Correction: Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios.

An important detail was omitted in the Method of the original Article, I.E, The CARS and other evaluations were conducted 'blind' to condition (Bumetanide or no treatment) by experienced clinicians. This has now been updated in the HTML and PDF versions of this Article

Correction: Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios

An important detail was omitted in the Method of the original Article, I.E, The CARS and other evaluations were conducted ‘blind' to condition (Bumetanide or no treatment) by experienced clinicians. This has now been updated in the HTML and PDF versions of this Article

Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios

Funder: Shanghai Municipal Commission of Health and Family Planning Shanghai Shenkang Hospital Development Center Shanghai Municipal Education Commission National Natural Science Foundation of China Shanghai Committee of Science and Technology Xinhua Hospital of Shanghai Jiao Tong University School of Medicine Guangdong Key Project in "Development of new tools for diagnosis and treatment of Autism "Funder: Shanghai Municipal Commission of Health and Family Planning Shanghai Municipal Education Commission National Natural Science Foundation of China the National Key Research and Development Program of China ZJ LabFunder: National Human Genetic Resources Sharing Service Platform 111 Project ZJ LabFunder: National Natural Science Foundation of China ZJ LabAbstract: Bumetanide has been reported to alter synaptic excitation–inhibition (E-I) balance by potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating the severity of autism spectrum disorder (ASD) in animal models. However, clinical evidence of its efficacy in young patients with ASD is limited. This was investigated in the present clinical trial of 83 patients, randomised to the bumetanide group (bumetanide treatment, 0.5 mg twice daily) or the control group (no bumetanide treatment). Primary [Children Autism Rating Scale (CARS)], secondary [Clinical Global Impressions (CGI)], and exploratory [inhibitory (γ-aminobutyric acid, GABA) and excitatory (glutamate, Glx) neurotransmitter concentrations measured in the insular cortex (IC) and visual cortex (VC) by magnetic resonance spectroscopy (MRS)] outcome measures were evaluated at baseline and at the 3-month follow-up. Side effects were monitored throughout the treatment course. Compared with the control group, the bumetanide group showed significant reduction in symptom severity, as indicated by both total CARS score and number of items assigned a score ≥ 3. The improvement in clinical symptoms was confirmed by CGI. GABA/Glx ratio in both the IC and VC decreased more rapidly over the 3-month period in the bumetanide group than that in the control group. This decrease in the IC was associated with the symptom improvement in the bumetanide group. Our study confirmed the clinical efficacy of bumetanide on alleviating the core symptoms of ASD in young children and it is the first demonstration that the improvement is associated with reduction in GABA/Glx ratios. This study suggests that the GABA/Glx ratio measured by MRS may provide a neuroimaging biomarker for assessing treatment efficacy for bumetanide

Synthesis of supramolecular architectures using Pn-ligands as building blocks

In this thesis, chemical properties and coordination behaviors of different Pn-ligand complexes were studied and following aspects are engaged: i) The lone pairs of electrons on the phosphorus atoms in the Pn-ligands give a ligation propensity to transition metal centers, which lead to oligomers or polymers; ii) The ligation mode of P5-nCn-ring (n = 0-2) ligands toward the transition metal centers can be side-on or end-on; iii) The P5-nCn-ring (n = 0-2) of polyphosphaferrocenes during their reactions with transition metal salts can remain intact or fragmentise; iv) Replacement of CR fragments by phosphorus atoms in the P5-nCn-ring (n = 0-2) and different substituent groups on the cyclopentadiene ring additionally coordinated to the iron atom can influence the results of the coordination; and v) different copper halide clusters can be formed in these coordination reactions

Tetraphosphacyclopentadienyl and Triphosphaallyl Ligands in Iron Complexes [Tetraphosphacyclopentadienyl- und Triphosphaallyl-Liganden in Eisenkomplexen]

Different faces of phosphorus chemistry: The reaction of the bicyclotetraphosphine complex 1 with tBuCP leads to the first 1,2,3,4-tetraphosphaferrocene complex 2 and an allylic P3-bridged complex 3. Cp=5-C5H2tBu3

Efficient Binary Weight Convolutional Network Accelerator for Speech Recognition

Speech recognition has progressed tremendously in the area of artificial intelligence (AI). However, the performance of the real-time offline Chinese speech recognition neural network accelerator for edge AI needs to be improved. This paper proposes a configurable convolutional neural network accelerator based on a lightweight speech recognition model, which can dramatically reduce hardware resource consumption while guaranteeing an acceptable error rate. For convolutional layers, the weights are binarized to reduce the number of model parameters and improve computational and storage efficiency. A multichannel shared computation (MCSC) architecture is proposed to maximize the reuse of weight and feature map data. The binary weight-sharing processing engine (PE) is designed to avoid limiting the number of multipliers. A custom instruction set is established according to the variable length of voice input to configure parameters for adapting to different network structures. Finally, the ping-pong storage method is used when the feature map is an input. We implemented this accelerator on Xilinx ZYNQ XC7Z035 under the working frequency of 150 MHz. The processing time for 2.24 s and 8 s of speech was 69.8 ms and 189.51 ms, respectively, and the convolution performance reached 35.66 GOPS/W. Compared with other computing platforms, accelerators perform better in terms of energy efficiency, power consumption and hardware resource consumption

Maternal obesity caused by overnutrition exposure leads to reversal learning deficits and striatal disturbance in rats.

Maternal obesity caused by overnutrition during pregnancy increases susceptibility to metabolic risks in adulthood, such as obesity, insulin resistance, and type 2 diabetes; however, whether and how it affects the cognitive system associated with the brain remains elusive. Here, we report that pregnant obesity induced by exposure to excessive high fatty or highly palatable food specifically impaired reversal learning, a kind of adaptive behavior, while leaving serum metabolic metrics intact in the offspring of rats, suggesting a much earlier functional and structural defects possibly occurred in the central nervous system than in the metabolic system in the offspring born in unfavorable intrauterine nutritional environment. Mechanically, we found that above mentioned cognitive inflexibility might be associated with significant striatal disturbance including impaired dopamine homeostasis and disrupted leptin signaling in the adult offspring. These collective data add a novel perspective of understanding the adverse postnatal sequelae in central nervous system induced by developmental programming and the related molecular mechanism through which priming of risk for developmental disorders may occur during early life

Coordination Behavior of the 1,2,3-Triphosphaferrocene [Cp′′′Fe(η5-P3C2(H)Ph)] with Organometallic Moieties

The reaction of the 1,2,3-triphosphaferrocene [Cp′′′Fe(η5-P3C2(H)Ph)] (1) with the Lewis acidic complex [PtCl2(PEt3)]2 yields the monosubstituted derivative [Cp′′′Fe(η5-P3C2(H)Ph){PtCl2(PEt3)}] (2), in which the Pt moiety is located at the P atom adjacent to the C(H) group of the cyclo-P3C2 ring. Using an excess of the Pt complex no multiple substitution occurs. In contrast, using [W(CO)5] units as Lewis acids results in mono-, di-, and tricoordination at the cyclo-P3C2 ring. The products, [Cp′′′Fe(η5-P3C2(H)Ph){W(CO)5}n] (n = 1 (3), 2 (4), 3 (5)), have all been spectroscopically characterized, and the substitution patterns of the experimentally found (mono- and disubstituted) isomers are found to be in accordance with the energetically favored derivatives calculated by DFT methods. For these structures the energetically favored rotational conformers have also been calculated. The energetically favored 2,3-coordinated isomer 4b could be crystallized, and its structure and that of the tricoordinated derivative 5 were determined by X-ray diffraction methods

Synthesis and unprecedented coordination behaviour of a novel 1,2,3-triphosphaferrocene complex

A novel 1,2,3-triphosphaferrocene has been synthesised, which reacts with CuBr to give a 2D polymer, revealing an unprecedented -stacking of the triphospholyl moieties