39 research outputs found
Caching at the edge in high energy-efficient wireless access networks
In the next generation of Radio Access Networks (RANs), Multi-access Edge Computing (MEC) is considered a promising solution to reduce the latency and the traffic load of backhaul links. It consists of the placement of servers, which provide computing platforms and storage, directly at each Base Station (BS) of these networks. In this paper, the caching feature of this paradigm is considered in a portion of a RAN, powered by a renewable energy generator system, energy batteries and the power grid. The performance of the caching in the RAN is analysed for different traffic characteristics, as well as for different capacity of the caches and different spread of it. Finally, we verify that the usage of a strategy that aims at reducing the energy consumption does not impact the benefits provided by the mobile edge caching
5G and beyond networks
This chapter investigates the Network Layer aspects that will characterize the merger of the cellular paradigm and the IoT architectures, in the context of the evolution towards 5G-and-beyond, including some promising emerging services as Unmanned Aerial Vehicles or Base Stations, and V2X communications
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
Background A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies.Methods We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3871) in men of European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. We used grouped relative risk models to test associations with approximately 6 million genotyped or imputed variants (time to first grade 2 or higher toxicity event). Variants with two-sided Pmeta less than 5 × 10-8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided.Results Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism rs17055178 with rectal bleeding (Pmeta = 6.2 × 10-10), rs10969913 with decreased urinary stream (Pmeta = 2.9 × 10-10), and rs11122573 with hematuria (Pmeta = 1.8 × 10-8). Fine-scale mapping of these three regions was used to identify another independent signal (rs147121532) associated with hematuria (Pconditional = 4.7 × 10-6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts.Conclusions This study increases the understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multinational radiogenomics studies in larger cohorts are worthwhile
Модель професійної культури юриста: критерії та підходи
В статті визначається модель професійної культури