Blocking TGF-β signaling pathway preserves mitochondrial proteostasis and reduces early activation of PDGFRβ+ pericytes in aristolochic acid induced acute kidney injury in wistar male rats

The platelet-derived growth factor receptor β (PDGFRβ)+ perivascular cell activation becomes increasingly recognized as a main source of scar-associated kidney myofibroblasts and recently emerged as a new cellular therapeutic target.In this regard, we first confirmed the presence of PDGFRβ+ perivascular cells in a human case of end-stage aristolochic acid nephropathy (AAN) and thereafter we focused on the early fibrosis events of transforming growth factor β (TGFβ) inhibition in a rat model of AAN.Neutralizing anti-TGFβ antibody (1D11) and its control isotype (13C4) were administered (5 mg/kg, i.p.) at Days -1, 0, 2 and 4; AA (15 mg/kg, sc) was injected daily.At Day 5, 1D11 significantly suppressed p-Smad2/3 signaling pathway improving renal function impairment, reduced the score of acute tubular necrosis, peritubular capillaritis, interstitial inflammation and neoangiogenesis. 1D11 markedly decreased interstitial edema, disruption of tubular basement membrane loss of brush border, cytoplasmic edema and organelle ultrastructure alterations (mitochondrial disruption and endoplasmic reticulum edema) in proximal tubular epithelial cells. Moreover, 1D11 significantly inhibited p-PERK activation and attenuated dysregulation of unfolded protein response (UPR) pathways, endoplasmic reticulum and mitochondrial proteostasis in vivo and in vitro.The early inhibition of p-Smad2/3 signaling pathway improved acute renal function impairment, partially prevented epithelial-endothelial axis activation by maintaining PTEC proteostasis and reduced early PDGFRβ+ pericytes-derived myofibroblasts accumulation

Osteoarticular amyloidosis associated with hemodialysis: an immuno-ultrastructural study

Osteoarticular amyloidosis occurred in a patient receiving long term haemodialysis. Histological examination showed that the amyloid deposit was surrounded by inflammatory cells and macrophages filled with haemosiderin. Electron microscopy showed that the amyloid fibrils were in close contact with cytoplasmic expansions, or located in intracytoplasmic pockets of the infiltrating cells. Immunohistological and immunoultrastructural observations confirmed that beta 2-microglobulin was a major constituent of amyloidosis associated with dialysis. Amyloid P component was also detected within the amyloid deposits. These findings suggest that amyloid P component, iron overload, or macrophage derived factors could have a role in the polymerisation of beta 2-microglobulin into amyloid deposit.Case ReportsJournal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Use of Biopty gun for corpus cavernosum biopsies

Needle biopsy of the corpus cavernosum with the Biopty gun system has been performed in impotent patients. This technique is cost-effective, rapid, safe, relatively harmeless and effective in obtaining erectile tissue to identify the presence of intracavernous structures (smooth muscle cells, collagen, arteries and nerves). It can certainly replace the open method, but we have to determine its place in the assessment of impotent patients.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

HYDROCEPHALIE PROVOQUEE PAR UN ANEVRYSME GEANT DE L'ARTERE BASILAIRE

In the light of the literature, the authors discuss the case of a 66 yr-old hypertensive patient presenting headaches, disorders of gait and deglutition, dysphonia and urinary incontinence. A CAT scan showed dilatation of the entire ventricular system. Anatomo-pathological investigation showed a voluminous bisaccular aneurysmal malformation in the basilar artery. By deforming the pons and the medulla oblongata, the aneurysm had compressed the fourth ventricle and cerebral aqueduct, thus causing hydrocephalus.SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Acute renal insufficiency after colon cleansing.

Case ReportsJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Phytothérapie et néphrotoxicité

info:eu-repo/semantics/publishe

Cylindrome de la base du crâne à manifestations neurologiques de longue durée. Corrélation anatomo-clinique

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Acute interstitial nephritis with nephrotic syndrome after intake of naproxen and amoxicillin (letter)

info:eu-repo/semantics/publishe

CONFRONTATIONS TOMODENSITOMETRIE - ANATOMO-PATHOLOGIE. FIABILITE DE LA DETECTION DE LESIONS ISCHEMIQUES AU NIVEAU DU TRONC CEREBRAL PAR EXAMEN TOMODENSITOMETRIQUE

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Tumeur du cavum inhabituelle dans nos régions à propos d'un cas de rhinosporidiose

Rhinosporidiosis is an ailment of the mucous membranes provoked by a microorganism described by Seeber in 1900. It is found in Africa, South America, India, Ceylon, Philipines and Iran. Rhinosporidium Seeberi provokes the appearance of sessile polyps, friable on the mucous membranes. The nasal mucous membrane is affected in 72% of the cases. The symptoms in otorhinolaryngology are in most cases mucous or mucopurulent rhinorrhea, chronic epistaxis and a progressive nasal obstruction. The etiologic diagnosis is based on clinical examination, on the examination of rhinorrhea and especially on histopathological examination. In case of lesions at the nasopharynx level rhinosporidiosis must be differentiated from inflammatory or parasitic lesions, from embryonic or malignant tumours. Prognosis is generally favourable; the treatment is mainly surgical.SCOPUS: ar.jinfo:eu-repo/semantics/publishe