Plasma levels of bigET-1, ET-1, ET-2 and ET-3 peptides in animals treated with AEOL.

<p>Mean ± SE, n = 6 animals per group. <b>A.</b> BigET-1: NS. <b>B.</b> ET-1: Two-way ANOVA. TIME main effect, p = 0.042. Holm-Sidak: <b>a</b>, 2 h vs 24 h, p < 0.05. AEOL main effect, p = 0.001. Holm-Sidak: <b>b</b>, 0, 2 vs 5 mg/kg, p < 0.001. <b>C.</b> ET-2: NS. <b>D.</b> ET-3: Two-way ANOVA. AEOL main effect, p = 0.014. Holm-Sidak: <b>c</b>, 2 vs 5 mg/kg, p = 0.004.</p

Lung and heart eNOS and iNOS mRNA.

<p>Mean ± SE, n = 6 animals per group. <b>A.</b> Lung eNOS: NS. <b>B.</b> Heart eNOS: NS. <b>C.</b> Lung iNOS: Two-way ANOVA. TIME x AEOL interaction, p < 0.001. Holm-Sidak: <b>a</b>, AEOL within 2 h: 0, 2 vs 5mg/kg, p < 0.001. <b>b</b>, AEOL within 24 h: 0 vs 5 mg/kg, p = 0.047. <b>D.</b> Heart iNOS: NS.</p

Lung and heart ET_A receptor and ET_B receptor mRNA.

<p>Mean ± SE, n = 6 animals per group. <b>A.</b> Lung ET_AR. Two-way ANOVA. AEOL main effect, p = 0.045. Holm-Sidak: <b>a</b> 0 vs 5 mg/kg, p = 0.014. <b>B.</b> Heart ET_A mRNA: NS. <b>C.</b> Lung ET_BR: Two-way ANOVA. TIME main effect, p = 0.028. Holm-Sidak: <b>b</b>, 2 vs 24 h, p < 0.05. <b>D.</b> Heart ET_B mRNA: NS.</p

Plasma levels of isoprostane and 3-nitrotyrosine in animals treated with AEOL.

<p>Mean ± SE, n = 6 animals per group. <b>A</b>. Plasma isoprostane: Two-way ANOVA. AEOL main effect, p = 0.036. Holm-Sidak: <b>a</b>, 0 vs 2 mg/kg, p = 0.011. <b>B</b>. Plasma 3-nitrotyrosine: Two-way ANOVA. AEOL main effect, p = 0.003. Holm-Sidak: <b>b</b>, 0 vs 5 mg/kg, p < 0.001, and 2 vs 5 mg/kg, p < 0.040.</p