Rifaximin for the treatment of acute infectious diarrhea

Rifaximin is a nonabsorbable rifamycin derivative with an excellent safety profile and a broad spectrum of antimicrobial activity against a variety of enteropathogens causing acute infectious diarrhea. After oral ingestion, its bioavailability is known to be less than 0.4%, and it has a low potential for significant drug interactions. In the treatment of travelers’ diarrhea caused by noninvasive diarrheagenic Escherichia coli, it has been demonstrated that rifaximin significantly shortens the duration of diarrhea and has an efficacy similar to that of ciprofloxacin. Moreover, according to two randomized placebo-controlled trials, prophylactic treatment with rifaximin reduced the risk of developing travelers’ diarrhea by more than 50% compared with the placebo group. For the treatment of acute diarrhea unrelated to travel, a short course of rifaximin significantly reduced the duration of diarrhea, and its overall efficacy was comparable to that of ciprofloxacin. The discrepancy between the in vitro and in vivoantimicrobial activities of rifaximin, however, and the clinical implication of the rapid appearance of bacterial resistance, must be further elucidated. In conclusion, this gut-selective antibiotic seems to be a promising option for the treatment of acute infectious diarrhea secondary to noninvasive E. coli and also appears to be effective in chemoprophylaxis for travelers’ diarrhea

The Experience of Chamwino Small-Scale Farmers on the Use of Smartphone in Farming Business, Tanzania

Part 2: Digital Platforms for DevelopmentInternational audienceThe pervasive use of smartphones to acquire diverse information among small-scale farmers has received little attention in studies. This study, therefore, explored the experience of Chamwino’s small-scale farmers of the usage of smartphone to address ownership pattern, farming practices, information needs, encountered challenges and training needs for future technological alterations. The study employed qualitative design for data collection and thematic analysis was used. The findings revealed that the longer the distance from Dodoma city centre, the fewer the number of smartphones owners. That, less than half of farmers in Mvumi and Makangwa owned smartphones while, less than a quarter in Itiso, Mpwayungu, and Chilonwa Divisions. That youths owned more smartphones than elders, and mostly second-hand that were inadequately used for farming business. This was because, there was no special farming enabled information system to disseminate agricultural information. Accordingly, the frequently used features were SMS and voice calls. Consequently, farmers need information on inputs, weather, market and finance among others. Alternatively, there was no official training on the use of the device thus the new technology was therefore underutilized. Furthermore, challenges identified were farmers’ lack of expertise of utilizing the device, uncomfortable large size and the interface of smartphones. Accordingly, farmers were interested in capacity building as many features were not used adequately. Consequently, the study provides deep understanding of farmers’ experience and recommends for technological alteration to increase usability of the device