Expression and prognostic significance of cancer-testis antigens (CTA) in intrahepatic cholagiocarcinoma

<p>Abstract</p> <p>Background</p> <p>Cancer-testis antigens (CTAs) are suitable targets for cancer-specific immunotherapy. The aim of the study is to investigate the expression of CTAs in intrahepatic cholagiocarcinoma (IHCC) and evaluate their potential therapeutic values.</p> <p>Methods</p> <p>Eighty-nine IHCC patients were retrospectively assessed for their expression of CTAs and HLA Class I by immunohistochemistry using the following antibodies: MA454 recognizing MAGE-A1, 57B recognizing multiple MAGE-A (MAGE-A3/A4), E978 recognizing NY-ESO-1, and EMR8-5 recognizing HLA class I. The clinicopathological and prognostic significance of individual CTA markers and their combination were further evaluated.</p> <p>Results</p> <p>The expression rates of MAGE-A1, MAGE-A3/4 and NY-ESO-1 were 29.2%, 27.0% and 22.5%, respectively. The concomitant expression of CTAs and HLA class I antigen was observed in 33.7% of the IHCC tumors. We found that positive MAGE-3/4 expression correlated with larger tumor size (≥ 5 cm), tumor recurrence and poor prognosis. Moreover, we identified 52 cases (58.4%) of IHCC patients with at least one CTA marker expression, and this subgroup displayed a higher frequency of larger tumor size and a shorter survival than the other cases. Furthermore, expression of at least one CTA marker was also an independent prognostic factor in patients with IHCC.</p> <p>Conclusion</p> <p>Our data suggest that specific immunotherapy targeted CTAs might be a novel treatment option for IHCC patients.</p

A Modified Scalar-Tensor-Vector Gravity Theory and the Constraint on its Parameters

A gravity theory called scalar-tensor-vector gravity (STVG) has been recently developed and succeeded in solar system, astrophysical and cosmological scales without dark matter [J. W. Moffat, J. Cosmol. Astropart. Phys. 03, 004 (2006)]. However, two assumptions have been used: (i) $B(r)=A^{-1}(r)$, where $B(r)$ and $A(r)$ are $g_{00}$ and $g_{rr}$ in the Schwarzschild coordinates (static and spherically symmetric); (ii) scalar field $G=Const.$ in the solar system. These two assumptions actually imply that the standard parametrized post-Newtonian parameter $\gamma=1$. In this paper, we relax these two assumptions and study STVG further by using the post-Newtonian (PN) approximation approach. With abandoning the assumptions, we find $\gamma\neq1$ in general cases of STVG. Then, a version of modified STVG (MSTVG) is proposed through introducing a coupling function of scalar field G: $\theta(G)$. We have derived the metric and equations of motion (EOM) in 1PN for general matter without specific equation of state and $N$ point masses firstly. Subsequently, the secular periastron precession $\dot{\omega}$ of binary pulsars in harmonic coordinates is given. After discussing two PPN parameters ($\gamma$ and $\beta$) and two Yukawa parameters ($\alpha$ and $\lambda$), we use $\dot{\omega}$ of four binary pulsars data (PSR B1913+16, PSR B1534+12, PSR J0737-3039 and PSR B2127+11C) to constrain the Yukawa parameters for MSTVG: $\lambda=(3.97\pm0.01)\times10^{8}$m and $\alpha=(2.40\pm0.02)\times10^{-8}$ if we fix $|2\gamma-\beta-1|=0$.Comment: 39 pages, 4 figures, accepted by PR

The association between post-stroke depression, aphasia, and physical independence in stroke patients at 3-month follow-up

Objective: Few studies have examined the association between post-stroke depression (PSD), aphasia, and physical independence in Chinese patients. This study investigated the above association in stroke patients in China at 3-month follow-up. Methods: Altogether 270 patients within 14 days after ischemic stroke were recruited and followed up at 3 months. PSD, aphasia, and physical functional status were measured using the Stroke Aphasia Depression Questionnaire (SADQ), Western Aphasia Battery (WAB), and modified Rankin Scale (mRS), respectively. Patients with mRS total score \u3e2 were considered as having “physical dependence.” Results: Out of 248 patients at 3-month follow up, 119 (48%) were rated as having physical dependence. Multiple logistic regression analyses revealed that female (p = 0.04; OR = 2.2; 95% CI: 1.0–5.1), more severe stroke at admission (p \u3c 0.01; OR = 1.4; 95% CI: 1.3–1.5), and more severe PSD at 3 months (p = 0.01; OR = 1.05; 95% CI: 1.01–1.1) were independently associated with physical dependence at 3 months. Conclusions: Greater PSD and stroke severity were independently associated with physical dependence at 3months after stroke. Aphasia was also associated with physical dependence but the relationship was not significant. Early and effective depression screening, treatment and stroke rehabilitation appear to be important to improve the physical outcome and reduce the burden of stroke survivors