40 research outputs found
Exemestane in the Adjuvant Treatment of Breast Cancer in Postmenopausal Women
Exemestane is an irreversible inhibitor of the aromatase enzyme, which is a key component in the production of estrogen. The majority of breast cancers are sensitive to the proliferative effects of estrogen. Exemestane is approved for the adjuvant treatment of postmenopausal women with breast cancer after 2 to 3 years of tamoxifen therapy, based on a 32% improvement in disease-free survival compared with 5 years of tamoxifen alone (P < 0.001). Exemestane has also shown clinical benefits as an upfront therapy. The safety profile of exemestane shares some side effects with tamoxifen (hot flashes and arthralgia), but is not associated with an increased risk of endometrial cancer or thromboembolic events. This review will discuss in detail the efficacy and safety of exemestane in early breast cancer
Searching singlet extensions of the supersymmetric standard model in orbifold compactification of heterotic string
We search for supersymmetric standard model realizations with extra singlets
and extra using the heterotic string compactification on the orbifold with two Wilson lines. We analyze the vacuum restabilization
mechanism for three representative Pati-Salam string models obtained in the
literature and present detailed results for the effective superpotential
compatible with the string selection rules. An automated selection of
semi-realistic vacua along flat directions in the non-Abelian singlet modes
field space is performed by requiring the presence of massless pairs of
electroweak Higgs bosons having trilinear superpotential couplings with
massless singlet modes and the decoupling of color triplet exotic modes needed
to suppress and number violating processes.Comment: revtex4 format, 21 pages, 7 tables, shortened version added
reference
Generalized Second Law of Thermodynamics in Gravity with Entropy Corrections
We study the generalized second law (GSL) of thermodynamics in
cosmology. We consider the universe as a closed bounded system filled with
component fluids in the thermal equilibrium with the cosmological boundary. We
use two different cosmic horizons: the future event horizon and the apparent
horizon. We show the conditions under which the GSL will be valid in specific
scenarios of the quintessence and the phantom energy dominated eras. Further we
associate two different entropies with the cosmological horizons: with a
logarithmic correction term and a power-law correction term. We also find the
conditions for the GSL to be satisfied or violated by imposing constraints on
model parameters.Comment: 17 pages, no figure, title changed, version accepted for publication
in Astrophysics and Space Scienc
Progress in Breast Cancer—Can We Do Better?
Breast cancer remains the most common malignancy diagnosed in women in North America. [...