Distribution of lactate between the corpuscles and the plasma in blood

1. The ratio of the concentration of lactate in the corpuscles to that in the plasma (C/P ratio) is 0.6-0.9 in the blood of resting animals (cat, horse, man). 2. In the blood of fatigued animals (cat, rabbit, man) it is reduced to 0.5-0.6. 3. This change in the C/P ratio is not due to a delay in the diffusion of lactate from the plasma into the corpuscles, nor to the presence, either in the corpuscles or plasma, of some indiffusible substance estimated as lactate. 4. The C/P ratio is raised by (a) increased partial pressure of carbon dioxide; (b) decreased partial pressure of oxygen; (c) increased H-ion concentration These facts lead to the conclusion that a "lactate shift" analogous to the "chloride shift" occurs during each respiratory cycle of the blood, which may become of importance in connexion with the buffering of the blood in conditions of severe oxygen debt. 5. The C/P ratio is reduced by an increased concentration of lactate in the whole blood. 6. The increased lactate content of the blood occurring in conditions of oxygen debt is shown to be more than sufficient to account for the fall observed in the C/P ratio. The discrepancy is at least partly explained by the opposing effects of the simultaneous changes in carbon dioxide and oxygen partial pressures

The Results of Treatment with Streptomycin Plus Pyrazinamide in Patients with Active Pulmonary Tuberculosis Despite Prolonged Treatment with Isoniazid Plus PAS

This report presents the findings during a year or more of observation of 20 South Indian patients who, after an initial course of isoniazid plus PAS, were treated with streptomycin plus pyrazinamide for active pulmonary tuberculosis. The combination of streptomycin plus pyrazinamide was chosen, first, because of its likely therapeutic effectiveness, since all the patients had streptomycin-sensitive strains of bacilli, secondly, because it presented an opportunity to study supervised drug administration in domiciliary patients in a community in which the selfadministration of antituberculosis drugs could not be depended on (Fox, 1958 ; Tuberculosis Chemotherapy Centre, 1959, 1960 ; Velu et al., 1960). The patients were either unsuitable for or unwilling to undergo surgery

Comparative studies on the nutritive value of fish and prawn muscle

This article does not have an abstract

Compounds of phosphorus in milk-I

This article does not have an abstract

Multiattribute electronic procurement using goal programming

One of the key challenges of current day electronic procurement systems is to enable procurement decisions transcend beyond a single attribute such as cost. Consequently, multiattribute procurement have emerged as an important research direction. In this paper, we develop a multiattribute e-procurement system for procuring large volume of a single item. Our system is motivated by an industrial procurement scenario for procuring raw material. The procurement scenario demands multiattribute bids, volume discount cost functions, inclusion of business constraints, and consideration of multiple criteria in bid evaluation. We develop a generic framework for an e-procurement system that meets the above requirements. The bid evaluation problem is formulated as a mixed linear integer multiple criteria optimization problem and goal programming is used as the solution technique. We present a case study for which we illustrate the proposed approach and a heuristic is proposed to handle the computational complexity arising out of the cost functions used in the bids

A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis

ATI earlier report from this Centre (Tuber-culosis Chemotherapy Centre, Madras, 1964) showed that a fully supervised twice-weekly regimen of streptomycin plus high-dosage isoniazid was highly effective in the treatment of patients with newly-diagnosed bacteriologi-cally confirmed pulmonary tuberculosis. How-ever, this regimen involves intramuscular injections of streptomycin and may not always be easy to organize, especially in rural areas and in developing countries with limited resources. For this reason, it was decided to investigate the possibility of replacing strepto-mycin in the twice-weekly regimen by two oral drugs, namely ethionamide and PAS. Ethiona-mide was chosen since, apart from isoniazid and streptomycin, it was the most potent drug available at the time, and PAS was included with a view to enhance the efficacy of the regimen. Finally, it was decided that the patients should be given an intensive phase of daily treatment with streptomycin, PAS and isoniazid for two weeks. Experiments in the guinea-pig had shown that the size of the individual dose of a drug needed to be increased as the interval between successive doses was increased (Dickinson & Mitchison, 1966). As PAS is bulky and the dosage of isoniazid in the twice-weekly regimen was already high, namely 15 mg./kg. body-weight, it was decided to explore the possibility of increasing the dosage of ethionamide to a level higher than that usually employed (0.5— 1.0 g.) in daily regimens. An investigation was therefore undertaken to determine the maximum tolerated dose of ethionamide. when administered twice-weekly together with isonia-zid plus PAS. Since the assessment of ethio-namide intolerance is largely subjective, the study was conducted ‘double-blind’ with respect to the dosage of ethionamide

Arthralgia in South Indian patients with pulmonary tuberculosis during treatment with pyrazinamide and rifampicin

Arthralgia was the major adverse reaction encountered in a clinical trial of the treatment of pulmonary tuberculosis with three short-course regimens containing pyrazinamide in South Indian patients. The first regimen was of rifampicin, streptomycin, isoniazid and pyrazinamide given daily for three months; the second was of the same four drugs daily for three months followed by streptomycin, isoniazid and pyrazinamide twice-weekly for two months, and the third was the same as the second except that rifampicin was not administered. Arthralgia was reported in 36% of 353 rifampicin patients and 66% of 179 non-rifampicin patients, a highly significant difference (p<0.001). The onset of arthralgia was mostly during the first two months of chemotherapy. The knees were affected in about 90% followed by the ankles in about 50% of the patients with arthralgia, and about 60% of these patients had one or more of the signs, swelling, tenderness and limitation of joint movement. Chemotherapy was modified in 10 rifampicin and 15 non-rifampicin patients; the rest of the patients were managed with symptomatic treatment with analgesics. There was a two to three fold increase in serum uric acid concentrations by the end of the first month and the concentrations were more or less stationary throughout the rest of the daily phase of treatment. The mean concentration during the daily phase of treatment in patients with arthralgia (0.482 mmoles/litre) was similar to that in those without arthralgia (0.484 mmoles/litre), while that in the rifampicin patients (0.476 mmoles/litre) was significantly lower (p=0.03) than that in the non-rifampicin patients (0.495 mmoles/litre)