3,016 research outputs found
Relation of blood pressure variability to carotid atherosclerosis and carotid artery and left ventricular hypertrophy.
Relation of arterial structure and function to left ventricular geometric patterns in hypertensive adults
Impact of arterial elastance as a measure of vascular load on left ventricular geometry in hypertension
Is the absence of a normal nocturnal fall in blood pressure (nondipping) associated with cardiovascular target organ damage?
Assessment of arterial compliance by carotid midwall strain-stress relation in normotensive adults
Cardiac and arterial target organ damage in adults with elevated ambulatory and normal office blood pressure
Lack of Reduction of Left Ventricular Mass in Treated Hypertension: The Strong Heart Study
BACKGROUND: Hypertensive left ventricular mass (LVM) is expected to decrease during antihypertensive therapy, based on results of clinical trials. METHODS AND RESULTS: We assessed 4‐year change of echocardiographic LVM in 851 hypertensive free‐living participants of the Strong Heart Study (57% women, 81% treated). Variations of 5% or more of the initial systolic blood pressure (SBP) and LVM were categorized for analysis. At baseline, 23% of men and 36% of women exhibited LV hypertrophy (LVH, P<0.0001). At the follow‐up, 3% of men and 10% of women had regression of LVH (P<0.0001 between genders); 14% of men and 15% of women, free of baseline LVH, developed LVH. There was an increase in LVM over time, more in men than in women (P<0.001). Participants whose LVM did not decrease had similar baseline SBP and diastolic BP, but higher body mass index (BMI), waist/hip ratio, heart rate (all P<0.008), and urinary albumin/creatinine excretion (P<0.001) than those whose LVM decreased. After adjusting for field center, initial LVM index, target BP, and kinship degree, lack of decrease in LVM was predicted by higher baseline BMI and urinary albumin/creatinine excretion, independently of classes of antihypertensive medications, and significant effects of older age, male gender, and percentage increase in BP over time. Similar findings were obtained in the subpopulation (n=526) with normal BP at follow‐up. CONCLUSIONS: In a free‐living population, higher BMI is associated with less reduction of hypertensive LVH; lack of reduction of LVM is independent of BP control and of types of antihypertensive treatment, but is associated with renal damage
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