A Road Map toward Field-Effect Transistor Biosensor Technology for Early Stage Cancer Detection

Field effect transistor (FET)-based nanoelectronic biosensor devices provide a viable route for specific and sensitive detection of cancer biomarkers, which can be used for early stage cancer detection, monitoring the progress of the disease, and evaluating the effectiveness of therapies. On the road to implementation of FET-based devices in cancer diagnostics, several key issues need to be addressed: sensitivity, selectivity, operational conditions, anti-interference, reusability, reproducibility, disposability, large-scale production, and economic viability. To address these well-known issues, significant research efforts have been made recently. An overview of these efforts is provided here, highlighting the approaches and strategies presently engaged at each developmental stage, from the design and fabrication of devices to performance evaluation and data analysis. Specifically, this review discusses the multistep fabrication of FETs, choice of bioreceptors for relevant biomarkers, operational conditions, measurement configuration, and outlines strategies to improve the sensing performance and reach the level required for clinical applications. Finally, this review outlines the expected progress to the future generation of FET-based diagnostic devices and discusses their potential for detection of cancer biomarkers as well as biomarkers of other noncommunicable and communicable diseases

Optimization of electrocoagulation process for treatment of rice mill effluent using response surface methodology

The present work explores the impact of electro coagulation (EC) method on the treatment of waste from rice mill industries using two different electrode materials (Iron (Fe) and Aluminum (Al)). The influence of different parameters such as inter-electrode distance (4-7 cm), effluent pH (6-8), current density (10-30 mA/cm2) and treatment time (20-40 min) on the reduction of chemical oxygen demand (COD), total dissolved solids (TDS) and total soluble solids (TSS) of rice mill effluent (RME) was evaluated through batch experimental runs using BoxBehnken design. Results reveal that the percentage removal of COD, TDS and TSS increased up to an interelectrode distance of 6 cm, pH of 7, current density of 20 mA/cm2 and treatment time of 30 min and then decreased for both electrodes. In addition, mathematical models were developed for both electrodes in order to predict the experimental data. A numerical optimization method was applied to find out the optimal operating parameters to treat RME, and the percentage removal of COD, TDS and TSS was found to be 94.79, 96.62 and 88.76 %, using the Al electrode, as well as 76.63, 78.51 and 72.03 %, for the Fe electrode, respectively. The comparison of the results attained demonstrate that the Al electrode is more suitable to treat RME than Fe using EC method

Effects of Textural Properties on the Response of a SnO2-Based Gas Sensor for the Detection of Chemical Warfare Agents

The sensing behavior of SnO2-based thick film gas sensors in a flow system in the presence of a very low concentration (ppb level) of chemical agent simulants such as acetonitrile, dipropylene glycol methyl ether (DPGME), dimethyl methylphosphonate (DMMP), and dichloromethane (DCM) was investigated. Commercial SnO2 [SnO2(C)] and nano-SnO2 prepared by the precipitation method [SnO2(P)] were used to prepare the SnO2 sensor in this study. In the case of DCM and acetonitrile, the SnO2(P) sensor showed higher sensor response as compared with the SnO2(C) sensors. In the case of DMMP and DPGME, however, the SnO2(C) sensor showed higher responses than those of the SnO2(P) sensors. In particular, the response of the SnO2(P) sensor increased as the calcination temperature increased from 400 °C to 800 °C. These results can be explained by the fact that the response of the SnO2-based gas sensor depends on the textural properties of tin oxide and the molecular size of the chemical agent simulant in the detection of the simulant gases (0.1–0.5 ppm)

Biodegradable Electronic Devices

Recent progress in advanced health monitoring and therapeutic technologies, which chiefly relays on biocompatible or degradable electronics, has great possible to ease the environmentally friendly footmark of devices. Intricate biodegradable electronics entail biocompatible substrates, conductors, semiconductors, and insulators, all of which involve the vital construction blocks of devices. This chapter enumerates the modern trends in the approaches engaged to prepare biodegradable forms for each of these constituents. The biocompatible or degradable material includes nanomaterials, nanocomposites, conducting polymers, and other hybrid materials that can break down without full chemical breakdown and can be reused into other forms of building blocks that often need cautious synthetic methods, which will be discussed along with the outcomes. Significant development has been made in emerging degradable electronic device constituents; the mechanical and electrical assets of these materials must be enhanced beforehand completely degradable intricate electronics can be appreciated

Facile Synthesis and Characterization of Chitosan Nanofibers by Oil/Water Emulsion Method

A facial approach for the synthesis of surfactant free, biodegradable and eco-friendly chitosan nanofibers (CS-NFS) was prepared by Oil/Water Emulsion method. The morphology of the CS-NFS was examined by field emission scanning electron microscopy (FE-SEM). FE-SEM images show the nanoscale chitosan nanofibers formation with sizes in the ranges of ~100-200 nm. Physiochemical characterizations of the CS-NFS were analyzed by Fourier transform infrared spectroscopy (FT-IR), UV-visible spectroscopy and thermogravimetric analysis. The CS-NFS are expected to be useful in electrical, optical and electrochemical devices

Biocarbon Derived from Seeds of Palmyra Palm Tree for a Supercapacitor Application

Carbon-based materials are among the most promising materials for future electrochemical energy storage and conversion. Eco-friendly Palmyra palm seed derived microporous biocarbon was fabricated on the graphitic sheet. Palm seed derived carbon was carbonized by using 0.5 M H2S04 without any activating agent. Morphological characterization of PSDC investigated through SEM (Scanning Electron Microscopy). It shows PSDC is microporous with carbon network like structure. Physiochemical characterization performed through XRD, FT-IR and Raman studies. Raman studies confirm the PSDC having carbon based material. Electrochemical performance by using Cyclic voltammetry (CV), Galvanostatic charge discharge (GCD) and Electrochemical Impedance spectroscopy (EIS). PSDC exhibits the specific capacitance of 220 F/g at 5 A and 276.5 F/g at 1 A current as well as remarkable capacitance retention after 500 cycles is 63.1%. It shows PSDC having remarkable electrochemical storage application

Biocarbon Derived from Seeds of Palmyra Palm Tree for a Supercapacitor Application

Carbon-based materials are among the most promising materials for future electrochemical energy storage and conversion. Eco-friendly Palmyra palm seed derived microporous biocarbon was fabricated on the graphitic sheet. Palm seed derived carbon was carbonized by using 0.5 M H2S04 without any activating agent. Morphological characterization of PSDC investigated through SEM (Scanning Electron Microscopy). It shows PSDC is microporous with carbon network like structure. Physiochemical characterization performed through XRD, FT-IR and Raman studies. Raman studies confirm the PSDC having carbon based material. Electrochemical performance by using Cyclic voltammetry (CV), Galvanostatic charge discharge (GCD) and Electrochemical Impedance spectroscopy (EIS). PSDC exhibits the specific capacitance of 220 F/g at 5 A and 276.5 F/g at 1 A current as well as remarkable capacitance retention after 500 cycles is 63.1%. It shows PSDC having remarkable electrochemical storage application

Biocarbon Derived from Seeds of Palmyra Palm Tree for a Supercapacitor Application

Carbon-based materials are among the most promising materials for future electrochemical energy storage and conversion. Eco-friendly Palmyra palm seed derived microporous biocarbon was fabricated on the graphitic sheet. Palm seed derived carbon was carbonized by using 0.5 M H2S04 without any activating agent. Morphological characterization of PSDC investigated through SEM (Scanning Electron Microscopy). It shows PSDC is microporous with carbon network like structure. Physiochemical characterization performed through XRD, FT-IR and Raman studies. Raman studies confirm the PSDC having carbon based material. Electrochemical performance by using Cyclic voltammetry (CV), Galvanostatic charge discharge (GCD) and Electrochemical Impedance spectroscopy (EIS). PSDC exhibits the specific capacitance of 220 F/g at 5 A and 276.5 F/g at 1 A current as well as remarkable capacitance retention after 500 cycles is 63.1%. It shows PSDC having remarkable electrochemical storage application