1,469 research outputs found

    Vapor Extraction Well Performance and Recommendations for Transitioning to Passive Extraction at the Former DUS-II Site

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    This investigation evaluated mass extraction rate from individual wells associated with the Western Sector Treatment System (formerly known as the DUS-II project). This was critical since each individual well can have a radius of influence in excess of 100-ft when operating using an active extraction system. Future soil vapor extraction should use the existing active extraction system, supplemented with deployment of passive extraction where appropriate

    Three-dimensional reconstruction of autologous vein bypass graft distal anastomoses imaged with magnetic resonance: clinical and research applications

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    AbstractHigh-resolution magnetic resonance imaging was combined with computational modeling to create focused three-dimensional reconstructions of the distal anastomotic region of autologous vein peripheral bypass grafts in a preliminary series of patients. Readily viewed on a personal computer or printed as hard copies, a detailed appreciation of in vivo postoperative features of the anastomosis is possible. These reconstructions are suitable for analysis of geometric features, including vessel caliber, tortuosity, anastomotic angles, and planarity. Some potential clinical and research applications of this technique are discussed

    Three-dimensional reconstruction of autologous vein bypass graft distal anastomoses imaged with magnetic resonance: clinical and research applications

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    AbstractHigh-resolution magnetic resonance imaging was combined with computational modeling to create focused three-dimensional reconstructions of the distal anastomotic region of autologous vein peripheral bypass grafts in a preliminary series of patients. Readily viewed on a personal computer or printed as hard copies, a detailed appreciation of in vivo postoperative features of the anastomosis is possible. These reconstructions are suitable for analysis of geometric features, including vessel caliber, tortuosity, anastomotic angles, and planarity. Some potential clinical and research applications of this technique are discussed

    Characterization of Na+-permeable cation channels in LLC-PK1 renal epithelial cells

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    In this study, the presence of Na+-permeable cation channels was determined and characterized in LLC-PK1 cells, a renal tubular epithelial cell line with proximal tubule characteristics derived from pig kidney. Patch-clamp analysis under cell-attached conditions indicated the presence of spontaneously active Na+-permeable cation channels. The channels displayed nonrectifying single channel conductance of 11 pS, substates, and an ∌3:1 Na+/K+ permeability-selectivity ratio. The Na+-permeable cation channels were inhibited by pertussis toxin and reactivated by G protein agonists. Cation channel activity was observed in quiescent cell-attached patches after vasopressin stimulation. The addition of protein kinase A and ATP to excised patches also induced Na+ channel activity. Spontaneous and vasopressin-induced Na+ channel activity were inhibited by extracellular amiloride. To begin assessing potential molecular candidates for this cation channel, both reverse transcription-PCR and immunocytochemical analyses were conducted in LLC-PK1 cells. Expression of porcine orthologs of the αENaC and ApxL genes were found in LLC-PK1 cells. The expression of both gene products was confirmed by immunocytochemical analysis. Although αENaC labeling was mostly intracellular, ApxL labeled to both the apical membrane and cytoplasmic compartments of subconfluent LLC-PK1 cells. Vasopressin stimulation had no effect on αENaC immunolabeling but modified the cellular distribution of ApxL, consistent with an increased membrane-associated ApxL. The data indicate that proximal tubular LLC-PK1 renal epithelial cells express amiloride-sensitive, Na+-permeable cation channels, which are regulated by the cAMP pathway, and G proteins. This channel activity may implicate previously reported epithelial channel proteins, although this will require further experimentation. The evidence provides new clues as to potentially relevant Na+ transport mechanisms in the mammalian proximal nephron.Fil: Raychowdhury, Malay K.. Harvard Medical School; Estados Unidos. Massachusetts General Hospital East; Estados UnidosFil: Ibarra, Cristina Adriana. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂ­mica. Departamento de QuĂ­mica AnalĂ­tica y FisicoquĂ­mica. CĂĄtedra de QuĂ­mica General e InorgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas; ArgentinaFil: Damiano, Alicia Ermelinda. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂ­mica. Departamento de QuĂ­mica AnalĂ­tica y FisicoquĂ­mica. CĂĄtedra de QuĂ­mica General e InorgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas; ArgentinaFil: Jackson Jr., George R.. Massachusetts General Hospital East; Estados UnidosFil: Smith, Peter R.. University of Alabama at Birmingahm; Estados UnidosFil: McLaughlin, Margaret. Massachusetts General Hospital East; Estados UnidosFil: Prat, Adriana G.. Massachusetts General Hospital East; Estados Unidos. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Ausiello, Dennis A.. Harvard Medical School; Estados Unidos. Massachusetts General Hospital East; Estados UnidosFil: Lader, Alan S.. Harvard Medical School; Estados Unidos. Massachusetts General Hospital East; Estados UnidosFil: Cantiello, Horacio Fabio. Massachusetts General Hospital East; Estados Unidos. Harvard Medical School; Estados Unidos. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂ­mica. Departamento de QuĂ­mica AnalĂ­tica y FisicoquĂ­mica. CĂĄtedra de QuĂ­mica General e InorgĂĄnica; Argentina. Consejo Nacional de Investigaciones CientĂ­ficas y TĂ©cnicas; Argentin

    Protecting climate with forests

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    Policies for climate mitigation on land rarely acknowledge biophysical factors, such as reflectivity, evaporation, and surface roughness. Yet such factors can alter temperatures much more than carbon sequestration does, and often in a conflicting way. We outline a framework for examining biophysical factors in mitigation policies and provide some best-practice recommendations based on that framework. Tropical projects-avoided deforestation, forest restoration, and afforestation-provide the greatest climate value, because carbon storage and biophysics align to cool the Earth. In contrast, the climate benefits of carbon storage are often counteracted in boreal and other snow-covered regions, where darker trees trap more heat than snow does. Managers can increase the climate benefit of some forest projects by using more reflective and deciduous species and through urban forestry projects that reduce energy use. Ignoring biophysical interactions could result in millions of dollars being invested in some mitigation projects that provide little climate benefit or, worse, are counter-productive

    The Antarctic Submillimeter Telescope and Remote Observatory (AST/RO)

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    AST/RO, a 1.7 m diameter telescope for astronomy and aeronomy studies at wavelengths between 200 and 2000 microns, was installed at the South Pole during the 1994-1995 Austral summer. The telescope operates continuously through the Austral winter, and is being used primarily for spectroscopic studies of neutral atomic carbon and carbon monoxide in the interstellar medium of the Milky Way and the Magellanic Clouds. The South Pole environment is unique among observatory sites for unusually low wind speeds, low absolute humidity, and the consistent clarity of the submillimeter sky. Four heterodyne receivers, an array receiver, three acousto-optical spectrometers, and an array spectrometer are installed. A Fabry-Perot spectrometer using a bolometric array and a Terahertz receiver are in development. Telescope pointing, focus, and calibration methods as well as the unique working environment and logistical requirements of the South Pole are described.Comment: 57 pages, 15 figures. Submitted to PAS

    Building a circular supply chain:Achieving resilient operations with the circular economy

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    This paper highlights the fundamental contribution that supply chain professionals can make to the transition to a circular economy. It aims to provide a general understanding of how the circular economy and supply chain management fields are related to one another. By exploring the concept of a circular supply chain, the paper illustrates the role of supply chain professionals in operationalising circular economy initiatives within their organisations, as well as the opportunities and challenges they may encounter along the way. The paper also provides initialrecommendations for and examples of companies overcoming some of these challenges, based on the experiences of supply chain professionals involved in the research

    Land Use Change to Reduce Freshwater Nitrogen and Phosphorus will Be Effective Even with Projected Climate Change

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    Recent studies have demonstrated that projected climate change will likely enhance nitrogen (N) and phosphorus (P) loss from farms and farmland, with the potential to worsen freshwater eutrophication. Here, we investigate the relative importance of the climate and land use drivers of nutrient loss in nine study catchments in Europe and a neighboring country (Turkey), ranging in area from 50 to 12,000 km2. The aim was to quantify whether planned large-scale, land use change aimed at N and P loss reduction would be effective given projected climate change. To this end, catchment-scale biophysical models were applied within a common framework to quantify the integrated effects of projected changes in climate, land use (including wastewater inputs), N deposition, and water use on river and lake water quantity and quality for the mid-21st century. The proposed land use changes were derived from catchment stakeholder workshops, and the assessment quantified changes in mean annual N and P concentrations and loads. At most of the sites, the projected effects of climate change alone on nutrient concentrations and loads were small, whilst land use changes had a larger effect and were of sufficient magnitude that, overall, a move to more environmentally focused farming achieved a reduction in N and P concentrations and loads despite projected climate change. However, at BeyƟehir lake in Turkey, increased temperatures and lower precipitation reduced water flows considerably, making climate change, rather than more intensive nutrient usage, the greatest threat to the freshwater ecosystem. Individual site responses did however vary and were dependent on the balance of diffuse and point source inputs. Simulated lake chlorophyll-a changes were not generally proportional to changes in nutrient loading. Further work is required to accurately simulate the flow and water quality extremes and determine how reductions in freshwater N and P translate into an aquatic ecosystem response
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