Comparison of FFP predictions with measurements of a low-frequency signal propagated in the atmosphere

An experimental study of low-frequency propagation over a distance of 770 m was previously reported (J. Acoust. Soc. Am. Suppl. 1 86, S120 (1989)). For that study, sound speed profiles were reconstructed entirely from surface-layer micrometeorological data. When the acoustic data were compared with theoretical predictions from a fast field program (FFP), it was found that the FFP underpredicted sound levels measured in a shadow zone. Here, the effect on the predictions of including meteorological data for heights greater than the surface layer, i.e., wind profiles measured by a Doppler sodar, is discussed. Vertical structure of turbulence is simulated by stochastically perturbing the mean profiles, and the agreement between the acoustic data and FFP predictions is improved

Construction and Software Design for a Microcomputer Controlled pH/Ion Titrator

The construction of an automated titration device is described. The major components include an Apple II+ Microcomputer and 8-bit parallel interface. Fisher Accumet, Model 520 Digital pH/lon Meter, Gilmont Micrometer Buret of 2.5 mL capacity, Sigma stepper motor, power supply and driver to operate the buret, and a constant temperature bath of ± 0.005 °C stability. The limitations of the system are 0.001 pH/0.1 mv for the pH/ion sensing system, and 0.125 μL per step for the buret. The system as described is designed to determine equilibrium constants for metal ion-amino acid complexes. By changing the software a variety of different pH and redox titration experiments may be performed. A computer program used to operate the stepper motor driven syringe buret and record the pH from a digital pH meter is described. The program uses both Apple BASIC and assembly language. This is a closed loop operation in which the data from the pH meter is used to control the amount of reagent delivered by the buret. The results are displayed graphically as the titration proceeds. The variance of the pH readings are calculated using an assembly language subroutine and the calculations are done with zero round-off error

BATSE flare observations in Solar Cycle 22

The Hard X-Ray Burst Spectrometer (HXRBS) group at GSFC has developed and is maintaining a quick-look analysis system for solar flare hard x-ray data from the Burst and Transient Source Experiment (BATSE) on the recently launched Compton Gamma-Ray Observatory (GRO). The instrument consists, in part, of 8 large planar detectors, each 2025 sq cm, placed on the corners of the GRO spacecraft with the orientation of the faces being those of a regular octahedron. Although optimized for the detection of gamma-ray bursts, these detectors are far more sensitive than any previous spacecraft-borne hard x-ray flare instrumentation both for the detection of small microflares and the resolution of fine temporal structures. The data in this BATSE solar data base are from the discriminator large area (DISCLA) rates. From each of eight detectors there are hard x-ray data in four energy channels, 25-50, 50-100, 100-300, and greater than 300 keV with a time resolution of 1.024 seconds. These data are suitable for temporal correlation with data at other wavelengths, and they provide a first look into the BATSE and other GRO instrument flare data sets. The BATSE and other GRO principle investigator groups should be contacted for the availability of data sets at higher time or spectral resolution or at higher energies

The Role of Ligand Steric Bulk in New Monovalent Aluminum Compounds

The article of record as published may be located at https://doi.org/10.1021/acs.jpca.7b02075The tetrameric Al(I) cyclopentadienyl compound Al4Cp*4 (Cp* = C5Me5) is a prototypical low-valence Al compound, with delocalized bonding between four Al(I) atoms and η5 ligands bound to the cluster exterior. The synthesis of new [AlR]4 (R = C5Me4Pr, C5Me4iPr) tetramers is presented. Though these systems failed to crystallize, comparison of variable-temperature 27Al NMR data with density functional theory (DFT) calculations indicate that these are Al4R4 tetramers analogous to Al4Cp*4 but with increased ligand steric bulk. NMR, DFT, and Atoms in Molecules analyses show that these clusters are enthalpically more stable as tetramers than the Cp* variant, due in part to noncovalent interactions across the bulkier ligand groups. Thermochemistry calculations for the low-valence metal interactions were found to be extremely sensitive to the DFT methodology used; the M06-2X functional with a cc-pVTZ basis set is shown to provide very accurate values for the enthalpy of tetramerization and 27Al NMR shifts. This computational method is then used to predict geometrical structures, noncovalent ligand interactions, and monomer/tetramer equilibrium in solution for a series of Al(I) cyclopentadienyl compounds of varying steric bulk

Effect of Duplicate Isolates of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus on Antibiogram Data

This is the published version, also available here: http://www.dx.doi.org/10.1128/JCM.41.10.4611-4616.2003

Hypoxia-responsive microRNAs and trans-acting small interfering RNAs in Arabidopsis

Low-oxygen (hypoxia) stress associated with natural phenomena such as waterlogging, results in widespread transcriptome changes and a metabolic switch from aerobic respiration to anaerobic fermentation. High-throughput sequencing of small RNA libraries obtained from hypoxia-treated and control root tissue identified a total of 65 unique microRNA (miRNA) sequences from 46 families, and 14 trans-acting small interfering RNA (tasiRNA) from three families. Hypoxia resulted in changes to the abundance of 46 miRNAs from 19 families, and all three tasiRNA families. Chemical inhibition of mitochondrial respiration caused similar changes in expression in a majority of the hypoxia-responsive small RNAs analysed. Our data indicate that miRNAs and tasiRNAs play a role in gene regulation and possibly developmental responses to hypoxia, and that a major signal for these responses is likely to be dependent on mitochondrial function

Superconductivity in Cu_xTiSe_2

Charge density waves (CDWs) are periodic modulations of the conduction electron density in solids. They are collective states that arise from intrinsic instabilities often present in low dimensional electronic systems. The layered dichalcogenides are the most well-studied examples, with TiSe_2 one of the first CDW-bearing materials known. The competition between CDW and superconducting collective electronic states at low temperatures has long been held and explored, and yet no chemical system has been previously reported where finely controlled chemical tuning allows this competition to be studied in detail. Here we report how, upon controlled intercalation of TiSe_2 with Cu to yield Cu_xTiSe_2, the CDW transition is continuously suppressed, and a new superconducting state emerges near x = 0.04, with a maximum T_c of 4.15 K found at x = 0.08. Cu_xTiSe_2 thus provides the first opportunity to study the CDW to Superconductivity transition in detail through an easily-controllable chemical parameter, and will provide new insights into the behavior of correlated electron systems.Comment: Accepted to Nature Physic

The Ursinus Weekly, March 12, 1962

Nobel Prize-winner here tonight: Dr. Linus Pauling to address special forum on Science and international relations • Book No more war! Dr. Pauling\u27s credo • Local high school pupils invited to PSEA panel • UC students attend I.C.G. convention • Student-faculty talent show to finish Campus Chest charity drive Friday • College\u27s concert band to perform next Thursday • Lauderdale braces for Spring influx • Civil liberty\u27s Cox visits U.C. campus • Campus Chest activities continue this week • Ursinus invites public to use College Library • St. Pat\u27s twist theme of frosh dance Saturday • Pre-med club to see films depicting Caesarian birth • Editorial: Just this once • Penna. folk festival planned for Harrisburg • Ursinus in the past • Curtain Club offers two plays; One-act shows given last Thursday • Women\u27s hairbreadth victories mark basketball play; Sansenbach stars • High scoring continues; Intramural finish nears • Mermaids win two in week\u27s action • Sports publicist evaluates season • Intramural corner • Cindermen seem strong as five lettermen return • Chief McClure hustles vagrant to county jail • Collegeville tops Phoenix YMCA basketball league • Collegeville firemen take part in Phila. exhibit • Faculty hoopsters triumph in benefit against girls • Graduate grantshttps://digitalcommons.ursinus.edu/weekly/1314/thumbnail.jp

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

Background: The trimeric envelope glycoproteins (Env) on the surface of HIV-1 virions are the targets for neutralizing antibodies (NAbs). No candidate HIV-1 immunogen has yet induced potent, broadly active NAbs (bNAbs). Part of the explanation may be that previously tested Env proteins inadequately mimic the functional, native Env complex. Trimerization and the proteolytic processing of Env precursors into gp120 and gp41 profoundly alter antigenicity, but soluble cleaved trimers are too unstable to serve as immunogens. By introducing stabilizing mutations (SOSIP), we constructed soluble, cleaved Env trimers derived from the HIV-1 subtype A isolate BG505 that resemble native Env spikes on virions both structurally and antigenically. Results: We used surface plasmon resonance (SPR) to quantify antibody binding to different forms of BG505 Env: the proteolytically cleaved SOSIP.664 trimers, cleaved gp120-gp41ECTO protomers, and gp120 monomers. Non-NAbs to the CD4-binding site bound only marginally to the trimers but equally well to gp120-gp41ECTO protomers and gp120 monomers, whereas the bNAb VRC01, directed to the CD4bs, bound to all three forms. In contrast, bNAbs to V1V2 glycan-dependent epitopes bound preferentially (PG9 and PG16) or exclusively (PGT145) to trimers. We also explored the antigenic consequences of three different features of SOSIP.664 gp140 trimers: the engineered inter-subunit disulfide bond, the trimer-stabilizing I559P change in gp41ECTO, and proteolytic cleavage at the gp120-gp41ECTO junction. Each of these three features incrementally promoted native-like trimer antigenicity. We compared Fab and IgG versions of bNAbs and validated a bivalent model of IgG binding. The NAbs showed widely divergent binding kinetics and degrees of binding to native-like BG505 SOSIP.664. High off-rate constants and low stoichiometric estimates of NAb binding were associated with large amounts of residual infectivity after NAb neutralization of the corresponding BG505.T332N pseudovirus. Conclusions: The antigenicity and structural integrity of cleaved BG505 SOSIP.664 trimers render these proteins good mimics of functional Env spikes on virions. In contrast, uncleaved gp140s antigenically resemble individual gp120-gp41ECTO protomers and gp120 monomers, but not native trimers. Although NAb binding to functional trimers may thus be both necessary and sufficient for neutralization, the kinetics and stoichiometry of the interaction influence the neutralizing efficacy of individual NAbs