A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-8

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p> of each trial. Note a trend over time towards no effect. No summary statistic is shown owing to excessive heterogeneity

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-4

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p>atment arm (-axis) of each study. Studies are weighted by inverse variance (i.e. larger symbols represent larger studies with less variability). Open circles denote cluster 2 studies [10, 11, 14, 25]. : Box plot of change in creatinine from baseline to study endpoint in the control arm and NAC treatment arm of each study. Boxes represent the 25th, 50th and 75th percentiles. Whiskers are 5th and 95th percentiles. Dashed lines show the mean of each group. Open squares denote cluster 2 studies

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-6

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p>ine studies. Axes are in logarithmic scale. The RR of CIN would have to be less than 0.67 in order for the RR of hemodialysis not to be on the side of harm (RR < 1)

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-1

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p> of each trial. Note a trend over time towards no effect. No summary statistic is shown owing to excessive heterogeneity

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-2

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p> identified as contributing most to heterogeneity are noted with open circles and are seen to produce asymmetry in the plot. The summary log RR for all 22 studies is denoted by the open diamond

A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity-3

<p><b>Copyright information:</b></p><p>Taken from "A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity"</p><p>http://www.biomedcentral.com/1741-7015/5/32</p><p>BMC Medicine 2007;5():32-32.</p><p>Published online 14 Nov 2007</p><p>PMCID:PMC2200657.</p><p></p>dies. Removing any of the 10 studies at the top of the plot decreases heterogeneity, while removing any of the 12 studies at the bottom of the plot increases heterogeneity. The four studies that individually contributed the most to heterogeneity are shown as open circles. Circle size is proportional to the inverse variance