The Results of Treatment with Streptomycin
Plus Pyrazinamide in Patients with Active
Pulmonary Tuberculosis Despite Prolonged
Treatment with Isoniazid Plus PAS
This report presents the findings during a year or more of observation of
20 South Indian patients who, after an initial course of isoniazid plus PAS, were
treated with streptomycin plus pyrazinamide for active pulmonary tuberculosis. The
combination of streptomycin plus pyrazinamide was chosen, first, because of its
likely therapeutic effectiveness, since all the patients had streptomycin-sensitive
strains of bacilli, secondly, because it presented an opportunity to study supervised
drug administration in domiciliary patients in a community in which the selfadministration
of antituberculosis drugs could not be depended on (Fox, 1958 ;
Tuberculosis Chemotherapy Centre, 1959, 1960 ; Velu et al., 1960). The patients were
either unsuitable for or unwilling to undergo surgery
