NANOPARTICLE: AS TARGETED DRUG DELIVERY SYSTEM FOR DEPRESSION

Nanoparticles (NP) are defined as particles with a diameter smaller than 100 nm, are increasingly used in different applications, including drug carrier systems and to pass organ barriers such as the blood-brain barrier. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Different methods containing various polymers are used for formulation of nanoparticle to increase therapeutic benefit, while minimizing side effect for drug delivery research. While benefits of nanotechnology are widely publicised, the discussion of the potential effects of their widespread use in the consumer and industrial products are just beginning to emerge. This review provides comprehensive analysis of data available on health effects of nanomaterials

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Not AvailableIn the present investigation, 17 accessions of Vitis sp. were characterized based on morphological traits and microsatellite markers at ICAR-National Research Center for Grapes, Manjri Farm, Pune during the year 2014-15. Total 21 phenological characters were considered for morphological characterization. Among these, all quantitative traits such as : bunch weight, bunch length, pedicel length, berry length, berry diameter, berry weight, seed weight, titrable acidity, pH and total soluble solids (TSS) showed significant differences among varieties. Red Globe scored highest in terms of yield related parameters such as bunch weight, berry length, berry diameter and 10-berry weight. The molecular data collected from five microsatellite markers produced total 25 DNA fragments. Highest polymorphism was shown by the microsatellite marker VVMD 7 with polymorhic information content (PIC) value 0.80 followed by the VrZag 79 (PIC value : 0.71). Highest allelic diversity (0.82) was observed in VVMD 7. Significant differences were recorded among the accessions with respect to individual microsatellite marker.Not Availabl

Esculentins A & B, two new diterpenes from <i>Casearia esculenta</i>

2706-2708The structures of esculentins A and B, isolated from the twigs of Casearia esculenta (Samydaceae), have been elucidated. They are found to be 18β,19β-diacetyloxy-18α, 19α-epoxy- 3, 13(16), 14-clerodatrien-2-one 1 and 18β, 19β-diacetyloxy-18α, 19α-epoxy-3,12,14- clerodatrien-2β-isovaleryloxy-6β,7α-diol 2 respectively by the analysis of 1D- and 2D-NMR spectra. Both 1 and 2 show weak cytokine inhibition activity

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Not AvailableSixteen grape varieties were characterized based on twenty-seven ampelographic traits and five microsatellite markers as per OIV descriptors at ICAR-National Research Centre for Grapes, Pune (INDIA). Variety, Champanel and Manjari Naveen displayed loose bunch compactness. White Sweet and Christmas Rose recorded with firm berry attachment with pedicel. Using principle component analysis, first three component described 50% variation. Highly significant differences were exhibited by all quantitative traits. White Sweet variety exceled in terms of traits like bunch weight (510.00±17.93g),berry length (24.57±0.60mm) and berry diameter (21.53±0.95mm).Maximum bunch length (21.64±0.62mm),10 berry weight (45.04±1.14gm) and total soluble solids (23.77±1.03oB) was recorded in Crimson Seedless, Maroo Seedless and Centennial Seedless respectively. Among sixteen varieties, seven were seeded (Champanel, White Sweet, Angoor Kalan, Spin Sahebi, JaosBelyi, Black Round and Christmas Rose). Five microsatellite markers had shown 55% of allelic diversity among the varieties based on 24 alleles generated. Marker VrZag79 had displayed maximum allelic diversity (75.78%).Total three clusters were generated in the dendrogram, where Black Round and Centennial Seedless were classified individually in two separate clusters. These information will be useful in selection of parents in breeding programme and profile generated will provide the identity to the variety.Not Availabl