Serum folate and B12 levels in association with cognitive impairment among seniors: results from the VELESTINO study in Greece and meta-analysis.

OBJECTIVE: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( > 65 years) residing in Velestino, Greece. METHOD: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. RESULTS: Cognitive impairment (MMSE < 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). DISCUSSION: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored

Incidence and risk factors of fall injuries among infants: a study in Greece.

OBJECTIVE: To assess the incidence of fall injuries among infants in Greece, overall and by type of nursery equipment. DESIGN: Review of data from a large injury database. SETTING: The Emergency Department Injury Surveillance System in Greece. PATIENTS: A total of 2672 injured infants. INTERVENTIONS: Specially trained health visitors performed in-person interviews with the children's guardians, using a precoded questionnaire. The results of an independent survey of 777 mothers of noninjured children younger than 2 years attending the same emergency departments were used to allow quantification of the role of specific nursery equipment in the causation of infant fall injuries. MAIN OUTCOME MEASURES: Annual rate of injury by falling in infants, overall and by cause. RESULTS: About 4400 infant fall injuries occur annually in Greece, corresponding to an annual incidence rate of 44 injuries per 1000 infants. The incidence of falls increases with increasing infant age. A high percentage of severe injuries was detected, most of them concussions (14.3%) and fractures (9.4%). Approximately 10% of infants with fall-related injuries required hospitalization. More than 36% of fall injuries involved nursery equipment. Infant walker use was associated with a higher incidence of falls (about 9 per 1000 infant-years), and these falls occasionally involved stairs and caused serious injuries. Infant bouncers, strollers, and changing tables were all associated with a similar incidence of falls (about 4 per 1000 infant-years). CONCLUSIONS: Falls are a common cause of serious infant injuries, and nursery equipment is frequently involved in the injury-causing event

Association of clinical and epidemiological characteristics with COVID-19 BNT162b2 mRNA vaccine short-term adverse reactions in healthcare workers

Introduction The aim of the study was to investigate the prevalence and severity of adverse reactions (ARs) after immunization of healthcare workers (HCWs) with BNT162b2 vaccine and to associate them with clinical and epidemiological characteristics. Methods A form containing demographic and clinical data as well as ARs after both doses of the vaccine was completed, and statistical association analysis was performed. Results A total of 502 HCWs (females 78.3%) with mean age (±SD) 48.17 years (±12.97) participated. After the first dose, 404 (80.5%) HCWs reported at least one local AR (LAR) and 366 (72.9%) after the second dose (p-value=0.004). After the first dose, 121 (24.1%) HCWs reported at least one systemic AR (SAR) and 275 (54.8%) after the second dose (p-value<0.0001). In the logistic regression analysis, there was no association of gender or medical history of underlying disease with LARs. There was a negative association of age with the cumulative score (CS) of LARs (OR: 0.82, 95% CI: 0.69–0.96) after the first dose. Females had a positive association with CS of SARs following both doses (OR, 95% CI: 2.57, 1.39–4.73 and 2.71, 1.76–4.19, respectively). Age was negatively associated with CS of SARs (OR: 0.66, 95% CI: 0.57–0.76) after the second dose. Severe ARs included Bell’s palsy (1) and tinnitus with temporary hearing loss (1). Conclusion The administration of the BNT162b2 vaccine in our HCWs cohort had a good safety profile with the most common ARs being self-limited. An increasing rate of SARs following the second vaccine dose was noticed. Rare but severe possible ARs should be further investigated

Epidemiological patterns and preventability of traumatic hand amputations among adults in Greece

Introduction: Hand/finger amputations though rare account for significant disability and health-related costs; yet, information on underlying causes, springing mostly from physicians’ reports, is rather anecdotal. We sought to draw attention to the high preventable fraction of hand/finger amputations among adults in Greece. Patients and Methods: Data on external cause of injury and short-term outcome, recorded over nine years in the Emergency Department Injury Surveillance System (EDISS) were analysed, whereas sample weights were used for nationwide extrapolations. Results: Hand/finger injuries accounted for 20.4% (N = 57,986) among 284,705 injuries recorded in patients &gt; 14-year-old (3% annual probability); 728 (1.3%) resulted in amputations; the estimated incidence rate (IR) was 39.3/100,000 person-years, reaching a high 92.6/100,000 among males aged 4564 years. As expected, the vast majority of victims were males (90%), frequently young immigrants; similar to two-thirds sustained occupational injuries during working hours. Objects most frequently involved included: machinery (57% overall/69% occupational), means of transport (10.4%), materials (9.5%), parts of buildings/furniture (5%). Wood-working was the most common risk factor (20% overall/28% occupational) whereas 6% of victims accepted own inattention. 30% of amputations were hospitalised whereas 10% transferred to specialised units. Discussion: Specialised registries reveal the magnitude and specific causes of disabling hand injuries and point to tailored national injury prevention programs; specifically in Greece, as they occur in more controlled occupational environments among middle-aged males, woodworkers, and are caused mainly by machinery. Conclusions: Increased management of safety in the workplace could play a role in reduction in hand amputations. (C) 2012 Elsevier Ltd. All rights reserved

Monitoring the carbon footprint of dry bulk shipping in the EU: An early assessment of the MRV regulation

Aiming at reducing CO2 emissions from shipping at the EU level, a system for monitoring, reporting, and verification (MRV) of CO2 emissions of ships was introduced in 2015 with the so-called &lsquo;MRV Regulation&rsquo;. Its stated objective was to produce accurate information on the CO2 emissions of large ships using EU ports and to incentivize energy efficiency improvements by making this information publicly available. On 1 July 2019, the European Commission published the relevant data for 10,880 ships that called at EU ports within 2018. This milestone marked the completion of the first annual cycle of the regulation&rsquo;s implementation, enabling an early assessment of its effectiveness. To investigate the value of the published data, information was collected on all voyages performed within 2018 by a fleet of 1041 dry bulk carriers operated by a leading Danish shipping company. The MRV indicators were then recalculated on a global basis. The results indicate that the geographic coverage restrictions of the MRV Regulation introduce a significant bias, thus prohibiting their intended use. Nevertheless, the MRV Regulation has played a role in prompting the IMO to adopt its Data Collection System that monitors ship carbon emissions albeit on a global basis

Clustering of excess health concerns for electromagnetic fields among health personnel: A quantitative and qualitative approach

Clustering patterns, among health-care personnel, of excessive concerns pertaining to perceived electromagnetic field-related health impacts, as contrasted to those from other environmental factors, were explored. Knowledge/excessive concerns of 722 health-care personnel were assessed using a 22-item structured questionnaire along with a double-phase qualitative study comprising semistructured interviews and focus groups. Over 75 percent of the participants had high perceived knowledge, whereas accuracy was limited to &lt;20 percent and correctness to 8 percent. An excessive concern group was clearly distinguished from a relaxed attitude one. Clustering of excessive concerns may derive from personal beliefs, suggesting a risk governance issue for health education policies

Unintentional injury mortality in the European Union: How many more lives could be saved?

Aims: The wide variation of unintentional ( accidental) injury mortality rates in the European Union (EU) member states suggests that there is high potential for prevention. This paper attempts to quantify the potential for saving lives in this part of the world if all 25 member states were to learn from the experience of countries with advanced injury prevention records. Methods: Unintentional injury mortality data ( latest three available years), including denominator population estimates, were obtained from the World Health Organization ( WHO) mortality database for all 22 EU countries with a population of more than one million. Annual average age-adjusted injury mortality rates were used to derive the potential for saving of lives under two scenarios: ( a) if all EU member states matched the country with the lowest unintentional rate for all causes of injury combined; (b) if the benchmark was alternatively the country with the lowest unintentional injury cause-specific rate. Separate calculations were performed for children ( 0 - 14), adults ( 15 - 64), and the elderly ( 65 and over). Results: Under the first scenario, over 73,000 lives could have been saved in the EU 25 in a single year, notably nearly half (47.4%) fewer unintentional injury deaths could be observed in children, over half in adult (54%), and two-fifths (38%) in the elderly. Under the second, more optimistic, scenario 59% of childhood and adult and 75% of unintentional injury deaths among the elderly would have been avoided. Conclusions: A substantial proportion of lives lost due to unintentional injury might be saved if all countries were to achieve the lowest unintentional injury mortality rates in the EU. The above calculations are based on a simple theoretical model but there is increasing evidence on the array of existing effective preventive interventions and improved trauma care calls for public health action in each member state that could in practice halt, to the extent possible, the unintentional injury epidemic

Magnitude and object-specific hazards of aspiration and ingestion injuries among children in Greece.

OBJECTIVE: To assess the public health impact of injuries due to foreign body aspirations and ingestions among children in terms of overall magnitude and estimation of object-specific incidence. METHODOLOGY: Two thousand two hundred and seven injuries due to aspiration and ingestion of foreign bodies were identified among 110 066 records of children (less than 15 years old) collected by the Hellenic Emergency Department Injury Surveillance System (EDISS) during the 5-year study period 1996-2000. Countrywide estimates of overall and object-specific injury incidence rates were computed using appropriate age and place of residence-sampling ratios. Simple cross-tabulations were performed along with a free text description analysis of injury events, whereas a composite score using (1) frequency of injury occurrence, (2) hospitalisation rate and (3) average length of hospitalisation was developed to measure the overall object-specific burden of injuries. RESULTS: Aspirations and ingestions of foreign bodies accounted for 2% of the total burden of accident and emergency department visits, corresponding to an annual incidence of approximately 2.3 accidents per 1000 children. Fish bones and nuts prevailed among the high (44%) proportion of aspirations and ingestions due to edible foreign bodies, while the main inedibles involved were small objects. Toddlers, boys and migrant children were over-represented among children sustaining injuries due to inedibles. As expected, the vast majority of food-related injuries occurred in the kitchen, in most instances under parental supervision. Injuries due to edibles were of minor severity and treatment was provided in the emergency departments, while those due to inedibles were responsible for injuries resulting in higher hospitalisation rates, albeit of relatively short duration. The composite impact score was highest for nuts and other food, nails, pins and sharp instruments. X-rays were performed in nearly all cases; upper gastrointestinal endoscopy was required in about 1 out of 10 instances and laryngoscopy or bronchoscopy in 1 out of 20, whereas the object was spontaneously removed in less than 3% of the cases. CONCLUSIONS: Depending on whether caused by edible or inedible objects, injuries due to foreign body aspirations and ingestions showed distinct epidemiological patterns. Composite scores taking into account measures of injury frequency and severity, seemed to reflect a country-specific spectrum of this type of injuries and provided useful information for the design of targeted public health oriented interventions