Socio-demographic correlates of mental and behavioural disorders of children in Southern Ethiopia

Objective: To describe the magnitude and socio-demographic correlates of specific mental and behavioural disorders.Design: A cross-sectional survey.Setting: Butajira district, southern Ethiopia.Participants: The Amharic version of the Diagnostic Instrument for Children and Adolescents (DICA) was used to interview parents of 1,477 children.Main outcome measures: Attention Deficit Hyperactivity Disorder (ADHD), Disruptive behaviour disorders, mood and anxiety disorders.Results: Using a multivariate logistic model, age was significantly associated with ADHD. Children between 10 and 14 years of age had more than three-fold increased risk of ADHD compared to younger children: adjusted odds ratio and 95% confidence interval (OR, 95%CI) = 3.17 (1.16, 8.67), p=0.02. Residence in urban area was also significantly associated with ADHD: adjusted OR (95% CI) = 2.84 (1.14-7.07), p=0.03. Disruptive behaviour disorders were significantly associated with increasing age: adjusted OR (95% CI)= 4.24 (1.43, 12.6). Mood and anxiety disorders were not significantly associated with any of the sociodemographic variable studied.Conclusion: The study shows that age and residence in urban areas are significant correlates of behavioural disorders in children

Neuronal Activity Within the Ventral Tegmental Area Is Correlated with Cocaine-Seeking Behavior in Male, But Not Female, Rats

The objective of this study was to begin to determine the neurobiological underpinnings of psychosocial stress-induced cocaine seeking. Social defeat stress, achieved using the well-established resident-intruder procedure, is an ecologically-valid psychosocial stressor in rodents that may more closely recapitulate those psychosocial experiences that elicit cocaine craving and relapse in human cocaine users. Our laboratory has developed a model of psychosocial stress-induced relapse in rats in which extinguished cocaine seeking is reinstated by re-exposure to a discrete cue that signals impending social defeat stress. We previously reported that an individual rat’s predilection towards the display of active coping behaviors during prior social defeat stress exposures was positively correlated with levels of psychosocial stress-induced cocaine seeking. The current study’s goal was to expand upon these initial findings by assessing and comparing patterns of neural activation within the ventral tegmental area (VTA) during stress-induced cocaine seeking triggered by psychosocial stress-predictive or foot shock stress-predictive cues. The VTA was selected for investigation in the present study because of its known role in the manifestation of stress-induced reinstatement of cocaine seeking. We postulated that neural activation in this brain region would be associated with the magnitude of observed psychosocial stress-induced cocaine seeking, thus providing important insights into the neurobiological underpinnings of this phenomenon

Child labor and childhood behavioral and mental health problems in Ethiopia

Background: According to ILO estimates, at least 180 million children aged 5 to 14 years are currently engaged in fulltime work in the developing countries. However, very little information exists about childhood behavioral and mental disorders in Ethiopia. Objective: The objectives of this study are to estimate the prevalence and describe the nature of behavioral and mental health problems, as well as child abuse, nutritional problems, gross physical illness and injury among child laborers aged 8 to 15 years in Ethiopia. However, only the behavioral and mental health problems of the study population are examined here. Methods: A cross-sectional survey of children aged 8 to 15 years, and who were engaged in fulltime work in different formal and informal sectors non-laborers, was conducted in four major towns of Ethiopia. The screening instrument known as Reported Questionnaire on Children (RQC) and a diagnostic instrument known as the Diagnostic Interview for Children and Adolescents ( DICA) were used to detect symptoms and signs of behavioral and mental problems in the children. br> Results: A total of 2000 child laborers and 400 non-laborers were interviewed using RQC to screen for probable cases of behavioral and mental problems. Of these, 50% of the laborers and 42% of the non-laborers were males. The mean age of the laborers was 13.8 ±1.8 years while that of the non-laborers was 12.2 ±2.1 years. More females (76.8%) were found to have been engaged in domestic labor than males. The RQC interview screened 9.4% (n=226) of the children as probable cases of mental/ behavioral disorders, (14.0% non-laborers and 8.5% laborers). The second stage DICA interview gave an overall prevalence of 5.5% (4.9% in laborers and 8.8% in non-laborers). Conclusion: The prevalence of childhood behavioral and mental disorders in this study is within the range reported in previews studies conducted on children of the same age group. However, the lower prevalence of childhood disorders in the child laborers compared to that of the non-laborers found in the current study is probably due to selection bias or healthy workers effect. Thus, further study is recommended to explain this unexpected finding. The Ethiopian Journal of Health Development Vol. 20 (2) 2006: 119-12

Gene expression profiles of 4‐hydroxy‐N‐desmethyl‐tamoxifen (endoxifen)‐ and 4‐hydroxy‐tamoxifen (4OHTAM)‐treated human breast cancer cells determined by CDNA microarray analysis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109798/1/cptclpt2004192.pd