1 research outputs found
Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing
Injectable
scaffolds are of great interests for skin regeneration
because they can fill irregularly shaped defects through minimally
invasive surgical treatments. In this study, an injectable hydrogel
from biopolymers is developed and its application as wound dressings
is examined. Gelatin-based hydrogels were successfully prepared at
body temperature upon blending with low content of gellan, and the
synergetic effect on the gel formation was carefully characterized
through rheological methods. The electrostatic complexation between
gelatin and gellan was confirmed to contribute a continuous hydrogel
network. The obtained blend hydrogel demonstrates remarkable shear-thinning
and self-recovering properties. For antibacterial purpose, tannic
acid was incorporated into the blend hydrogel. In addition, tannic
acid-loaded blend hydrogel was verified to accelerate the wound healing
on the mice model, significantly than the control groups. Thus, this
paper presents a facile approach without chemical modification to
construct injectable gelatin-based hydrogels, which have great potential
as a wound dressing or tissue scaffold at body temperature