1,333 research outputs found

    Reachability Based Web Page Ranking Using Wavelets

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    AbstractA naïve approach has been made by applying the concept of reachability for web page ranking and implementing multi resolution analysis using Haar wavelet to order the web pages. In this article, page ranking has been done by developing a structured signal using in links, out links and reachability values of the web pages of network graphs. Using Haar wavelet, the page ranking is proposed and developed. The average and detailed coefficients of the input signal and the down sampling process provides the necessary page ranking of web pages. This approach does not involve any iterative technique, damping factor or initialization of the page ranks. In this paper, comparison between the original page rank, category-based page rank and the proposed approach have been made. The result reflects the role of paths between the pages in page rankings

    GP-Unet: Lesion Detection from Weak Labels with a 3D Regression Network

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    We propose a novel convolutional neural network for lesion detection from weak labels. Only a single, global label per image - the lesion count - is needed for training. We train a regression network with a fully convolutional architecture combined with a global pooling layer to aggregate the 3D output into a scalar indicating the lesion count. When testing on unseen images, we first run the network to estimate the number of lesions. Then we remove the global pooling layer to compute localization maps of the size of the input image. We evaluate the proposed network on the detection of enlarged perivascular spaces in the basal ganglia in MRI. Our method achieves a sensitivity of 62% with on average 1.5 false positives per image. Compared with four other approaches based on intensity thresholding, saliency and class maps, our method has a 20% higher sensitivity.Comment: Article published in MICCAI 2017. We corrected a few errors from the first version: padding, loss, typos and update of the DOI numbe

    Distance Metric Learning using Graph Convolutional Networks: Application to Functional Brain Networks

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    Evaluating similarity between graphs is of major importance in several computer vision and pattern recognition problems, where graph representations are often used to model objects or interactions between elements. The choice of a distance or similarity metric is, however, not trivial and can be highly dependent on the application at hand. In this work, we propose a novel metric learning method to evaluate distance between graphs that leverages the power of convolutional neural networks, while exploiting concepts from spectral graph theory to allow these operations on irregular graphs. We demonstrate the potential of our method in the field of connectomics, where neuronal pathways or functional connections between brain regions are commonly modelled as graphs. In this problem, the definition of an appropriate graph similarity function is critical to unveil patterns of disruptions associated with certain brain disorders. Experimental results on the ABIDE dataset show that our method can learn a graph similarity metric tailored for a clinical application, improving the performance of a simple k-nn classifier by 11.9% compared to a traditional distance metric.Comment: International Conference on Medical Image Computing and Computer-Assisted Interventions (MICCAI) 201

    Extracting the Groupwise Core Structural Connectivity Network: Bridging Statistical and Graph-Theoretical Approaches

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    Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuro-science. Recent evidence suggests there's a tightly connected network shared between humans. Obtaining this network will, among many advantages , allow us to focus cognitive and clinical analyses on common connections, thus increasing their statistical power. In turn, knowledge about the common network will facilitate novel analyses to understand the structure-function relationship in the brain. In this work, we present a new algorithm for computing the core structural connectivity network of a subject sample combining graph theory and statistics. Our algorithm works in accordance with novel evidence on brain topology. We analyze the problem theoretically and prove its complexity. Using 309 subjects, we show its advantages when used as a feature selection for connectivity analysis on populations, outperforming the current approaches

    Spectral Graph Convolutions for Population-based Disease Prediction

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    Exploiting the wealth of imaging and non-imaging information for disease prediction tasks requires models capable of representing, at the same time, individual features as well as data associations between subjects from potentially large populations. Graphs provide a natural framework for such tasks, yet previous graph-based approaches focus on pairwise similarities without modelling the subjects' individual characteristics and features. On the other hand, relying solely on subject-specific imaging feature vectors fails to model the interaction and similarity between subjects, which can reduce performance. In this paper, we introduce the novel concept of Graph Convolutional Networks (GCN) for brain analysis in populations, combining imaging and non-imaging data. We represent populations as a sparse graph where its vertices are associated with image-based feature vectors and the edges encode phenotypic information. This structure was used to train a GCN model on partially labelled graphs, aiming to infer the classes of unlabelled nodes from the node features and pairwise associations between subjects. We demonstrate the potential of the method on the challenging ADNI and ABIDE databases, as a proof of concept of the benefit from integrating contextual information in classification tasks. This has a clear impact on the quality of the predictions, leading to 69.5% accuracy for ABIDE (outperforming the current state of the art of 66.8%) and 77% for ADNI for prediction of MCI conversion, significantly outperforming standard linear classifiers where only individual features are considered.Comment: International Conference on Medical Image Computing and Computer-Assisted Interventions (MICCAI) 201

    Linear models of activation cascades: analytical solutions and coarse-graining of delayed signal transduction

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    Cellular signal transduction usually involves activation cascades, the sequential activation of a series of proteins following the reception of an input signal. Here we study the classic model of weakly activated cascades and obtain analytical solutions for a variety of inputs. We show that in the special but important case of optimal-gain cascades (i.e., when the deactivation rates are identical) the downstream output of the cascade can be represented exactly as a lumped nonlinear module containing an incomplete gamma function with real parameters that depend on the rates and length of the cascade, as well as parameters of the input signal. The expressions obtained can be applied to the non-identical case when the deactivation rates are random to capture the variability in the cascade outputs. We also show that cascades can be rearranged so that blocks with similar rates can be lumped and represented through our nonlinear modules. Our results can be used both to represent cascades in computational models of differential equations and to fit data efficiently, by reducing the number of equations and parameters involved. In particular, the length of the cascade appears as a real-valued parameter and can thus be fitted in the same manner as Hill coefficients. Finally, we show how the obtained nonlinear modules can be used instead of delay differential equations to model delays in signal transduction.Comment: 18 pages, 7 figure

    Histological and immunological correlates of suspected leprosy lesions

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    Thirty-two subjects with suspected leprosy lesions were investigated to assess various modalities of sensibility and sweatfunction and these were correlated with immunological and histological parameters. It was found that pain and temperature, mediated by small unmyelinated fibres were impaired in the early lesions. Impairment of sweat function was seen only when one of the modalities of sensibility was also affected Antibodies specific to a protein (35 kDa) antigen and phenolic glycolipid 1 of Mycobacterium leprae were positive in nine and 12 cases respectively, while 15 of the 31 biopsies revealed the presence of mycobacterial antigens in these lesions. The implications of these findings are discussed

    NETWORK FLOW WITH FUZZY ARC LENGTHS USING HAAR RANKING

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    ABSTRACT Shortest path problem is a classical and the most widely studied phenomenon in combinatorial optimization. In a classical shortest path problem, the distance of the arcs between different nodes of a network are assumed to be certain. In some uncertain situations, the distance will be calculated as a fuzzy number depending on the number of parameters considered. This article proposes a new approach based on Haar ranking of fuzzy numbers to find the shortest path between nodes of a given network. The combination of Haar ranking and the well-known Dijkstra's algorithm for finding the shortest path have been used to identify the shortest path between given nodes of a network. The numerical examples ensure the feasibility and validity of the proposed method

    Cosmological models with bulk viscosity in presence of adiabatic matter creation and with G, c and Lambda variables

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    Some properties of cosmological models with a time variable bulk viscous coefficient in presence of adiabatic mater creation and G, c, Lambda variables are investigated in the framework of flat FRW line element. We trivially find a set of solutions through Dimensional Analysis. In all the studied cases it is found that the behaviour of these constants is inversely prportional to the cosmic time.Comment: 12 pages. We have been rewriting and completing the bibliography of this paper. Submitted to General Relativity and Gravitatio

    Nonlinear spinor field in Bianchi type-I Universe filled with viscous fluid: numerical solutions

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    We consider a system of nonlinear spinor and a Bianchi type I gravitational fields in presence of viscous fluid. The nonlinear term in the spinor field Lagrangian is chosen to be λF\lambda F, with λ\lambda being a self-coupling constant and FF being a function of the invariants II an JJ constructed from bilinear spinor forms SS and PP. Self-consistent solutions to the spinor and BI gravitational field equations are obtained in terms of τ\tau, where τ\tau is the volume scale of BI universe. System of equations for τ\tau and \ve, where \ve is the energy of the viscous fluid, is deduced. This system is solved numerically for some special cases.Comment: 15 pages, 4 figure
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