Knot undulator to generate linearly polarized photons with low on-axis power density

Heat load on beamline optics is a serious problem to generate pure linearly polarized photons in the third generation synchrotron radiation facilities. For permanent magnet undulators, this problem can be overcome by a figure-8 operating mode. But there is still no good method to tackle this problem for electromagnetic elliptical undulators. Here, a novel operating mode is suggested, which can generate pure linearly polarized photons with very low on-axis heat load. Also the available minimum photon energy of linearly polarized photons can be extended much by this method

Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies

BACKGROUND: MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR=1.18, 95% CI=1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR=1.11, 95%CI=1.01-1.23, Pheterogeneity=0.210) and lung cancer risk (OR=1.25, 95%CI=1.06-1.46, Pheterogeneity=0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR=1.24, 95% CI=1.07-1.43, Pheterogeneity=0.006). CONCLUSIONS: These findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers

Changes of Biochemical Components Contents and Gene Expression Profiles in Tissues of Litopenaeus vannamei During Spermatophore Regeneration

Spermatophore regeneration is an important biological process in Litopenaeus vannamei. In this study, changes of biochemical components contents during spermatophore regeneration showed that in hemolymph, the glucose content significantly increased from day 2 to day 8 and then decreased from day 10 to day 12; triglyceride (TG) and total cholesterol (TC) contents were relatively stable. In the hepatopancreas, glucose, and TG contents significantly decreased during regeneration; TC contents significantly increased at day 4 and then decreased. In the testes, glucose content significantly increased while TC content significantly decreased during whole stage; TG content at day 4 was highest. In terminal ampoule, changes of glucose and TC contents were similar, the contents at day 4 were highest; TG content at day 6 was significantly lower than day 2. During spermatophore regeneration, expression level of pyruvate kinase (PK) was significantly higher during day 2 to day 4 than at other times, and expression levels of three lipogenesis-related genes diacylglycerol O-acyltransferase homolog 1 (DGAT1), sterol regulatory element-binding protein 1 (SREBP1) and sterol O-acyltransferase 2 (SOAT2) were significantly higher during day 2 to day 8 than at other times. The results indicated that the hepatopancreas could be the energy source that provides glucose and TG; glucose, TG, and TC play important roles in spermatophore regeneratio