Psöriazis vulgaris hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı, ortalama trombosit hacmi ve C-reaktif protein değerleri

Amaç: Son yıllarda nötrofil/lenfosit oranı (NLO), trombosit/lenfosit oranı (TLO),ortalama trombosit hacmi(OTH) ve C reaktif protein(CRP)’nin sistemik inflamasyonun önemli göstergeleri olduğu gösterilmiştir. Yapılan çalışmalarda psöriazis vulgaris hastalarında NLO, TLO, OTH ve CRP ’nin kontrol gurubuna göre daha yüksek olduğu gösterilmiştir. Çalışmamızda psöriazisli hastaların NLO, TLO, OTH ve CRP düzeyleri ölçüldü ve bu parametrelerin tırnak tutulumu, artrit varlığı, hastalık süresi ve PAŞİ skoru ile ilişkili olup olmadığı araştırıldı. Yöntemler: Herhangi bir sistemik hastalığı, infeksiyöz hastalığı ve otoimmun hastalığı olmayan 133 psöriazis vulgaris hastası ve 107 sağlıklı kontrol çalışmaya dahil edildi. Hastalar PAŞİ skoruna göre hafif (PAŞİ<10) ve orta-şiddetli (PAŞİ≥10) olarak 2 gruba ayrıldı. Bulgular: Hasta grubundaki NLO, OTH ve CRP kontrol grubuna göre anlamlı olarak yüksek idi. (sırasıyla p=0.001, p=0.003, p<0.001). Hasta grubundaki TLO değeri, kontrol grubuna kıyasla düşük olmakla beraber aralarındaki fark istatistiksel olarak anlamlı değildi. (p:0,074) Psöriazisli hastalar arasında, OTH ve CRP değerleri orta-şiddetli grupta, hafif gruba göre yüksekti ve aradaki fark istatistiksel olarak anlamlıydı. (sırasıyla p:0,017, p<0.001). OTH ve CRP değerleri ile artrit varlığı, tırnak tutulumu ve hastalık süresi arasında istatistiksel olarak anlamlı bir ilişki saptanmadı. (p>0.05) NLO ve TLO değerleri ile PAŞİ skoru, artrit varlığı, tırnak tutulumu ve hastalık süresi arasında istatistiksel olarak anlamlı bir ilişki saptanmadı. (p>0.05) Sonuç: NLO ve CRP’ nin psöriazis hastalarında inflamasyonu göstermede uygun bir parametre olduğu söylenebilir bununla birlikte NLO’ nun hastalık şiddetiyle korele olmaması klinik kullanımını kısıtlayabilir. OTH’ nın psöriazis hastalarında kontrollere göre daha yüksek olması ve PAŞİ skoru ile ilişkili olması inflamasyon belirteci olarak kullanılmasının TLO ve NLO’ ya kıyasla daha yararlı bir belirteç olduğunu göstermektedir

Clinical examination and demographic characteristics of 277 patients with psoriasis

Background and Design: This study aimed to prospectively evaluate the clinical and demographic characteristics of patients with psoriasis. Materials and Methods: This study included a total of 277 patients with psoriasis who applied to our clinic between December 2018 and February 2020. All patient parameters such as age, sex, height, weight, marital status, age at disease onset, triggering factors, joint and nail involvement, systemic disease history, alcohol and smoking history, family history, and topical and systemic treatments received were recorded prospectively. Statistical analysis was conducted using the SPSS version 24. Results: The mean age of the 277 patients aged 8-81 years was 37.1+-15.9 years. In this study, 125 (45.1%) patients were female and 152 (54.9%) were male, and 11.2% of the patients were &lt;18 years old. Ten of the patients with pediatric psoriasis were male and 21 were female. The mean age at disease onset was 21.0+-14.1 in female patients and 25.3+-14.4 in male patients. The most common clinical type was plaque psoriasis. Family history was positive in 29.6% of the patients. Psoriatic arthritis occurred in 9% of the patients, and the most common type was an asymmetric oligoarticular type. Although the nail involvement rate was 44%, stress was the most common triggering factor for psoriasis. In addition, 17% of the patients had a comorbid disease. The most common comorbid disease was hypertension. The frequency of smoking was 45.8%, and the frequency of alcohol use was 4.7%. Of the patients, 17.3% received only topical therapy; 1.1%, phototherapy; 37.5%, conventional therapy; 42.2%, biological therapy; and 1.8%, conventional + biological therapy. Conclusion: Our study data were similar to those of other studies examining the clinical and demographic characteristics of patients with psoriasis. We believe that conducting similar studies involving larger patient groups will contribute to disease diagnosis and treatment

A Rare Case of Facial Steatocystoma Multiplex

Abstract Steatocystoma multiplex (SM) is a rare hereditary condition of the skin that manifests with multiple cystic lesions. Most commonly, it occurs during adolescence and early adulthood when the sebaceous activity peaks. The lesions are mostly observed on the trunk, neck, arms, axilla, groins and scalp where the pilosebaceous activity is intense. This condition may involve the face together with the body; however, predominant or isolated involvement of the face represents a rare condition. This case is presented as it was interesting, considering the age of the patient and the rare localization.  </p

Patient use of complementary and alternative medicine for psoriasis vulgaris and factors believed to trigger the disease: A multicenter cross-sectional study with 1621 patients

Introduction: Due to the chronic recurrent nature of psoriasis vulgaris (PV) and lack of definitive treatment for the disease, patients often resort to alternative treatments. Physicians seem to have low awareness of this issue. Objectives: To elicit the perceptions of 1,621 PV patients on complementary and alternative medicine (CAM) and examine factors reported to worsen PV. Methods: The patients sociodemographic characteristics, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), disease duration, and severity were recorded, and the patients CAM use was questioned in detail. The patients were also asked about factors that worsened PV and their experiences with a gluten-free diet. Results: Of the patients, 56.51% had used CAM. The mean age, illness duration, PASI scores and DLQI of those using CAM were significantly higher. CAM use was significantly higher in those with facial, genital involvement, and arthralgia/arthritis. The patients mostly referred to CAM when PV became severe (46.4%). Of the CAM users, 45.52% used herbal topicals. The physicians of 67.03% did not inquire whether they used CAM. Of the participants, 37.73% considered that stress worsened their disease. Gluten-free diet did not affect PV symptoms in 52.22%. Conclusions: Patients CAM use is often overlooked by dermatologists. Our results showed that more than half the patients used CAM and did not share this information with their physicians. Therefore, the awareness of physicians should be increased and patients should be asked about the use of CAM and directed to the appropriate medical treatment options by physicians

Habits of using social media and the internet in psoriasis patients

Introduction: Psoriasis significantly affects the patients quality of life, which often leads patients to seek online information about this disease. Objectives: To explore the habits of patients with psoriasis related to their use of social media (SM) and the internet to obtain information about their disease. Methods: 1,520 patients completed the survey and the Dermatology Life Quality Index (DLQI) questionnaire. The Psoriasis Area Severity Index scores (PASI) and clinical data of the patients were recorded by their physicians. Results: Of the 1,114 patients that reported using SM and internet, 48.38% regularly and 31.14% sometimes resorted to obtain information about psoriasis. The use of SM and internet for psoriasis was statistically significantly higher among young people (P = 0.000), those with university or higher education (P = 0.009), higher DLQI (P = 0.000) and PASI (P = 0.011) scores, facial (P = 0.050), scalp (P = 0.032), hand (P = 0.048), genital (P = 0.001) and inverse (P = 0.000) involvement, and arthralgia/arthritis (P = 0.006). The participants mostly used the Google (86%) and Facebook (41%). More than half of the participants (62.8%) expected dermatologists to inform society that psoriasis is not contagious. Conclusions: Internet and SM being widely available and offering substantial information to be easily accessed make it very attractive for patients to use these platforms to investigate diseases, including psoriasis. If what is presented on SM conflicts with what the physician says, patients mostly trust the latter, but at the same time, they tend not to share the results of their online inquiries with their physicians

Plaque with asymptomatic verrucous surface on the right leg: Dermatofibroma

Dermatofibroma is a benign fibrohistiocytic neoplasia. The etiology of dermatofibroma remains uncertain but it is considered to have a traumatic origin such as an insect bite or follicular rupture. Dermatofibroma clinically presents as smooth-surface nodular lesions. We report a patient with a plaque with asymptomatic verrucous surface on the right leg

Psoriasis and concomitant diseases

Psoriazis kronik inflamatuar bir hastalıktır. Psoriazis ile ilgili yapılan çalışmalarda bu inflamatuar durumun klinik yansımasının artık deriye sınırlı olmadığı, eşlik eden bazı inflamatuar hastalıkların psoriaziste normalde beklenenden farklı sayıda olduğu fark edilmiştir. Psoriazisle ilişkili eskiden beri bilinen depresyon ve yaşam kalitesi, psoriatik artrit, malignensi gibi bazı komorbiditelere ek olarak kardiovasküler hastalık, metabolik sendrom, inflamatuar barsak hastalıkları, uyku apne sendromu gibi yeni araş- tırılan komorbiditeler tanımlanmıştır. Bu derlemede sık görülen komorbiditelerin ve konu ile alakalı yapılmış çalışmalardan bahsedilecektir.Psoriasis is a chronic inflammatory disease. It has been noticed in the studies on psoriasis that the clinical reflection of this inflammatory condition is not limited to the skin any more and the number of some concomitant inflammatory diseases in psoriasis is higher than expected. Newly studied comorbidities such as cardiovascular disease, metabolic syndrome, ınflammatory bowel diseases, sleep apnea syndrome have been defined in addition to depression and quality of life, psoriatic arthritis, malignancy that have long been known to be associated with psoriasis. In this review, common comorbidities and the relevant studies in the literature are presented

Psoriasis and concomitant diseases

Psoriazis kronik inflamatuar bir hastalıktır. Psoriazis ile ilgili yapılan çalışmalarda bu inflamatuar durumun klinik yansımasının artık deriye sınırlı olmadığı, eşlik eden bazı inflamatuar hastalıkların psoriaziste normalde beklenenden farklı sayıda olduğu fark edilmiştir. Psoriazisle ilişkili eskiden beri bilinen depresyon ve yaşam kalitesi, psoriatik artrit, malignensi gibi bazı komorbiditelere ek olarak kardiovasküler hastalık, metabolik sendrom, inflamatuar barsak hastalıkları, uyku apne sendromu gibi yeni araş- tırılan komorbiditeler tanımlanmıştır. Bu derlemede sık görülen komorbiditelerin ve konu ile alakalı yapılmış çalışmalardan bahsedilecektir.Psoriasis is a chronic inflammatory disease. It has been noticed in the studies on psoriasis that the clinical reflection of this inflammatory condition is not limited to the skin any more and the number of some concomitant inflammatory diseases in psoriasis is higher than expected. Newly studied comorbidities such as cardiovascular disease, metabolic syndrome, ınflammatory bowel diseases, sleep apnea syndrome have been defined in addition to depression and quality of life, psoriatic arthritis, malignancy that have long been known to be associated with psoriasis. In this review, common comorbidities and the relevant studies in the literature are presented