A Survey of the Galactic Plane for 6.7-GHz Methanol Masers I: l = 325.0 - 335.0 ; b = -0.53 - 0.53

We report the results of the first complete survey of an area of the Galactic Plane for maser emission from the 6.7-GHz transition of methanol. The survey covers a 10.6-square-degree region of the Galactic Plane in the longitude range 325-335 degrees and latitude range -0.53-0.53 degrees. The survey is sensitive to masers with a peak flux density greater than approximately 2.6 Jy. The weakest maser detected has a peak flux density of 2.3 Jy and the strongest a peak flux density of 425 Jy. We detected a total of 50 distinct masers, 26 of which are new detections. We show that many 6.7-GHz methanol masers are not associated with IRAS sources, and that some are associated with sources that have colours differing from those of a typical ultra-compact HII region (UCHII). We estimate that the number of UCHII regions in the Galaxy is significantly more than suggested by IRAS-based estimates, possibly by more than a factor of two.Comment: 19 pages including 4 figures, using LaTeX formatted with mn.sty, accepted for publication in MNRA

Rapid Determination of Manganese by Differential Pulse and Alternating Current (1st harmonic) Polarography

85-8

CP-Violation For B→Xsl+l−B \to X_sl^+l^- Including Long-Distance Effects

We consider the CP violating effect for $B\to X_sl^+l^-$ process, including both short and long distance effects. We obtain the CP asymmetry parameter and present its variation over the dilepton mass.Comment: 9 pages, Latex file, one figure include

Antioxidant and antihyperglycemic potential of methanolic extract of bark of mimusops elengi l. In mice

Ayurveda refers Mimusops elengi L. for the treatment of the diabetes. Considering the traditional claim of M. elengi in management of diabetes and the possible involvement of oxidative stress in pathogenesis of diabetes, the present study was aimed to evaluate the in vitro antioxidant and in vivo antihyperglycemic property of methanolic extract of bark of M. elengi (MEMeOH). In vitro antioxidant activity of MEMeOH was evaluated using reducing power assay, DPPH and hydroxyl radical scavenging assay. MEMeOH offered significant in vitro reducing power capacity and radical scavenging activity. In acute study in alloxan induced diabetes, MEMeOH exhibited significant (p< 0.001) antihyperglycemic effect. The onset of antihyperglycemic effect was observed at 2nd hr; peak activity was demonstrated at 6th hr. The antihyperglycemic effect of MEMeOH 400mg/kg, p.o. was persistent up to 24th hr after drug administration. MEMeOH produced significant (p < 0.01) reduction in elevated glucose levels in glucose loaded non diabetic animals. The onset of action in non diabetic oral glucose tolerance test was found to be at 60th min and peak activity was observed at 120th min after oral glucose load. MEMeOH demonstrated significant (p < 0.01) reduction in elevated glucose levels 2hr before glucose administration and 6 hr after glucose load in oral glucose tolerance test in diabetic animals. MEMeOH has demonstrated antihyperglycemic activity in diabetic as well as non diabetic glucose loaded mice. MEMeOH should be further explored against diabetes and related complications.Keywords: Mimusops elengi; antihyperglycemic, antioxidant, DPPH, diabetic OGT

Bitter taste receptor agonists alter mitochondrial function and induce autophagy in airway smooth muscle cells

© 2017 the American Physiological Society. Airway remodeling, including increased airway smooth muscle (ASM) mass, is a hallmark feature of asthma and COPD. We previously identified the expression of bitter taste receptors (TAS2Rs) on human ASM cells and demonstrated that known TAS2R agonists could promote ASM relaxation and bronchodilation and inhibit mitogen-induced ASM growth. In this study, we explored cellular mechanisms mediating the antimitogenic effect of TAS2R agonists on human ASM cells. Pretreatment of ASM cells with TAS2R agonists chloroquine and quinine resulted in inhibition of cell survival, which was largely reversed by bafilomycin A1, an autophagy inhibitor. Transmission electron microscope studies demonstrated the presence of double-membrane autophagosomes and deformed mitochondria. In ASM cells, TAS2R agonists decreased mitochondrial membrane potential and increased mitochondrial ROS and mitochondrial fragmentation. Inhibiting dynamin-like protein 1 (DLP1) reversed TAS2R agonist-induced mitochondrial membrane potential change and attenuated mitochondrial fragmentation and cell death. Furthermore, the expression of mitochondrial protein BCL2/ adenovirus E1B 19-kDa protein-interacting protein 3 (Bnip3) and mitochondrial localization of DLP1 were significantly upregulated by TAS2R agonists. More importantly, inhibiting Bnip3 mitochondrial localization by dominant-negative Bnip3 significantly attenuated cell death induced by TAS2R agonist. Collectively the TAS2R agonists chloroquine and quinine modulate mitochondrial structure and function, resulting in ASM cell death. Furthermore, Bnip3 plays a central role in TAS2R agonist-induced ASM functional changes via a mitochondrial pathway. These findings further establish the cellular mechanisms of antimitogenic effects of TAS2R agonists and identify a novel class of receptors and pathways that can be targeted to mitigate airway remodeling as well as bronchoconstriction in obstructive airway diseases

Bow Shocks from Neutron Stars: Scaling Laws and HST Observations of the Guitar Nebula

The interaction of high-velocity neutron stars with the interstellar medium produces bow shock nebulae, where the relativistic neutron star wind is confined by ram pressure. We present multi-wavelength observations of the Guitar Nebula, including narrow-band H-alpha imaging with HST/WFPC2, which resolves the head of the bow shock. The HST observations are used to fit for the inclination of the pulsar velocity vector to the line of sight, and to determine the combination of spindown energy loss, velocity, and ambient density that sets the scale of the bow shock. We find that the velocity vector is most likely in the plane of the sky. We use the Guitar Nebula and other observed neutron star bow shocks to test scaling laws for their size and H-alpha emission, discuss their prevalence, and present criteria for their detectability in targeted searches. The set of H-alpha bow shocks shows remarkable consistency, in spite of the expected variation in ambient densities and orientations. Together, they support the assumption that a pulsar's spindown energy losses are carried away by a relativistic wind that is indistinguishable from being isotropic. Comparison of H-alpha bow shocks with X-ray and nonthermal, radio-synchrotron bow shocks produced by neutron stars indicates that the overall shape and scaling is consistent with the same physics. It also appears that nonthermal radio emission and H-alpha emission are mutually exclusive in the known objects and perhaps in all objects.Comment: 12 pages, 7 figures (3 degraded), submitted to ApJ; minor revisions and updates in response to referee report. (AASTeX, includes emulateapj5 and onecolfloat5.

Texture of fermion mass matrices in partially unified theories

We investigate the texture of fermion mass matrices in theories with partial unification (for example $SU(2)_L\times SU(2)_R\times SU(4)_c$) at a scale $\sim 10^{12}$ GeV. Starting with the low energy values of the masses and the mixing angles, we find only two viable textures with atmost four texture zeros. One of these corresponds to a somewhat modified Fritzsch textures. A theoretical derivataion of these textures leads to new interesting relations among the masses and the mixing angles.Comment: 10 pages(Latex

Dielectric characterization and molecular interaction behaviour in binary mixtures of methyl acetate with 1-butanol and 1-pentanol

900-910The dielectric constant (ɛs) and relaxation time () of binary mixtures of methyl acetate with alcohols (1-butanol and 1-pentanol) have been investigated at fifteen molar concentrations over the entire mixing range at 288 K, 298 K, 308 K and 318 K using time domain reflectometery technique over the frequency range from 10 MHz to 10 GHz. The relaxation in these mixtures can be described by a single relaxation time using the Debye model. The concentration dependent plots of excess dielectric constant (ɛE), excess inverse relaxation time (1/)E, Kirkwood correlation factor (geff), thermodynamic parameters such as enthalpy of activation (H) and Gibbs free energy (G) of activation and Bruggman factor (fB) have been used to explore the complexes formed between unlike molecules, dipolar ordering, hydrogen bond molecular connectivity’s and their strength in the binary mixtures. Results confirm that there are strong hydrogen-bond interactions between unlike molecules of ester-alcohol mixtures