate the CSA index and I/D ratio. Results: Sixty-eight patients were included in the coarctation group, 24 in the control group. Patients with coarctation had a significantly lower CSA index (0.84±0.39 vs 2.65±0.82, p≪0.0001) and I/D ratio (0.58±0.18 vs 0.98±0.19, p≪0.0001) than patients in the control group. Associated cardiac defects and age of the child did not significantly alter the CSA index or the I/D ratio. Conclusions: A CSA index less than 1.5 is highly suggestive of coarctation independent of age and of the presence of other cardiac defects. I/D ratio alone is less specific than CSA alone at any age and for any associated cardiac lesion. The association of both indexes improves sensitivity and permits diagnosis of coarctation in all patients based solely on a bedside echocardiographic measuremen

Brugada syndrome in childhood: a potential fatal arrhythmia not always recognised by paediatricians. A case report and review of the literature

We report on a youngster followed by his paediatrician from birth until 14years of age for premature beats, most likely of ventricular origin. The sudden death of his sister provoked a re-assessment of his electrocardiograms (ECG), resulting in the diagnosis of Brugada syndrome and the subsequent implantation of a cardioverter defibrillator. This syndrome is a well known entity in adult cardiology, first described by Brugada and Brugada in 1992. It is considered to be the second most common cause of death in young adults after road traffic accidents. In children, however, the Brugada syndrome is not well known and we believe to be certainly underdiagnose

A noninvasive diagnostic tool to differentiate myocarditis from myocardial infarction: late gadolinium enhanced cardiac magnetic resonance

Studies in adults have shown that late gadolinium enhanced cardiac magnetic resonance is a safe and noninvasive diagnostic tool which allows one to differentiate myocardial infarction from myocarditis. We believe that it may also be highly useful in the paediatric population for the same purpos

DESIGN OF A LAMBDA CONFIGURATION IN ARTIFICIAL COHERENT NANOSTRUCTURES

The implementation of a three-level Lambda System in artificial atoms would allow to perform advanced control tasks typical of quantum optics in the solid state realm, with photons in the mu m/mm range. However hardware constraints put an obstacle since protection from decoherence is often conflicting with efficient coupling to external fields. We address the problem of performing conventional STImulated Raman Adiabatic Passage (STIRAP) in the presence of low-frequency noise. We propose two strategies to defeat decoherence, based on "optimal symmetry breaking" and dynamical decoupling. We suggest how to apply to the different implementations of superconducting artificial atoms, stressing the key role of non-Markovianity

Solidarity across group lines: secondary transfer effect of intergroup contact, perceived moral distance, and collective action

We tested, in three studies, whether the generalization of contact effects from primary to secondary outgroups—the secondary transfer effect (STE)—occurs for collective action. The results supported a serial mediation model: contact with immigrants by advantaged group members (Italians: Study 1, N = 146, 121 females, Mage = 28.31 years; Study 3, N = 406, 239 females, Mage = 36.35; British people, Study 2, N = 160, 113 females, Mage = 32.31) was associated with lower perceived moral distance toward primary outgroups, which in turn was associated with more positive attitudes and greater collective action intentions toward primary outgroups, and lower perceived moral distance toward secondary outgroups. Lower perceived moral distance toward secondary outgroups and stronger collective action intentions toward the primary outgroup were associated with higher collective action intentions toward secondary outgroups (results were inconsistent for attitudes). We discuss the findings with a focus on how a consideration of perceived moral distance extends current theorizing, and the relevance of generalized prejudice for the STE

Rapid estimation of the seismic impact through the active contribution of the civil protection volunteers

Immediately after an earthquake, a rapid estimation of the seismic impact is crucial to carrying out a prompt and appropriate Civil Protection response. This is particularly important in districts characterized by frequent and moderate-to-high seismicity, as is the case in the north-eastern part of Italy. In this paper, the authors illustrate an innovative approach developed in the Friuli Venezia Giulia Region (in north-eastern Italy), based on the active contribution of Civil Protection volunteers. The methodology is based on the rapid and pre-codified communication of the earthquake effects, focusing on two main aspects: (i) the observed effects on people and buildings in the urban areas, and (ii) the structural and non-structural damage observed on pre-identified buildings. In particular, this paper illustrates the methodology and its integration into the seismic emergency plans of the municipalities in the Friuli Venezia Giulia Region and discusses the first test, which occurred during a full-scale exercise and on the occasion of recent minor earthquakes affecting the area. \ua9 2016-OGS