2,812 research outputs found
MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients
Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream. Recently, circulating adipose-derived microRNAs (miRNAs) have been proposed as a novel class of adipokine, due to their capacity to regulate gene expression in tissues other than fat. Circulating levels of adipokines are known to be altered in obese individuals compared with typical weight individuals and are linked to poorer health outcomes. For example, obese individuals are known to be more prone to the development of some cancers, and less likely to achieve event-free survival following chemotherapy. The purpose of this review was twofold; first to identify circulating miRNAs which are reproducibly altered in obesity, and secondly to identify mechanisms by which these obesity-linked miRNAs might influence the sensitivity of tumors to treatment. We identified 8 candidate circulating miRNAs with altered levels in obese individuals (6 increased, 2 decreased). A second literature review was then performed to investigate if these candidates might have a role in mediating resistance to cancer treatment. All of the circulating miRNAs identified were capable of mediating responses to cancer treatment at the cellular level, and so this review provides novel insights which can be used by future studies which aim to improve obese patient outcomes
The generalized gradient approximation kernel in time-dependent density functional theory
A complete understanding of a material requires both knowledge of the excited
states as well as of the ground state. In particular, the low energy
excitations are of utmost importance while studying the electronic, magnetic,
dynamical, and thermodynamical properties of the material. Time-Dependent
Density Functional Theory (TDDFT), within the linear regime, is a successful
\textit{ab-initio} method to access the electronic charge and spin excitations.
However, it requires an approximation to the exchange-correlation (XC) kernel
which encapsulates the effect of electron-electron interactions in the
many-body system. In this work we derive and implement the spin-polarized XC
kernel for semi-local approximations such as the adiabatic Generalized Gradient
Approximation (AGGA). This kernel has a quadratic dependence on the wavevector,
{\bf q}, of the perturbation, however the impact of this on the electron energy
loss spectra (EELS) is small. Although the GGA functional is good in predicting
structural properties, it generality overestimates the exchange spin-splitting.
This leads to higher magnon energies, as compared to both ALDA and experiment.
In addition, interaction with the Stoner spin-flip continuum is enhanced by
AGGA, which strongly suppresses the intensity of spin-waves.Comment: 11 pages, 7 figure
Nutritive value of forage legumes used for grazing and silage
peer-reviewedLegume forages have an important position in ruminant production in Western Europe
and with further development can play an even larger role. Red clover for silage and white
clover in grazed swards lead to enhanced growth rate and milk yield in comparison with
pure grasses. Much of the production benefit of these legumes relates to enhanced intake
since digestibilities are not markedly different to grasses. The higher intake of legume
silages reflects differences in the cell structure of legume plants which combined with
high fermentation rates means that they break down into small particles in the rumen,
and leave the rumen more rapidly than perennial ryegrass. Ease of ingestion leads to
high rates of intake, which explains higher intakes for grazed legumes. A further benefit
of legumes is the reduced rate of decline in digestibility with advancing maturity. Whilst
legumes have limited effects on gross milk composition or carcass characteristics, there
are marked increases in levels of beneficial n−3 PUFA. Legumes have often led to a reduction
in methane production from the rumen and again, this relates to both physical and
chemical differences between forage species. The high rates of release of soluble protein
and of breakdown to small particles from clovers and lucerne is associated with susceptibility
to bloat, which is a limitation to further exploitation in grazing systems. The high
concentration of rapidly degraded protein in legumes also leads to inefficient utilisation
of dietary N and increased urinary N output. Research with tanniniferous forages, such
as birdsfoot trefoil and sulla, demonstrates the potential for future legumes with reduced
environmental and health effects, though these particular forage legumes are not well
adapted to temperate regions of Western Europe that are the focus of this review
Structuralism, indiscernibility, and physical computation
Structuralism about mathematical objects and structuralist accounts of physical computation both face indeterminacy objections. For the former, the problem arises for cases such as the complex roots i and -i, for which a (non-trivial) automorphism can be defined, thus establishing the structural identity of these importantly distinct mathematical objects (see e.g. Keranen in Philos Math 3:308-330, 2001). In the case of the latter, the problem arises for logical duals such as AND and OR, which have invertible structural profiles (see e.g. Shagrir in Mind 110(438):369-400, 2001). This makes their physical implementations indeterminate, in the sense that their structural profiles alone cannot establish whether a given physical component is an AND-gate or an OR-gate. Doherty (PhilPapers, https:// philpapers.org/ rec/DOHCI-3, 2021) has recently shown both problems to be analogous, and has argued that computational structuralism is threatened with the absurd conclusion that computational digits might be indiscernible, such that, if structural properties are all that we have to go on, the binary digit 0 must be treated as identical to the binary digit 1 (rendering pure structuralism absurd). However, we think that a solution to the indiscernibility problem for mathematical structuralists, drawing on the work of David Hilbert, can be adapted for the analogous problem in the computational case, thereby rescuing the structuralist approach to physical computation
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LENS® and SFF: Enabling Technologies for Optimized Structures
Optimized, lightweight, high-strength structures are needed in many applications from aerospace
to automotive. In pursuit of such structures, there have been proposed analytical solutions and
some specialized FEA solutions for specific structures such as automobile frames. However,
generalized 3D optimization methods have been unavailable for use by most designers.
Moreover, in the cases where optimized structural solutions are available, they are often hollow,
curving, thin wall structures that cannot be fabricated by conventional manufacturing methods.
Researchers at Sandia National Laboratories and the University of Rhode Island teamed to solve
these problems. The team has been pursuing two methods of optimizing models for generalized
loading conditions, and also has been investigating the methods needed to fabricate these
structures using Laser Engineered Net Shaping™ (LENS®) and other rapid prototyping
methods. These solid freeform fabrication (SFF) methods offer the unique ability to make
hollow, high aspect ratio features out of many materials. The manufacturing development
required for LENS to make these complex structures has included the addition of rotational axes
to Sandia’s LENS machine bringing the total to 5 controlled axes. The additional axes have
required new efforts in process planning. Several of the unique structures that are only now
possible through the use of SFF technology are shown as part of the discussion of this exciting
new application for SFF.Mechanical Engineerin
Persistence of characteristics of an ordered flux line lattice above the second peak in
We report Small Angle Neutron Scattering measurements of the flux lines
lattice (FLL) in . As previously reported, the
scattered intensity decreases strongly when the magnetic field is increased,
but it remains measurable far above the second peak. The direct observation of
Bragg peaks proves that the characteristics of a lattice are still present. No
structural features related to a symmetry breaking, such as a liquid like or an
amorphous state, can be observed. However, the associated scattered intensity
is very low and is difficult to explain. We discuss the coexistence between two
FLL states as a possible interpretation.Comment: accepted for publication in Phys Rev
A complete description of the magnetic ground state in spinel vanadates
Capturing the non-collinear magnetic ground state of the spinel vanadates
AVO (A= Mn, Fe and Co) remains an outstanding challenge for
state-of-the-art ab-initio methods. We demonstrate that both the non-collinear
spin texture, as well as the magnitude of local moments, are captured by a
single value of the on-site Hubbard of 2.7~eV in conjunction with the local
spin density approximation (LSDA+), provided the source term (i.e., magnetic
monopole term) is removed from the exchange-correlation magnetic field . We further demonstrate that the magnetic monopole structure in is highly sensitive to the value of , to the extent that the
interplay between on-site localization and local moment magnitude is
qualitatively different depending on whether the source term is removed or not.
This suggests that in treating strongly correlated magnetic materials within
the LSDA+ formalism, subtraction of the unphysical magnetic monopole term
from the exchange-correlation magnetic field is essential to correctly treat
the magnetic ground state.Comment: 4 pages, 3 figure
High magnetic field studies of the Vortex Lattice structure in YBa2Cu3O7
We report on small angle neutron scattering measurements of the vortex
lattice in twin-free YBa2Cu3O7, extending the previously investigated maximum
field of 11~T up to 16.7~T with the field applied parallel to the c axis. This
is the first microscopic study of vortex matter in this region of the
superconducting phase. We find the high field VL displays a rhombic structure,
with a field-dependent coordination that passes through a square configuration,
and which does not lock-in to a field-independent structure. The VL pinning
reduces with increasing temperature, but is seen to affect the VL correlation
length even above the irreversibility temperature of the lattice structure. At
high field and temperature we observe a melting transition, which appears to be
first order, with no detectable signal from a vortex liquid above the
transition
Competing spin transfer and dissipation at Co/Cu(001) interfaces on femtosecond timescales
By combining interface-sensitive non-linear magneto-optical experiments with
femtosecond time resolution and ab-initio time-dependent density functional
theory, we show that optically excited spin dynamics at Co/Cu(001) interfaces
proceeds via spin-dependent charge transfer and backtransfer between Co and Cu.
This ultrafast spin transfer competes with dissipation of spin angular momentum
mediated by spin-orbit coupling already on sub 100 fs timescales. We thereby
identify the fundamental microscopic processes during laser-induced spin
transfer at a model interface for technologically relevant ferromagnetic
heterostructures.Comment: 5 pages, 4 figure
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