1 research outputs found
Enzyme inhibitory assessment of the isolated constituents from Plantago holosteum Scop.
Plants of the Plantago genus are widely used in Turkish folk medicine
especially for the treatment of wound, abscess, and inflammation. The
aqueous extract and five phenylethanoid glycosides acteoside (1),
arenarioside (2), echinacoside (3), isoacteoside (4), and
leucosceptoside A (5) isolated from the aerial parts and roots of
Plantago holosteum Scop. (Plantaginaceae) were tested for their possible
inhibitory activity against hyaluronidase, elastase, and collagenase,
related to wound pathogenesis. Even though the aqueous extract prepared
from the aerial parts (36.26\%) and roots (47.01\%) and the isolated
compounds acteoside (29.13\%), echinacoside (28.73\%), and isoacteoside
(31.69\%) exerted a notable inhibition, arenarioside and leucosceptoside
A were found inactive in the hyaluronidase enzyme inhibition test.
Similar results were obtained from the collagenase enzyme inhibition
test. The aqueous extract prepared from the aerial parts (31.09\%) and
roots (35.17\%), echinacoside (25.13\%), and isoacteoside (23.85\%)
exerted a notable inhibition in this test. However, none of the extracts
and isolated compounds displayed elastase enzyme inhibitory activity.
The experimental data demonstrated that P. holosteum displayed a
remarkable enzyme inhibitory activity against hyaluronidase and
collagenase. This paper is the first report regarding the in vitro
enzyme inhibitory activity of P. holosteum