Multivariate model evaluating the association between SPARC, SPARC7 and relapse free survival in all patients and according to breast cancer subtype.

*<p>on inserting SPARC7 instead of SPARC in the model.</p

Characteristics of the untreated cohort and correlation with SPARC expression.

*<p>5 patients had missing estrogen receptor status.</p

ORs for pCR for unit increase in module score after adjustment in a logistic regression model.

<p><b>A)</b> All patients (n = 791, pCR = 175); <b>B)</b> Patients with HER2 subtype (n = 86, pCR = 22); <b>C)</b> Patients with basal subtype (n = 316, pCR = 106); <b>D)</b> Patients with luminal-A subtype (n = 129, pCR = 6); <b>E)</b> Patients with luminal-B subtype (n = 260, pCR = 41). FDR, false discovery rate.</p

Association between SPARC expression and relapse free survival (RFS) in the systemically untreated cohort.

<p><b>A)</b> All patients (n = 754, low: 251, intermediate: 243, high: 260); <b>B)</b> Patients with HER2 subtype (n = 67, low: 24, intermediate: 20, high: 23); <b>C)</b> Patients with basal subtype (n = 132, low: 44, intermediate: 43, high: 45); <b>D)</b> Patients with luminal-A subtype (n = 265; low: 89; intermediate: 86; high: 90) and luminal-B subtype (n = 290, low: 97, intermediate: 94, high: 99).</p

Heat map showing correlation between SPARC, SPARC7 and different gene modules in the systemically untreated cohort (n = 948).

<p>Red indicates positive and green indicates negative correlation.</p

Patient and tumor characteristics: Breast tumor characteristics of study patients and their response to neoadjuvant chemotherapy evaluated by MRI and final pathology.

<p>Patient and tumor characteristics: Breast tumor characteristics of study patients and their response to neoadjuvant chemotherapy evaluated by MRI and final pathology.</p

Fluorescence intensity (Visual and quantitative scale) by mastectomy sample status and ICG-FI accuracy.

<p>Fluorescence intensity (Visual and quantitative scale) by mastectomy sample status and ICG-FI accuracy.</p

Pathological and fluorescence imaging characteristics of mastectomy samples: Characteristics of mastectomy samples evaluated by indocyanine green-fluorescence imaging after standard pathological evaluation of the 9 breast tumor surgical specimens.

<p>Pathological and fluorescence imaging characteristics of mastectomy samples: Characteristics of mastectomy samples evaluated by indocyanine green-fluorescence imaging after standard pathological evaluation of the 9 breast tumor surgical specimens.</p

Combined CD10 and VPNI risk.

<p>(A) Cross-tabulation between CD10 qRT-PCR expression and VNPI score. (B) Disease-free survival analysis for patients with DCIS according to CD10 mRNA expression by qRT-PCR combined with VNPI risk group.</p

CD10 immunostaining of the myoepithelial cell (MECs) layer (original magnification <b>×</b>200).

<p>(A) intense staining (3) and a circumferential membrane expression (3) observed on normal breast (score = 6); (B) intense staining (3) and a circumferential membrane expression (3) observed on DCIS (score = 6); (C) intermediate staining (2) and partial membrane expression (2) observed on DCIS (score = 4); (D) weak staining (1) and focal membrane expression (1) observed on DCIS (score = 2).</p