Additional file 1: of Development and validation of the Crohn’s disease patient-reported outcomes signs and symptoms (CD-PRO/SS) diary

Development and validation of the Crohn’s Disease Patient-reported Outcomes Signs and Symptoms (CD-PRO/SS) Diary. (DOCX 117 kb

Age- and gender-stratified mean scores in the PROPr Estimation sample.

<p>HUI 2 is the Health Utilities Index Mark 2, HUI 3 is the Health Utilities Index Mark 3, EQ-5D US Mapped is the Euroqol-5D-5L mapped to the US valuation set, PROPr is the PROMIS-Preference score.</p

Age- and gender-stratified mean scores in the Profiles-HUI sample.

<p>HUI 2 is the Health Utilities Index Mark 2, HUI 3 is the Health Utilities Index Mark 3, PROPr is the PROMIS-Preference score.</p

Age- and gender-stratified health condition impacts in the Profiles-HUI sample.

<p>HUI 2 is the Health Utilities Index Mark 2, HUI 3 is the Health Utilities Index Mark 3, PROPr is the PROMIS-Preference score. All estimates are statistically significant.</p

Pearson correlations between summary scores in the PROPr Estimation survey.

<p>Pearson correlations between summary scores in the PROPr Estimation survey.</p

Distribution of summary scores in the PROPr Estimation sample.

<p>HUI 2 is the Health Utilities Index Mark 2, HUI 3 is the Health Utilities Index Mark 3, EQ-5D US Mapped is the Euroqol-5D-5L mapped to the US valuation set, PROPr is the PROMIS-Preference score.</p

Age- and gender-stratified health condition impacts in the PROPr Estimation sample.

<p>HUI 2 is the Health Utilities Index Mark 2, HUI 3 is the Health Utilities Index Mark 3, EQ-5D US Mapped is the Euroqol-5D-5L mapped to the US valuation set, PROPr is the PROMIS-Preference score. Statistically significant estimates are indicated with a star.</p

Distribution of summary scores in the Profiles-HUI sample.

<p>HUI 2 is the Health Utilities Index Mark 2, HUI 3 is the Health Utilities Index Mark 3, PROPr is the PROMIS-Preference score.</p

Demographic characteristics of the Dutch AMS-PAIN sample (n = 1085) and the US ACPA sample (n = 967).

<p>PROMIS Global Health Pain Intensity (0–10); NDI = Neck Disability Index (0–50); DASH = Disabilities of the Arm, Shoulder and Hand (0–100); RMDQ = Roland Morris Disability Questionnaire (0–24); FIQ = Fibromyalgia Impact Questionnaire (0–100). Higher scores indicate more intensity, disability or impact</p><p>* multiple answers were allowed</p><p>^ p<0.05</p><p>^^p<0.001.</p><p>Demographic characteristics of the Dutch AMS-PAIN sample (n = 1085) and the US ACPA sample (n = 967).</p

The overall impact of DIF for language on the test characteristic curves (TCC).

<p>The TCC shows the relation between the total item scores (y-axis) and theta (x-axis). Left graph shows the TCC for all 40 Dutch-Flemish (DF) and United States (US) PROMIS Pain Interference items (ignoring DIF); the right graph shows the TCC for just the 2 items having DIF.</p