Relation between surface solitons and bulk solitons in nonlocal nonlinear media

We find that a surface soliton in nonlocal nonlinear media can be regarded as a half of a bulk soliton with an antisymmetric amplitude distribution. The analytical solutions for the surface solitons and breathers in strongly nonlocal media are obtained, and the critical power and breather period are gotten analytically and confirmed by numerical simulations. In addition, the oscillating propagation of nonlocal surface solitons launched away from the stationary position is considered as the interaction between the soliton and its out-of-phase image beam. Its trajectory and oscillating period obtained by our model are in good agreement with the numerical simulations.Comment: 12 pages, 8 figures, 39 reference, Accepted by Opt. Expres

Topical Application of an Irreversible Small Molecule Inhibitor of Lysyl Oxidases Ameliorates Skin Scarring and Fibrosis

Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a family of enzymes that play a critical role in scar formation and maintenance. Lysyl oxidases stabilize the main component of scar tissue, collagen, and drive scar stiffness and appearance. Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302. PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity. In murine models of injury and fibrosis, topical application reduces collagen deposition and cross-linking. Topical application of PXS-6302 after injury also significantly improves scar appearance without reducing tissue strength in porcine injury models. PXS-6302 therefore represents a promising therapeutic to ameliorate scar formation, with potentially broader applications in other fibrotic diseases

Thermal comfort evaluation of a mixed-mode ventilated office building with advanced natural ventilation and underfloor air distribution systems

This study uses field monitoring and post occupancy evaluation (POE) surveys to investigate the indoor thermal comfort of an office building that is located in subtropical zone. The building is special as it combines advanced natural ventilation (ANV) strategies and underfloor air distribution (UFAD) systems. A comparison between a static thermal comfort model and a dynamic thermal comfort model is also conducted. The results show that the thermal comfort conditions in the case study building are satisfactory in summer while in winter there is evidence of thermal discomfort. For the case study building, the static thermal comfort model gives outputs that matched well with the responses of the occupants during the POE survey in winter while the dynamic model is more representative of the sensation of the occupants in summer

Numerical analysis of indoor thermal comfort in a cross-ventilated space with top-hung windows

Natural ventilation can be used in residential buildings in several Australian climatic zones and well-designed windows have the potential to facilitate indoor thermal comfort by allowing occupants to control volumetric outdoor airflow and indoor air velocities. Top-hung window is one of the most popular window types in Australia. This paper investigates the effect of the attributes of top-hung windows (i.e. window length, aspect ratio, height above the ground, window opening angle and the fly screen porosity) and outdoor air conditions (i.e. outdoor air temperature, wind speed and direction) on indoor thermal comfort during cross ventilation using CFD simulations. The Taguchi method was used to design the simulation scenarios and analysis of variance was used to determine the most significant factors influencing thermal comfort optimisation so as to reduce the number of CFD simulation cases. For the range of parameters considered and a particular case study building, results show that outdoor air temperature, window height and window opening angle are the most important factors influencing indoor thermal comfort in this room. The optimal window configurations for indoor thermal comfort of the case study building are also identified using a signal-to-noise ratio analysis

Failure Mechanism of Rock Slopes under Different Seismic Excitation

In earthquake-prone areas, special attention should be paid to the study of the seismic stability of rock slope. Particularly, it becomes much more complicated for the rock slopes with weak structural surfaces. In this study, numerical simulation and the shaking table test are carried out to analyze the influence of seismic excitation and structural surface in different directions on dynamic response of rock slope. Huaping slope with bedding structural surfaces and Lijiang slope with discontinuous structural surfaces besides Jinsha River in Yunnan Province are taken as research objects. The results of numerical simulation and the model test both show that discontinuous structure surface has influence on the propagation characteristics of seismic wavefield. For Huaping slope, the seismic wavefield responses repeatedly between the bedding structural surface and slope surface lead to the increase of the amplification effect. The maximum value of seismic acceleration appears on the empty surface where terrain changes. Horizontal motion plays a leading role in slope failure, and the amplification coefficient of horizontal seismic acceleration is about twice that of vertical seismic acceleration. The failure mode is integral sliding along the bedding structural surface. For Lijiang slope, seismic acceleration field affected by complex structural surface is superimposed repeatedly in local area. The maximum value of seismic acceleration appears in the local area near slope surface. And the dynamic response of slope is controlled by vertical and horizontal motion together. Under the seismic excitation with an intense of 0.336 g in X direction and Z direction, the amplification coefficients of seismic acceleration of Lijiang slope are 3.23 and 3.18, respectively. The vertical motion leads to the cracking of the weak structural surface. Then, Lijiang slope shows the toppling failure mode under the action of horizontal motion

Research on heat transfer of the closed-loop thermosyphon system with microencapsulated phase change material suspension

© 2019 International Institute of Refrigeration. All rights reserved. Heat generation of datacenters becomes larger and larger because of the improvement of operational performance of equipment and the expansion of datacenter scale. Two-phase closed-loop thermosyphon system as a new type of cooling system, which has a large cooling capacity, has gotten a widespread attention. This paper investigates experimentally heat transfer performance of a closed-loop thermosyphon system by testing under different mass concentrations, heating and cooling scenarios. The system, filled with microencapsulated phase change material suspension (MPCMS), contains heating, cooling and adiabatic sections. The result shows that the convective heat transfer coefficient at the heating section inlet with 0.5% MPCMS is twice as much as that of base fluid. Hence, a closed-loop thermosyphon system with MPCMS is an effective scheme to enhance the performance of the cooling system

Application of sialic acid/polysialic acid in the drug delivery systems

AbstractThe properties of modified biomaterial are gaining more and more importance in drug delivery systems. Sialic acid (SA) and polysialic acid (PSA) serve as endogenous substances, which are non-immunogenic and biodegradable. At the same time, SA modification of the drugs/carriers can enhance the uptake of tumor cell and retention in brain; PSA modification can reduce the immunogenicity of the proteins or polypeptides and increase circulation time of the modified drugs/carriers in the blood, thus achieving active targeting effect. These properties offer a variety of opportunities for applications in drug delivery systems. This article summarizes the biological functions of SA and PSA and presents the technologies of SA/PSA modified small molecule drugs, proteins and carriers in drug delivery systems