Realization of Semantic Atom Blog

Web blog is used as a collaborative platform to publish and share information. The information accumulated in the blog intrinsically contains the knowledge. The knowledge shared by the community of people has intangible value proposition. The blog is viewed as a multimedia information resource available on the Internet. In a blog, information in the form of text, image, audio and video builds up exponentially. The multimedia information contained in an Atom blog does not have the capability, which is required by the software processes so that Atom blog content can be accessed, processed and reused over the Internet. This shortcoming is addressed by exploring OWL knowledge modeling, semantic annotation and semantic categorization techniques in an Atom blog sphere. By adopting these techniques, futuristic Atom blogs can be created and deployed over the Internet

The role of neutrophils and their proteases in allergic airway disease

An abundance of clinical data has demonstrated that a subset of asthmatic patients present with a neutrophilic infiltrate that is anticipated to be implicated in the pathology of the disease. However, this assumption is based largely on circumstantial evidence and the exact role of neutrophils in the pathophysiology of asthma has not been extensively explored. The aim of this thesis therefore was to elucidate the role of neutrophils in asthma by utilizing the house dust mite (HDM) murine model of allergic airway disease (AAD). We demonstrated that administration of HDM to different inbred mouse strains yielded very different inflammatory and airway remodelling profiles culminating variable airway hyperresponsiveness (AHR). Pertinently, whereas HDM-exposed 129/S2 mice exhibited a hyper-eosinophilic response, Balb/c mice presented with a mixed granulocytic response with a prominent neutrophilic component, which was TLR-4 independent. Specific depletion of neutrophils in HDM-exposed Balb/c mice was not protective but actually resulted in increased Th2 inflammation, with elevated ILC2s, Th2 CD4+ T cells, Th2 cytokines and serum IgE and IgG1 antibody responses. This elevated type 2 inflammation in neutrophil depleted animals was dependent on augmented Th2 cytokine production by ILC2s and a monocytosis that gave rise to enhanced antigen presentation. G-CSF was substantially elevated in neutrophil depleted mice and directly promoted the Th2 cytokine production by ILC2 and drove the monocytosis by acting on progenitors in the bone marrow. This data demonstrates that neutrophils may play a regulatory role in restricting Th2 inflammation rather than being strictly pathological. The enzyme leukotriene A4 hydrolase (LTA4H) regulates two distinct pathways that reciprocally regulate neutrophil recruitment. Classically, LTA4H functions intracellularly to generate the pro-inflammatory lipid mediator and potent neutrophil chemoattractant leukotriene B4 (LTB4). Accordingly, pharmaceutical companies have developed LTA4H inhibitors for the treatment of asthma, but they have failed to demonstrate efficacy in the clinic. Rationalizing the failure of these inhibitors, my lab have previously demonstrated a secondary extracellular anti-inflammatory role for LTA4H in degrading neutrophil chemoattractant Proline-Glycine-Proline (PGP). We have now demonstrated that mice lacking the LTB4 receptor, BLT1, showed reduced inflammation and AHR upon HDM exposure relative to wild type controls. Conversely, HDM treated lta4h-/- mice displayed an exacerbated airway resistance relative to littermate controls, despite being incapable of generating LTB4 and displaying reduced Th2 inflammation. This exacerbated airway resistance in lta4h-/- mice was attributable to a novel, neutrophil-independent, role for PGP in the context of AAD in driving pathological airway remodelling, with a pronounced epithelial hypertrophy and mucus hypersecretion apparent.Open Acces

Hyperuricemia prevalence in Indian subjects with underlying comorbidities of hypertension and/or type 2 diabetes: a retrospective study from subjects attending hyperuricemia screening camps

Background: To determine the prevalence of HU in Indian subjects attending the HU screening camps and in subjects with type 2 Diabetes Mellitus (T2DM), Hypertension (HTN), and T2DM+HTN.Methods: This was a retrospective, non-interventional study where medical records of subjects attending HU screening camps across 592 locations in India, between June 2017 to May 2018, were analyzed.Results: A total of 197097 subjects (T2DM: 19.69%; HTN: 14.08%; T2DM+HTN: 21.60%) attended the screening camps. Mean age of the study participants was 48.43±13.38 years (Male: 53.80%). A total of 48606(24.66%) subjects had HU. In the overall population, a higher proportion of subjects with T2DM + HTN (7.36%) had HU in comparison to subjects with T2DM (5.63%) and HTN (4.25%) alone. Similar results were reported when the data was evaluated only in HU subjects (T2DM+HTN: 29.85%; T2DM: 22.82%; HTN: 17.22%). Proportion of HU subjects increased with age, with the maximum prevalence evident in subjects aged >50 years (12.94%), followed by 30-50 years (10.65%) and 5 years or <2 years. Similar results were reported when the data was evaluated in the overall HU subjects and by indication.Conclusions: Authors observed a high prevalence of HU among subjects attending HU camps and those with associated comorbidities. The prevalence of HU was higher in males and has an increasing trend with age. Furthermore, the prevalence of HU was observed to be higher in subjects with 2-5 years of duration of T2DM and/or HTN

Estimation Of Target Movement In Wireless Sensor Network

Recently, Wireless Sensor Network (WSN) used in wide range of applications such as target detection and tracking, military and in environment monitoring. Target tracking can be implemented by face (polygon) based algorithm. We had considered technique of face tracking. Face is defined by Region Of Interest (ROI) which consist target like human, animal etc. Moving target detected by Face. For Face tracking we used brink detection algorithm because it consumes less energy and detect target easily also tracks the target continuously. Optimal node selection algorithm is used to select an optimal node for tracking. When target is lost they indicate that target is in which region. This drawback is overcome by increasing the area of face. Along with tracking it solves the problem of missing node as and when node failure occurs. Simulation results which compared with existing work and show that Face Track obtains better tracking results and power competence

Warfarin induced hematuria

Warfarin is an oral vitamin K antagonist prescribed to those patients for the treatment and prevention of thromboembolism. The major challenges to be faced during the therapy were a greater risk for both major as well as minor bleeding, which makes the regular monitoring of INR (international normalized ratio) mandatory. Herein, we reported a case of Warfarin induced hematuria which is serious and we concluded this causality as possible category according WHO-UMC causality category

Probabilistic Record Linkage with Elliptic Curve Operations

Federated query processing for an electronic health record infrastructure enables large epidemiology studies using data integrated from geographically dispersed medical institutions. However, government imposed privacy regulations prohibit disclosure of patient\u27s health record outside the context of clinical care, thereby making it difficult to determine which records correspond to the same entity in the process of query aggregation. Privacy-preserving record linkage is an actively pursued research area to facilitate the linkage of database records under the constraints of regulations that do not allow the linkage agents to learn sensitive identities of record owners. In earlier works, scalability has been shown to be possible using traditional cryptographic transformations such as Pohlig-Hellman ciphers, precomputations, data parallelism, and probabilistic key reuse approaches. This work proposes further optimizations to improve the runtime of a linkage exercise by adopting elliptic curve based transformations that are mostly additive and multiplicative, instead of exponentiations. The elliptic curve operations are used to improve the precomputation time, eliminate memory intensive comparisons of encrypted values and introduce data structures to detect negative comparisons. This method of record linkage is able to link data sets of the order of a million rows within 15 minutes. The approach has been gauged using synthetic and real world demographics data with parametric studies. We have also assessed the residual privacy risk of the proposed approach

Angiotensin II type 1 receptor blocker-induced immune thrombocytopenia: a case report

INTRODUCTION: The development of thrombocytopenia after a dose increase in losartan and subsequently after switching the patient to valsartan is reported. CASE PRESENTATION: A 61-year-old Caucasian man presented with epistaxis and gingival bleeding of three weeks duration. Laboratory evaluation revealed a hemoglobin level of 144g/L, a leukocyte count of 16.2×10(9) cells/L (72.51% neutrophils, 20.1% lymphocytes, 6.8% monocytes, 0.4% eosinophils, 0.2% bands), and a platelet count of 15.0×10(9) cells/L. Flow cytometry of his peripheral blood showed normal CD4:CD8 ratio and no evidence of any lymphoproliferative disorder. A peripheral smear showed decreased platelets with a few areas of clumping. Four weeks before presentation to the emergency room, his losartan dose was increased to 100mg once daily due to continuously elevated blood pressure readings. He had been maintained on losartan 50mg once daily for five years and previous routine laboratory measurements revealed a baseline platelet count of 248.0×10(9) cells/L. The patient began receiving an oral prednisone taper and his platelet count returned to a stable value of >200×10(9) cells/L. Because there was no other probable cause, he was thought to have developed immune thrombocytopenia from the increased losartan dose. Losartan was discontinued and one week later he was switched to valsartan 160mg once daily. Forty-seven days after starting valsartan, the patient presented once again to the emergency room with intermittent epistaxis and gingival bleeding while brushing his teeth of two weeks duration. Laboratory measurement revealed a platelet count of 37×10(9) cells/L. Valsartan was held and another prednisone taper was initiated. The patient’s platelet count recovered upon valsartan discontinuation and in four weeks, his platelet count improved to 214×10(9) cells/L. CONCLUSIONS: A 61-year-old Caucasian man developed immune thrombocytopenia after an increase in losartan dose and developed immune thrombocytopenia again after he was switched to valsartan